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Prediction of Neonatal Respiratory Morbidity Assessed by Quantitative Ultrasound Lung Texture Analysis in Twin Pregnancies

Moreno-Espinosa, Ana L. LU ; Hawkins-Villarreal, Ameth ; Coronado-Gutierrez, David ; Burgos-Artizzu, Xavier P. ; Martínez-Portilla, Raigam J. ; Peña-Ramirez, Tatiana ; Gallo, Dahiana M. ; Hansson, Stefan R. LU orcid ; Gratacòs, Eduard and Palacio, Montse (2022) In Journal of Clinical Medicine 11(16).
Abstract

The objective of this study was to evaluate the performance of quantitative ultrasound of fetal lung texture analysis in predicting neonatal respiratory morbidity (NRM) in twin pregnancies. This was an ambispective study involving consecutive cases. Eligible cases included twin pregnancies between 27.0 and 38.6 weeks of gestation, for which an ultrasound image of the fetal thorax was obtained within 48 h of delivery. Images were analyzed using quantusFLM® version 3.0. The primary outcome of this study was neonatal respiratory morbidity, defined as the occurrence of either transient tachypnea of the newborn or respiratory distress syndrome. The performance of quantusFLM® in predicting NRM was analyzed by matching... (More)

The objective of this study was to evaluate the performance of quantitative ultrasound of fetal lung texture analysis in predicting neonatal respiratory morbidity (NRM) in twin pregnancies. This was an ambispective study involving consecutive cases. Eligible cases included twin pregnancies between 27.0 and 38.6 weeks of gestation, for which an ultrasound image of the fetal thorax was obtained within 48 h of delivery. Images were analyzed using quantusFLM® version 3.0. The primary outcome of this study was neonatal respiratory morbidity, defined as the occurrence of either transient tachypnea of the newborn or respiratory distress syndrome. The performance of quantusFLM® in predicting NRM was analyzed by matching quantitative ultrasound analysis and clinical outcomes. This study included 166 images. Neonatal respiratory morbidity occurred in 12.7% of cases, and it was predicted by quantusFLM® analysis with an overall sensitivity of 42.9%, specificity of 95.9%, positive predictive value of 60%, and negative predictive value of 92.1%. The accuracy was 89.2%, with a positive likelihood ratio of 10.4, and a negative likelihood ratio of 0.6. The results of this study demonstrate the good prediction capability of NRM in twin pregnancies using a non-invasive lung texture analysis software. The test showed an overall good performance with high specificity, negative predictive value, and accuracy.

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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
fetal lung maturity, neonatal respiratory morbidity, quantitative lung texture analysis, twin pregnancies
in
Journal of Clinical Medicine
volume
11
issue
16
article number
4895
publisher
MDPI AG
external identifiers
  • pmid:36013134
  • scopus:85137365986
ISSN
2077-0383
DOI
10.3390/jcm11164895
language
English
LU publication?
yes
id
237ec933-cf27-46bd-abce-6295d41016de
date added to LUP
2022-11-29 15:32:47
date last changed
2025-02-17 23:56:31
@article{237ec933-cf27-46bd-abce-6295d41016de,
  abstract     = {{<p>The objective of this study was to evaluate the performance of quantitative ultrasound of fetal lung texture analysis in predicting neonatal respiratory morbidity (NRM) in twin pregnancies. This was an ambispective study involving consecutive cases. Eligible cases included twin pregnancies between 27.0 and 38.6 weeks of gestation, for which an ultrasound image of the fetal thorax was obtained within 48 h of delivery. Images were analyzed using quantusFLM<sup>®</sup> version 3.0. The primary outcome of this study was neonatal respiratory morbidity, defined as the occurrence of either transient tachypnea of the newborn or respiratory distress syndrome. The performance of quantusFLM<sup>®</sup> in predicting NRM was analyzed by matching quantitative ultrasound analysis and clinical outcomes. This study included 166 images. Neonatal respiratory morbidity occurred in 12.7% of cases, and it was predicted by quantusFLM<sup>®</sup> analysis with an overall sensitivity of 42.9%, specificity of 95.9%, positive predictive value of 60%, and negative predictive value of 92.1%. The accuracy was 89.2%, with a positive likelihood ratio of 10.4, and a negative likelihood ratio of 0.6. The results of this study demonstrate the good prediction capability of NRM in twin pregnancies using a non-invasive lung texture analysis software. The test showed an overall good performance with high specificity, negative predictive value, and accuracy.</p>}},
  author       = {{Moreno-Espinosa, Ana L. and Hawkins-Villarreal, Ameth and Coronado-Gutierrez, David and Burgos-Artizzu, Xavier P. and Martínez-Portilla, Raigam J. and Peña-Ramirez, Tatiana and Gallo, Dahiana M. and Hansson, Stefan R. and Gratacòs, Eduard and Palacio, Montse}},
  issn         = {{2077-0383}},
  keywords     = {{fetal lung maturity; neonatal respiratory morbidity; quantitative lung texture analysis; twin pregnancies}},
  language     = {{eng}},
  number       = {{16}},
  publisher    = {{MDPI AG}},
  series       = {{Journal of Clinical Medicine}},
  title        = {{Prediction of Neonatal Respiratory Morbidity Assessed by Quantitative Ultrasound Lung Texture Analysis in Twin Pregnancies}},
  url          = {{http://dx.doi.org/10.3390/jcm11164895}},
  doi          = {{10.3390/jcm11164895}},
  volume       = {{11}},
  year         = {{2022}},
}