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The effects of enteral ghrelin administration on the remodeling of the small intestinal mucosa in neonatal piglets

Slupecka, Monika; Wolinski, Jaroslaw and Pierzynowski, Stefan LU (2012) In Regulatory Peptides 174(1-3). p.38-45
Abstract
Ghrelin is a multifunctional peptide produced predominantly in the stomach, however substantial amounts have also been found in colostrum and milk. The aim of the study was to investigate the effect of exogenous ghrelin, administered intra-gastrically, on the processes of mitosis, apoptosis, autophagy, crypt fission and changes in histometry of the small intestine mucosa in neonatal pigs, fed with a milk formula. Three groups (n = 6) of piglets were used in the study. The pigs were fed either milk formula (C7) or milk formula together with ghrelin, administered via a stomach tube (7.5 mu g/kg body weight (BW), (LG)) and 15 mu g/kg BW (HG), every 8 h for 6 days. Compared to the control group (C7), feeding milk formula supplemented with... (More)
Ghrelin is a multifunctional peptide produced predominantly in the stomach, however substantial amounts have also been found in colostrum and milk. The aim of the study was to investigate the effect of exogenous ghrelin, administered intra-gastrically, on the processes of mitosis, apoptosis, autophagy, crypt fission and changes in histometry of the small intestine mucosa in neonatal pigs, fed with a milk formula. Three groups (n = 6) of piglets were used in the study. The pigs were fed either milk formula (C7) or milk formula together with ghrelin, administered via a stomach tube (7.5 mu g/kg body weight (BW), (LG)) and 15 mu g/kg BW (HG), every 8 h for 6 days. Compared to the control group (C7), feeding milk formula supplemented with ghrelin resulted in significant changes in the small intestinal morphometry and mucosa histometry. The observed changes were dependent on the dosage of hormone and the part of intestine investigated. Administration of ghrelin via the stomach tube (HG) significantly influenced epithelial cell renewal. Moreover, we demonstrated that autophagy is involved in the small intestine mucosa remodeling and ghrelin may be an important factor for its regulation. In conclusion, we found that enteral ghrelin influences the gut mucosa remodeling in a dose-related manner in the early postnatal period. Moreover in neonates, stomach activity does not interfere with the action of ghrelin in the small intestine. (C) 2011 Elsevier B.V. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Piglets, Crypt fission, Autophagy, Cell turnover, Development
in
Regulatory Peptides
volume
174
issue
1-3
pages
38 - 45
publisher
Elsevier
external identifiers
  • wos:000301015900007
  • scopus:84856435164
ISSN
1873-1686
DOI
10.1016/j.regpep.2011.11.007
language
English
LU publication?
yes
id
64ac6b9f-7314-4944-a372-901559d06428 (old id 2384360)
date added to LUP
2012-03-27 14:21:25
date last changed
2017-08-20 03:16:50
@article{64ac6b9f-7314-4944-a372-901559d06428,
  abstract     = {Ghrelin is a multifunctional peptide produced predominantly in the stomach, however substantial amounts have also been found in colostrum and milk. The aim of the study was to investigate the effect of exogenous ghrelin, administered intra-gastrically, on the processes of mitosis, apoptosis, autophagy, crypt fission and changes in histometry of the small intestine mucosa in neonatal pigs, fed with a milk formula. Three groups (n = 6) of piglets were used in the study. The pigs were fed either milk formula (C7) or milk formula together with ghrelin, administered via a stomach tube (7.5 mu g/kg body weight (BW), (LG)) and 15 mu g/kg BW (HG), every 8 h for 6 days. Compared to the control group (C7), feeding milk formula supplemented with ghrelin resulted in significant changes in the small intestinal morphometry and mucosa histometry. The observed changes were dependent on the dosage of hormone and the part of intestine investigated. Administration of ghrelin via the stomach tube (HG) significantly influenced epithelial cell renewal. Moreover, we demonstrated that autophagy is involved in the small intestine mucosa remodeling and ghrelin may be an important factor for its regulation. In conclusion, we found that enteral ghrelin influences the gut mucosa remodeling in a dose-related manner in the early postnatal period. Moreover in neonates, stomach activity does not interfere with the action of ghrelin in the small intestine. (C) 2011 Elsevier B.V. All rights reserved.},
  author       = {Slupecka, Monika and Wolinski, Jaroslaw and Pierzynowski, Stefan},
  issn         = {1873-1686},
  keyword      = {Piglets,Crypt fission,Autophagy,Cell turnover,Development},
  language     = {eng},
  number       = {1-3},
  pages        = {38--45},
  publisher    = {Elsevier},
  series       = {Regulatory Peptides},
  title        = {The effects of enteral ghrelin administration on the remodeling of the small intestinal mucosa in neonatal piglets},
  url          = {http://dx.doi.org/10.1016/j.regpep.2011.11.007},
  volume       = {174},
  year         = {2012},
}