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Troponin T levels associated with genetic variants in NOTCH2 and MTNR1B in women with psychosis

Hukic, Dzana Sudic ; Lavebratt, Catharina ; Olsson, Eric ; Östenson, Claes-Göran ; Eriksson, Sven V. ; Erlinge, David LU orcid ; Schalling, Martin and Ösby, Urban (2017) In Psychiatry Research 250. p.217-220
Abstract

Psychosis patients have increased prevalence of metabolic disorders, which increase the risk for cardiovascular disease. Elevated troponin T level is an early biomarker of cardiovascular damage. We tested for association between troponin T levels and genetic risk variants of elevated blood glucose level in psychosis. Glucose and troponin T levels correlated positively. MTNR1B rs10830963 and NOTCH2 rs10923931 associated with troponin T levels in women, adjusted for glucose levels. These findings may indicate metabolic genetic influences on troponin T levels among women with psychosis.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cardiovascular biomarker, Schizophrenia, Type 2 diabetes
in
Psychiatry Research
volume
250
pages
4 pages
publisher
Elsevier
external identifiers
  • scopus:85012305721
  • pmid:28167435
  • wos:000397685200033
ISSN
0165-1781
DOI
10.1016/j.psychres.2017.01.030
language
English
LU publication?
yes
id
23ae7a89-a0a1-46a0-bdf3-c650e6ad428a
date added to LUP
2017-02-27 08:39:06
date last changed
2025-10-14 19:52:37
@article{23ae7a89-a0a1-46a0-bdf3-c650e6ad428a,
  abstract     = {{<p>Psychosis patients have increased prevalence of metabolic disorders, which increase the risk for cardiovascular disease. Elevated troponin T level is an early biomarker of cardiovascular damage. We tested for association between troponin T levels and genetic risk variants of elevated blood glucose level in psychosis. Glucose and troponin T levels correlated positively. MTNR1B rs10830963 and NOTCH2 rs10923931 associated with troponin T levels in women, adjusted for glucose levels. These findings may indicate metabolic genetic influences on troponin T levels among women with psychosis.</p>}},
  author       = {{Hukic, Dzana Sudic and Lavebratt, Catharina and Olsson, Eric and Östenson, Claes-Göran and Eriksson, Sven V. and Erlinge, David and Schalling, Martin and Ösby, Urban}},
  issn         = {{0165-1781}},
  keywords     = {{Cardiovascular biomarker; Schizophrenia; Type 2 diabetes}},
  language     = {{eng}},
  month        = {{04}},
  pages        = {{217--220}},
  publisher    = {{Elsevier}},
  series       = {{Psychiatry Research}},
  title        = {{Troponin T levels associated with genetic variants in NOTCH2 and MTNR1B in women with psychosis}},
  url          = {{http://dx.doi.org/10.1016/j.psychres.2017.01.030}},
  doi          = {{10.1016/j.psychres.2017.01.030}},
  volume       = {{250}},
  year         = {{2017}},
}