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Extrapancreatic contribution to glucose regulation by dipeptidyl peptidase 4 inhibition

Omar, Bilal A. LU and Ahrén, Bo LU (2016) In Cardiovascular Endocrinology 5(3). p.82-85
Abstract

Dipeptidyl peptidase 4 (DPP-4) inhibitors are now being clinically utilized as glucose-lowering medications for the treatment of type 2 diabetes. Their widespread use and effective glucose-lowering properties have led to great interest in the mechanism of action of this class of drug. Although it has been well accepted that DPP-4 inhibitors lower glucose in part by increasing postprandial insulin secretion and suppressing fasting and postprandial hyperglucagonemia, recent studies have suggested that DPP-4 inhibition has other metabolically beneficial properties that are extrapancreatic in nature. This review explores the changes in DPP-4 expression and activity in metabolic disease states and discusses the metabolic consequences of... (More)

Dipeptidyl peptidase 4 (DPP-4) inhibitors are now being clinically utilized as glucose-lowering medications for the treatment of type 2 diabetes. Their widespread use and effective glucose-lowering properties have led to great interest in the mechanism of action of this class of drug. Although it has been well accepted that DPP-4 inhibitors lower glucose in part by increasing postprandial insulin secretion and suppressing fasting and postprandial hyperglucagonemia, recent studies have suggested that DPP-4 inhibition has other metabolically beneficial properties that are extrapancreatic in nature. This review explores the changes in DPP-4 expression and activity in metabolic disease states and discusses the metabolic consequences of DPP-4 inhibition on a systemic and tissue-specific basis. It concludes that there is considerable scientific evidence and a growing body of clinical evidence to suggest that DPP-4 inhibition would be beneficial in a number of metabolic disorders in addition to type 2 diabetes.

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Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
dipeptidyl peptidase-4, glucose, insulin, insulin sensitivity, liver
in
Cardiovascular Endocrinology
volume
5
issue
3
pages
4 pages
publisher
Lippincott Williams and Wilkins
external identifiers
  • scopus:85000502014
  • wos:000389477700005
DOI
10.1097/XCE.0000000000000088
language
English
LU publication?
yes
id
23ca0134-39dc-401d-b41b-aa7cf134c25f
date added to LUP
2016-12-30 13:43:01
date last changed
2017-09-18 11:35:02
@article{23ca0134-39dc-401d-b41b-aa7cf134c25f,
  abstract     = {<p>Dipeptidyl peptidase 4 (DPP-4) inhibitors are now being clinically utilized as glucose-lowering medications for the treatment of type 2 diabetes. Their widespread use and effective glucose-lowering properties have led to great interest in the mechanism of action of this class of drug. Although it has been well accepted that DPP-4 inhibitors lower glucose in part by increasing postprandial insulin secretion and suppressing fasting and postprandial hyperglucagonemia, recent studies have suggested that DPP-4 inhibition has other metabolically beneficial properties that are extrapancreatic in nature. This review explores the changes in DPP-4 expression and activity in metabolic disease states and discusses the metabolic consequences of DPP-4 inhibition on a systemic and tissue-specific basis. It concludes that there is considerable scientific evidence and a growing body of clinical evidence to suggest that DPP-4 inhibition would be beneficial in a number of metabolic disorders in addition to type 2 diabetes.</p>},
  author       = {Omar, Bilal A. and Ahrén, Bo},
  keyword      = {dipeptidyl peptidase-4,glucose,insulin,insulin sensitivity,liver},
  language     = {eng},
  number       = {3},
  pages        = {82--85},
  publisher    = {Lippincott Williams and Wilkins},
  series       = {Cardiovascular Endocrinology},
  title        = {Extrapancreatic contribution to glucose regulation by dipeptidyl peptidase 4 inhibition},
  url          = {http://dx.doi.org/10.1097/XCE.0000000000000088},
  volume       = {5},
  year         = {2016},
}