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Signals and regulators that govern Streptomyces development

McCormick, Joseph R. and Flärdh, Klas LU (2012) In FEMS Microbiology Reviews 36(1). p.206-231
Abstract
Streptomyces coelicolor is the genetically best characterized species of a populous genus belonging to the gram-positive Actinobacteria. Streptomycetes are filamentous soil organisms, well known for the production of a plethora of biologically active secondary metabolic compounds. The Streptomyces developmental life cycle is uniquely complex and involves coordinated multicellular development with both physiological and morphological differentiation of several cell types, culminating in the production of secondary metabolites and dispersal of mature spores. This review presents a current appreciation of the signaling mechanisms used to orchestrate the decision to undergo morphological differentiation, and the regulators and regulatory... (More)
Streptomyces coelicolor is the genetically best characterized species of a populous genus belonging to the gram-positive Actinobacteria. Streptomycetes are filamentous soil organisms, well known for the production of a plethora of biologically active secondary metabolic compounds. The Streptomyces developmental life cycle is uniquely complex and involves coordinated multicellular development with both physiological and morphological differentiation of several cell types, culminating in the production of secondary metabolites and dispersal of mature spores. This review presents a current appreciation of the signaling mechanisms used to orchestrate the decision to undergo morphological differentiation, and the regulators and regulatory networks that direct the intriguing development of multigenomic hyphae first to form specialized aerial hyphae and then to convert them into chains of dormant spores. This current view of S. coelicolor development is destined for rapid evolution as data from -omics studies shed light on gene regulatory networks, new genetic screens identify hitherto unknown players, and the resolution of our insights into the underlying cell biological processes steadily improve. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
differentiation, development, sporulation, cell division, chromosome, segregation
in
FEMS Microbiology Reviews
volume
36
issue
1
pages
206 - 231
publisher
Wiley-Blackwell
external identifiers
  • wos:000298061900011
  • scopus:83355162664
ISSN
1574-6976
DOI
10.1111/j.1574-6976.2011.00317.x
language
English
LU publication?
yes
id
e4f67488-b092-42d3-ba61-0389ed5610aa (old id 2425525)
date added to LUP
2012-03-23 09:53:46
date last changed
2017-11-12 03:10:44
@article{e4f67488-b092-42d3-ba61-0389ed5610aa,
  abstract     = {Streptomyces coelicolor is the genetically best characterized species of a populous genus belonging to the gram-positive Actinobacteria. Streptomycetes are filamentous soil organisms, well known for the production of a plethora of biologically active secondary metabolic compounds. The Streptomyces developmental life cycle is uniquely complex and involves coordinated multicellular development with both physiological and morphological differentiation of several cell types, culminating in the production of secondary metabolites and dispersal of mature spores. This review presents a current appreciation of the signaling mechanisms used to orchestrate the decision to undergo morphological differentiation, and the regulators and regulatory networks that direct the intriguing development of multigenomic hyphae first to form specialized aerial hyphae and then to convert them into chains of dormant spores. This current view of S. coelicolor development is destined for rapid evolution as data from -omics studies shed light on gene regulatory networks, new genetic screens identify hitherto unknown players, and the resolution of our insights into the underlying cell biological processes steadily improve.},
  author       = {McCormick, Joseph R. and Flärdh, Klas},
  issn         = {1574-6976},
  keyword      = {differentiation,development,sporulation,cell division,chromosome,segregation},
  language     = {eng},
  number       = {1},
  pages        = {206--231},
  publisher    = {Wiley-Blackwell},
  series       = {FEMS Microbiology Reviews},
  title        = {Signals and regulators that govern Streptomyces development},
  url          = {http://dx.doi.org/10.1111/j.1574-6976.2011.00317.x},
  volume       = {36},
  year         = {2012},
}