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Dietary oats and modulation of atherogenic pathways.

Andersson, Kristina E LU and Hellstrand, Per LU (2012) In Molecular Nutrition and Food Research 56(7). p.1003-1013
Abstract
Consumption of oats has long been known to lower plasma total and low-density lipoprotein (LDL) cholesterol levels, an effect usually attributed to the soluble fibers β-glucans. On the basis of this cholesterol-lowering effect, oats are ascribed cardiovascular health-promoting properties. However, besides cholesterol levels, effects of oats on parameters relating to atherosclerosis development have not been extensively investigated. Since oxidation of lipoproteins and inflammation are characteristics of atherosclerosis in addition to lipid accumulation in the vessel wall, micronutrients in oats (phytochemicals) with antioxidative and anti-inflammatory properties may contribute to an atheroprotective action. Here, we summarize evidence on... (More)
Consumption of oats has long been known to lower plasma total and low-density lipoprotein (LDL) cholesterol levels, an effect usually attributed to the soluble fibers β-glucans. On the basis of this cholesterol-lowering effect, oats are ascribed cardiovascular health-promoting properties. However, besides cholesterol levels, effects of oats on parameters relating to atherosclerosis development have not been extensively investigated. Since oxidation of lipoproteins and inflammation are characteristics of atherosclerosis in addition to lipid accumulation in the vessel wall, micronutrients in oats (phytochemicals) with antioxidative and anti-inflammatory properties may contribute to an atheroprotective action. Here, we summarize evidence on antiatherogenic properties of oats obtained from in vitro assays, animal experiments, and human studies. Possible effects involving anti-inflammatory and antioxidative actions, as well as preservation of endothelial function, are considered in addition to those related to reduction of plasma cholesterol. Since results of in vitro assays with isolated oat components are difficult to compare with effects of whole oats in humans and experimental animals, more observational studies with isolated oat components or fractions of oats are warranted. Also, there is a lack of epidemiological studies focusing on effects of oat intake on the cardiovascular disease panorama. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Molecular Nutrition and Food Research
volume
56
issue
7
pages
1003 - 1013
publisher
John Wiley & Sons
external identifiers
  • wos:000306005700002
  • pmid:22438057
  • scopus:84863543188
ISSN
1613-4133
DOI
10.1002/mnfr.201100706
language
English
LU publication?
yes
id
b6abb84f-b990-4709-bbc4-8cb4f9b08442 (old id 2431555)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22438057?dopt=Abstract
date added to LUP
2012-04-03 12:52:07
date last changed
2017-11-12 03:09:33
@article{b6abb84f-b990-4709-bbc4-8cb4f9b08442,
  abstract     = {Consumption of oats has long been known to lower plasma total and low-density lipoprotein (LDL) cholesterol levels, an effect usually attributed to the soluble fibers β-glucans. On the basis of this cholesterol-lowering effect, oats are ascribed cardiovascular health-promoting properties. However, besides cholesterol levels, effects of oats on parameters relating to atherosclerosis development have not been extensively investigated. Since oxidation of lipoproteins and inflammation are characteristics of atherosclerosis in addition to lipid accumulation in the vessel wall, micronutrients in oats (phytochemicals) with antioxidative and anti-inflammatory properties may contribute to an atheroprotective action. Here, we summarize evidence on antiatherogenic properties of oats obtained from in vitro assays, animal experiments, and human studies. Possible effects involving anti-inflammatory and antioxidative actions, as well as preservation of endothelial function, are considered in addition to those related to reduction of plasma cholesterol. Since results of in vitro assays with isolated oat components are difficult to compare with effects of whole oats in humans and experimental animals, more observational studies with isolated oat components or fractions of oats are warranted. Also, there is a lack of epidemiological studies focusing on effects of oat intake on the cardiovascular disease panorama.},
  author       = {Andersson, Kristina E and Hellstrand, Per},
  issn         = {1613-4133},
  language     = {eng},
  number       = {7},
  pages        = {1003--1013},
  publisher    = {John Wiley & Sons},
  series       = {Molecular Nutrition and Food Research},
  title        = {Dietary oats and modulation of atherogenic pathways.},
  url          = {http://dx.doi.org/10.1002/mnfr.201100706},
  volume       = {56},
  year         = {2012},
}