Genetic Variation in the Glucose-Dependent Insulinotropic Polypeptide Receptor Modifies the Association between Carbohydrate and Fat Intake and Risk of Type 2 Diabetes in the Malmo Diet and Cancer Cohort.

Sonestedt, Emily; Lyssenko, Valeriya; Ericson, Ulrika; Gullberg, Bo; Wirfält, Elisabet; Groop, Leif; Orho-Melander, Marju

Genetic Variation in the Glucose-Dependent Insulinotropic Polypeptide Receptor Modifies the Association between Carbohydrate and Fat Intake and Risk of Type 2 Diabetes in the Malmo Diet and Cancer Cohort.

Mark

; Lyssenko, Valeriya ^LU ; Ericson, Ulrika ^LU ; Gullberg, Bo ^LU ; Wirfält, Elisabet ^LU ; Groop, Leif ^LU and Orho-Melander, Marju ^LU (2012) In The Journal of clinical endocrinology and metabolism 97(5). p.810-818

Abstract: Context:A common genetic variant (rs10423928, A-allele) in the glucose-dependent insulinotropic polypeptide receptor gene (GIPR) is associated with decreased insulin secretion. Glucose-dependent insulinotropic polypeptide is secreted after food consumption and gipr knockout mice fed a high-fat diet are protected against obesity and disturbances in glucose homeostasis.

Objective:Our objective was to examine the interactions between rs10423928 and macronutrients and fiber intakes on body mass index and type 2 diabetes risk.Design, Setting, and Participants:Among nondiabetic subjects in the Swedish population-based Malmö Diet and Cancer cohort (n = 24,840; 45-74 yr), 1541 diabetes cases were identified during 12 yr of... (More); Context:A common genetic variant (rs10423928, A-allele) in the glucose-dependent insulinotropic polypeptide receptor gene (GIPR) is associated with decreased insulin secretion. Glucose-dependent insulinotropic polypeptide is secreted after food consumption and gipr knockout mice fed a high-fat diet are protected against obesity and disturbances in glucose homeostasis.

Objective:Our objective was to examine the interactions between rs10423928 and macronutrients and fiber intakes on body mass index and type 2 diabetes risk.Design, Setting, and Participants:Among nondiabetic subjects in the Swedish population-based Malmö Diet and Cancer cohort (n = 24,840; 45-74 yr), 1541 diabetes cases were identified during 12 yr of follow-up. Dietary intakes were assessed using a diet history method.

Main Outcome Measure:Incident type 2 diabetes was identified through registers.Results:There was no indication that dietary intakes significantly modify the association between GIPR genotype and body mass index (P interaction >0.08). We observed significant interactions between GIPR genotype and quintiles of carbohydrate (P = 0.0005) and fat intake (P = 0.0006) on incident type 2 diabetes. The TT-genotype carriers within the highest compared with the lowest carbohydrate quintile were at 23% (95% confidence interval = 5-39%) decreased type 2 diabetes risk. In contrast, AA-genotype carriers in the highest compared with the lowest fat quintile were at 69% (95% confidence interval = 29-86%) decreased risk.

Conclusions:Our prospective, observational study indicates that the type 2 diabetes risk by dietary intake of carbohydrate and fat may be dependent on GIPR genotype. In line with results in gipr knockout mice, AA-genotype carriers consuming high-fat low-carbohydrate diets had reduced type 2 diabetes risk, whereas high-carbohydrate low-fat diets benefitted the two thirds of population homozygous for the T-allele. (Less)

Please use this url to cite or link to this publication: https://lup.lub.lu.se/record/2432153

author

Sonestedt, Emily ^LU

; Lyssenko, Valeriya ^LU ; Ericson, Ulrika ^LU ; Gullberg, Bo ^LU ; Wirfält, Elisabet ^LU ; Groop, Leif ^LU and Orho-Melander, Marju ^LU

organization

publishing date

2012

type

Contribution to journal

publication status

published

subject

Endocrinology and Diabetes

in

The Journal of clinical endocrinology and metabolism

volume

97

issue

5

pages

810 - 818

publisher

Oxford University Press

external identifiers

wos:000303915900018
pmid:22399504
scopus:84860733554
pmid:22399504

ISSN

1945-7197

DOI

10.1210/jc.2011-2444

language

English

LU publication?

yes

id

4663b3ed-5ae6-4770-8c3b-395b12a7d31c (old id 2432153)

alternative location

http://www.ncbi.nlm.nih.gov/pubmed/22399504?dopt=Abstract

date added to LUP

2016-04-01 12:53:14

date last changed

2024-03-12 19:50:58

@article{4663b3ed-5ae6-4770-8c3b-395b12a7d31c,
  abstract     = {{Context:A common genetic variant (rs10423928, A-allele) in the glucose-dependent insulinotropic polypeptide receptor gene (GIPR) is associated with decreased insulin secretion. Glucose-dependent insulinotropic polypeptide is secreted after food consumption and gipr knockout mice fed a high-fat diet are protected against obesity and disturbances in glucose homeostasis.<br/><br>
<br/><br>
Objective:Our objective was to examine the interactions between rs10423928 and macronutrients and fiber intakes on body mass index and type 2 diabetes risk.Design, Setting, and Participants:Among nondiabetic subjects in the Swedish population-based Malmö Diet and Cancer cohort (n = 24,840; 45-74 yr), 1541 diabetes cases were identified during 12 yr of follow-up. Dietary intakes were assessed using a diet history method.<br/><br>
<br/><br>
Main Outcome Measure:Incident type 2 diabetes was identified through registers.Results:There was no indication that dietary intakes significantly modify the association between GIPR genotype and body mass index (P interaction &gt;0.08). We observed significant interactions between GIPR genotype and quintiles of carbohydrate (P = 0.0005) and fat intake (P = 0.0006) on incident type 2 diabetes. The TT-genotype carriers within the highest compared with the lowest carbohydrate quintile were at 23% (95% confidence interval = 5-39%) decreased type 2 diabetes risk. In contrast, AA-genotype carriers in the highest compared with the lowest fat quintile were at 69% (95% confidence interval = 29-86%) decreased risk.<br/><br>
<br/><br>
Conclusions:Our prospective, observational study indicates that the type 2 diabetes risk by dietary intake of carbohydrate and fat may be dependent on GIPR genotype. In line with results in gipr knockout mice, AA-genotype carriers consuming high-fat low-carbohydrate diets had reduced type 2 diabetes risk, whereas high-carbohydrate low-fat diets benefitted the two thirds of population homozygous for the T-allele.}},
  author       = {{Sonestedt, Emily and Lyssenko, Valeriya and Ericson, Ulrika and Gullberg, Bo and Wirfält, Elisabet and Groop, Leif and Orho-Melander, Marju}},
  issn         = {{1945-7197}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{810--818}},
  publisher    = {{Oxford University Press}},
  series       = {{The Journal of clinical endocrinology and metabolism}},
  title        = {{Genetic Variation in the Glucose-Dependent Insulinotropic Polypeptide Receptor Modifies the Association between Carbohydrate and Fat Intake and Risk of Type 2 Diabetes in the Malmo Diet and Cancer Cohort.}},
  url          = {{https://lup.lub.lu.se/search/files/3029386/2856127.pdf}},
  doi          = {{10.1210/jc.2011-2444}},
  volume       = {{97}},
  year         = {{2012}},
}

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Genetic Variation in the Glucose-Dependent Insulinotropic Polypeptide Receptor Modifies the Association between Carbohydrate and Fat Intake and Risk of Type 2 Diabetes in the Malmo Diet and Cancer Cohort.