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Potential biomarkers for early detection of pancreatic ductal adenocarcinoma

Kriz, D. LU ; Ansari, D. LU and Andersson, R. LU (2020) In Clinical and Translational Oncology 22(12). p.2170-2174
Abstract

Pancreatic cancer has the highest mortality amongst all major organ cancers. Early detection is key to reduce deaths related to pancreatic cancer. However, early detection has been challenged by the lack of non-invasive biomarkers with enough sensitivity and specificity to allow for screening. The gold standard is still carbohydrate antigen (CA 19-9), against which all new biomarkers must be evaluated. In this paper, we describe recent progress in the development of new pancreatic cancer biomarkers, focusing on proteins, metabolites, and genetic and epigenetic biomarkers. Although several promising biomarkers have been identified, they are all derived from retrospective studies and additional prospective studies are needed to confirm... (More)

Pancreatic cancer has the highest mortality amongst all major organ cancers. Early detection is key to reduce deaths related to pancreatic cancer. However, early detection has been challenged by the lack of non-invasive biomarkers with enough sensitivity and specificity to allow for screening. The gold standard is still carbohydrate antigen (CA 19-9), against which all new biomarkers must be evaluated. In this paper, we describe recent progress in the development of new pancreatic cancer biomarkers, focusing on proteins, metabolites, and genetic and epigenetic biomarkers. Although several promising biomarkers have been identified, they are all derived from retrospective studies and additional prospective studies are needed to confirm their clinical validity.

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Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Biomarkers, Early detection, Pancreatic cancer, Sensitivity, Specificity
in
Clinical and Translational Oncology
volume
22
issue
12
pages
5 pages
publisher
Springer
external identifiers
  • pmid:32447642
  • scopus:85085014619
ISSN
1699-048X
DOI
10.1007/s12094-020-02372-0
language
English
LU publication?
yes
id
243adec8-fed5-4ae8-ae3c-9ffd5adec52e
date added to LUP
2020-06-25 14:48:26
date last changed
2024-04-03 09:17:37
@article{243adec8-fed5-4ae8-ae3c-9ffd5adec52e,
  abstract     = {{<p>Pancreatic cancer has the highest mortality amongst all major organ cancers. Early detection is key to reduce deaths related to pancreatic cancer. However, early detection has been challenged by the lack of non-invasive biomarkers with enough sensitivity and specificity to allow for screening. The gold standard is still carbohydrate antigen (CA 19-9), against which all new biomarkers must be evaluated. In this paper, we describe recent progress in the development of new pancreatic cancer biomarkers, focusing on proteins, metabolites, and genetic and epigenetic biomarkers. Although several promising biomarkers have been identified, they are all derived from retrospective studies and additional prospective studies are needed to confirm their clinical validity.</p>}},
  author       = {{Kriz, D. and Ansari, D. and Andersson, R.}},
  issn         = {{1699-048X}},
  keywords     = {{Biomarkers; Early detection; Pancreatic cancer; Sensitivity; Specificity}},
  language     = {{eng}},
  number       = {{12}},
  pages        = {{2170--2174}},
  publisher    = {{Springer}},
  series       = {{Clinical and Translational Oncology}},
  title        = {{Potential biomarkers for early detection of pancreatic ductal adenocarcinoma}},
  url          = {{http://dx.doi.org/10.1007/s12094-020-02372-0}},
  doi          = {{10.1007/s12094-020-02372-0}},
  volume       = {{22}},
  year         = {{2020}},
}