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Effect of alpha-ketoglutarate given to pregnant sows on the development of the humerus and femur in newborns

Sliwa, E; Kowalik, S; Tatara, MR; Krupski, W; Majcher, P; Luszczewska-Sierakowska, I; Pierzynowski, Stefan LU and Studzinski, T (2005) In Bulletin of the Veterinary Institute in Puławy 49(1). p.117-120
Abstract
Alpha-ketoglutarate (AKG) was given to pregnant sows every day starting from the 91(st) d of pregnancy to farrowing. At the same time control pregnant sows were treated in the same way with physiological saline (PhS). Newborn piglets from the experimental (AKG) and control (PhS) mothers were euthanised in 1 h after their birth, and the femora and humeri were isolated and frozen at -25 degrees C until further analyses. Using quantitative computed tomography (QCT) method, volumetric bone density of the cortical and trabecular bone compartments were estimated. Moreover, geometrical and mechanical parameters of the bones and the level of osteocalcin and alkaline phosphatase activity in serum were determined. It was found that the... (More)
Alpha-ketoglutarate (AKG) was given to pregnant sows every day starting from the 91(st) d of pregnancy to farrowing. At the same time control pregnant sows were treated in the same way with physiological saline (PhS). Newborn piglets from the experimental (AKG) and control (PhS) mothers were euthanised in 1 h after their birth, and the femora and humeri were isolated and frozen at -25 degrees C until further analyses. Using quantitative computed tomography (QCT) method, volumetric bone density of the cortical and trabecular bone compartments were estimated. Moreover, geometrical and mechanical parameters of the bones and the level of osteocalcin and alkaline phosphatase activity in serum were determined. It was found that the administration of AKG to pregnant sows during 24 d before parturition decreased bone density in their newborns. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
alpha-ketoglutarate, piglets, sow, pregnancy, bone formation
in
Bulletin of the Veterinary Institute in Puławy
volume
49
issue
1
pages
117 - 120
publisher
National Veterinary Research Institute
external identifiers
  • wos:000228098700023
  • scopus:19344377948
ISSN
0042-4870
language
English
LU publication?
yes
id
f98a451f-a4ab-469e-ad4c-defb1f78069e (old id 246773)
alternative location
http://www.piwet.pulawy.pl/doc/biuletyn_49-1/23_sliwa.pdf
date added to LUP
2007-08-13 09:21:57
date last changed
2017-07-09 04:19:35
@article{f98a451f-a4ab-469e-ad4c-defb1f78069e,
  abstract     = {Alpha-ketoglutarate (AKG) was given to pregnant sows every day starting from the 91(st) d of pregnancy to farrowing. At the same time control pregnant sows were treated in the same way with physiological saline (PhS). Newborn piglets from the experimental (AKG) and control (PhS) mothers were euthanised in 1 h after their birth, and the femora and humeri were isolated and frozen at -25 degrees C until further analyses. Using quantitative computed tomography (QCT) method, volumetric bone density of the cortical and trabecular bone compartments were estimated. Moreover, geometrical and mechanical parameters of the bones and the level of osteocalcin and alkaline phosphatase activity in serum were determined. It was found that the administration of AKG to pregnant sows during 24 d before parturition decreased bone density in their newborns.},
  author       = {Sliwa, E and Kowalik, S and Tatara, MR and Krupski, W and Majcher, P and Luszczewska-Sierakowska, I and Pierzynowski, Stefan and Studzinski, T},
  issn         = {0042-4870},
  keyword      = {alpha-ketoglutarate,piglets,sow,pregnancy,bone formation},
  language     = {eng},
  number       = {1},
  pages        = {117--120},
  publisher    = {National Veterinary Research Institute},
  series       = {Bulletin of the Veterinary Institute in Puławy},
  title        = {Effect of alpha-ketoglutarate given to pregnant sows on the development of the humerus and femur in newborns},
  volume       = {49},
  year         = {2005},
}