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Quality of Life and the Effect of Memantine in Dementia with Lewy Bodies and Parkinson's Disease Dementia.

Larsson, Victoria LU ; Engedal, Knut; Aarsland, Dag; Wattmo, Carina LU ; Minthon, Lennart LU and Londos, Elisabet LU (2011) In Dementia and Geriatric Cognitive Disorders 32(4). p.227-234
Abstract
Aim: To investigate quality of life (QOL) and the effect of memantine treatment in patients with Lewy body dementias. Methods: A secondary analysis of a randomized controlled study in 70 patients with Parkinson's disease dementia (PDD) or dementia with Lewy bodies (DLB) over 24 weeks using caregiver-rated QOL-Alzheimer's disease (AD) in domains according to the WHO's classification of health. Results: Baseline QOL shows lower ratings for body functions over environmental factors in DLB/PDD. Treatment with memantine significantly improves life as a whole compared to placebo and improves total QOL, body function and structure. Conclusion: This study shows that memantine improves QOL in Lewy body dementias. We also demonstrate important QOL... (More)
Aim: To investigate quality of life (QOL) and the effect of memantine treatment in patients with Lewy body dementias. Methods: A secondary analysis of a randomized controlled study in 70 patients with Parkinson's disease dementia (PDD) or dementia with Lewy bodies (DLB) over 24 weeks using caregiver-rated QOL-Alzheimer's disease (AD) in domains according to the WHO's classification of health. Results: Baseline QOL shows lower ratings for body functions over environmental factors in DLB/PDD. Treatment with memantine significantly improves life as a whole compared to placebo and improves total QOL, body function and structure. Conclusion: This study shows that memantine improves QOL in Lewy body dementias. We also demonstrate important QOL patterns which can be used in clinical practice. Copyright (C) 2011 S. Karger AG, Basel (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
quality of life, Dementia, Dementia with Lewy bodies, Parkinson's, Randomized controlled trial, disease dementia
in
Dementia and Geriatric Cognitive Disorders
volume
32
issue
4
pages
227 - 234
publisher
Karger
external identifiers
  • wos:000300090700001
  • scopus:82055175125
ISSN
1420-8008
DOI
10.1159/000334523
language
English
LU publication?
yes
id
7ccfb13a-99eb-469a-ac86-ada2434e876a (old id 2494160)
date added to LUP
2012-05-08 08:10:34
date last changed
2017-04-23 03:21:13
@article{7ccfb13a-99eb-469a-ac86-ada2434e876a,
  abstract     = {Aim: To investigate quality of life (QOL) and the effect of memantine treatment in patients with Lewy body dementias. Methods: A secondary analysis of a randomized controlled study in 70 patients with Parkinson's disease dementia (PDD) or dementia with Lewy bodies (DLB) over 24 weeks using caregiver-rated QOL-Alzheimer's disease (AD) in domains according to the WHO's classification of health. Results: Baseline QOL shows lower ratings for body functions over environmental factors in DLB/PDD. Treatment with memantine significantly improves life as a whole compared to placebo and improves total QOL, body function and structure. Conclusion: This study shows that memantine improves QOL in Lewy body dementias. We also demonstrate important QOL patterns which can be used in clinical practice. Copyright (C) 2011 S. Karger AG, Basel},
  author       = {Larsson, Victoria and Engedal, Knut and Aarsland, Dag and Wattmo, Carina and Minthon, Lennart and Londos, Elisabet},
  issn         = {1420-8008},
  keyword      = {quality of life,Dementia,Dementia with Lewy bodies,Parkinson's,Randomized controlled trial,disease dementia},
  language     = {eng},
  number       = {4},
  pages        = {227--234},
  publisher    = {Karger},
  series       = {Dementia and Geriatric Cognitive Disorders},
  title        = {Quality of Life and the Effect of Memantine in Dementia with Lewy Bodies and Parkinson's Disease Dementia.},
  url          = {http://dx.doi.org/10.1159/000334523},
  volume       = {32},
  year         = {2011},
}