Power and limits of modern cancer diagnostics: cancer of unknown primary
(2012) In Annals of Oncology 23(3). p.760-764- Abstract
- Background: Cancer of unknown primary (CUP) is diagnosed at a metastatic stage but no diagnostic effort is spared to find the primary cancers because these will guide the treatment. Consequently, the diagnostic work-up for CUP is more comprehensive than for any other cancer, resulting in detection of second cancers unrelated to CUP. We want to use the detection rate of second cancers as a measure of efficacy of the diagnostic modalities in finding tumors, assuming that the detection rates have increased with modern technologies. Patients and methods: The number of CUP patients identified in the nation-wide Swedish Database was 28 574 and relative risks (RRs) for second cancers were recorded in three periods from 1980 through 2008. The... (More)
- Background: Cancer of unknown primary (CUP) is diagnosed at a metastatic stage but no diagnostic effort is spared to find the primary cancers because these will guide the treatment. Consequently, the diagnostic work-up for CUP is more comprehensive than for any other cancer, resulting in detection of second cancers unrelated to CUP. We want to use the detection rate of second cancers as a measure of efficacy of the diagnostic modalities in finding tumors, assuming that the detection rates have increased with modern technologies. Patients and methods: The number of CUP patients identified in the nation-wide Swedish Database was 28 574 and relative risks (RRs) for second cancers were recorded in three periods from 1980 through 2008. The first 5 months after CUP were considered critical for second cancers to be diagnosed during the intense work-up for CUP. Results: Among second cancers, diagnosable by computed tomography or magnetic resonance imaging, there was a large 6.80-fold increase in RR immediately following CUP diagnosis from the period 1980-1989 to 2000-2008. Over the same periods, the increase in in situ tumors was 7.16-fold. Conclusion: These data suggest that improvements in the resolution and availability of powerful imaging techniques result in increasingly sensitive detection of tumors. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2494884
- author
- Hemminki, Kari LU ; Liu, H. ; Heminki, A. and Sundquist, Jan LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- cancer of unknown primary, modern diagnostics, relative risks
- in
- Annals of Oncology
- volume
- 23
- issue
- 3
- pages
- 760 - 764
- publisher
- Oxford University Press
- external identifiers
-
- wos:000300733300033
- scopus:84863244155
- pmid:21821544
- ISSN
- 1569-8041
- DOI
- 10.1093/annonc/mdr369
- language
- English
- LU publication?
- yes
- id
- 93dfd19f-1afb-4b43-95ea-530b4c8c3d01 (old id 2494884)
- date added to LUP
- 2016-04-01 14:50:11
- date last changed
- 2022-01-28 02:47:48
@article{93dfd19f-1afb-4b43-95ea-530b4c8c3d01,
abstract = {{Background: Cancer of unknown primary (CUP) is diagnosed at a metastatic stage but no diagnostic effort is spared to find the primary cancers because these will guide the treatment. Consequently, the diagnostic work-up for CUP is more comprehensive than for any other cancer, resulting in detection of second cancers unrelated to CUP. We want to use the detection rate of second cancers as a measure of efficacy of the diagnostic modalities in finding tumors, assuming that the detection rates have increased with modern technologies. Patients and methods: The number of CUP patients identified in the nation-wide Swedish Database was 28 574 and relative risks (RRs) for second cancers were recorded in three periods from 1980 through 2008. The first 5 months after CUP were considered critical for second cancers to be diagnosed during the intense work-up for CUP. Results: Among second cancers, diagnosable by computed tomography or magnetic resonance imaging, there was a large 6.80-fold increase in RR immediately following CUP diagnosis from the period 1980-1989 to 2000-2008. Over the same periods, the increase in in situ tumors was 7.16-fold. Conclusion: These data suggest that improvements in the resolution and availability of powerful imaging techniques result in increasingly sensitive detection of tumors.}},
author = {{Hemminki, Kari and Liu, H. and Heminki, A. and Sundquist, Jan}},
issn = {{1569-8041}},
keywords = {{cancer of unknown primary; modern diagnostics; relative risks}},
language = {{eng}},
number = {{3}},
pages = {{760--764}},
publisher = {{Oxford University Press}},
series = {{Annals of Oncology}},
title = {{Power and limits of modern cancer diagnostics: cancer of unknown primary}},
url = {{http://dx.doi.org/10.1093/annonc/mdr369}},
doi = {{10.1093/annonc/mdr369}},
volume = {{23}},
year = {{2012}},
}