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Power and limits of modern cancer diagnostics: cancer of unknown primary

Hemminki, Kari LU ; Liu, H.; Heminki, A. and Sundquist, Jan LU (2012) In Annals of Oncology 23(3). p.760-764
Abstract
Background: Cancer of unknown primary (CUP) is diagnosed at a metastatic stage but no diagnostic effort is spared to find the primary cancers because these will guide the treatment. Consequently, the diagnostic work-up for CUP is more comprehensive than for any other cancer, resulting in detection of second cancers unrelated to CUP. We want to use the detection rate of second cancers as a measure of efficacy of the diagnostic modalities in finding tumors, assuming that the detection rates have increased with modern technologies. Patients and methods: The number of CUP patients identified in the nation-wide Swedish Database was 28 574 and relative risks (RRs) for second cancers were recorded in three periods from 1980 through 2008. The... (More)
Background: Cancer of unknown primary (CUP) is diagnosed at a metastatic stage but no diagnostic effort is spared to find the primary cancers because these will guide the treatment. Consequently, the diagnostic work-up for CUP is more comprehensive than for any other cancer, resulting in detection of second cancers unrelated to CUP. We want to use the detection rate of second cancers as a measure of efficacy of the diagnostic modalities in finding tumors, assuming that the detection rates have increased with modern technologies. Patients and methods: The number of CUP patients identified in the nation-wide Swedish Database was 28 574 and relative risks (RRs) for second cancers were recorded in three periods from 1980 through 2008. The first 5 months after CUP were considered critical for second cancers to be diagnosed during the intense work-up for CUP. Results: Among second cancers, diagnosable by computed tomography or magnetic resonance imaging, there was a large 6.80-fold increase in RR immediately following CUP diagnosis from the period 1980-1989 to 2000-2008. Over the same periods, the increase in in situ tumors was 7.16-fold. Conclusion: These data suggest that improvements in the resolution and availability of powerful imaging techniques result in increasingly sensitive detection of tumors. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cancer of unknown primary, modern diagnostics, relative risks
in
Annals of Oncology
volume
23
issue
3
pages
760 - 764
publisher
Oxford University Press
external identifiers
  • wos:000300733300033
  • scopus:84863244155
ISSN
1569-8041
DOI
10.1093/annonc/mdr369
language
English
LU publication?
yes
id
93dfd19f-1afb-4b43-95ea-530b4c8c3d01 (old id 2494884)
date added to LUP
2012-05-07 14:10:24
date last changed
2017-08-27 04:59:01
@article{93dfd19f-1afb-4b43-95ea-530b4c8c3d01,
  abstract     = {Background: Cancer of unknown primary (CUP) is diagnosed at a metastatic stage but no diagnostic effort is spared to find the primary cancers because these will guide the treatment. Consequently, the diagnostic work-up for CUP is more comprehensive than for any other cancer, resulting in detection of second cancers unrelated to CUP. We want to use the detection rate of second cancers as a measure of efficacy of the diagnostic modalities in finding tumors, assuming that the detection rates have increased with modern technologies. Patients and methods: The number of CUP patients identified in the nation-wide Swedish Database was 28 574 and relative risks (RRs) for second cancers were recorded in three periods from 1980 through 2008. The first 5 months after CUP were considered critical for second cancers to be diagnosed during the intense work-up for CUP. Results: Among second cancers, diagnosable by computed tomography or magnetic resonance imaging, there was a large 6.80-fold increase in RR immediately following CUP diagnosis from the period 1980-1989 to 2000-2008. Over the same periods, the increase in in situ tumors was 7.16-fold. Conclusion: These data suggest that improvements in the resolution and availability of powerful imaging techniques result in increasingly sensitive detection of tumors.},
  author       = {Hemminki, Kari and Liu, H. and Heminki, A. and Sundquist, Jan},
  issn         = {1569-8041},
  keyword      = {cancer of unknown primary,modern diagnostics,relative risks},
  language     = {eng},
  number       = {3},
  pages        = {760--764},
  publisher    = {Oxford University Press},
  series       = {Annals of Oncology},
  title        = {Power and limits of modern cancer diagnostics: cancer of unknown primary},
  url          = {http://dx.doi.org/10.1093/annonc/mdr369},
  volume       = {23},
  year         = {2012},
}