Concentrations of IGF-I and IGFBP-3 and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition
(2012) In British Journal of Cancer 106(5). p.1004-1010- Abstract
- BACKGROUND: Insulin-like growth factors (IGFs) and their binding proteins (BPs) regulate cell differentiation, proliferation and apoptosis, and may have a role in the aetiology of various cancers. Information on their role in pancreatic cancer is limited and was examined here in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition. METHODS: Serum concentrations of IGF-I and IGFBP-3 were measured using enzyme-linked immunosorbent assays in 422 cases and 422 controls matched on age, sex, study centre, recruitment date, and time since last meal. Conditional logistic regression was used to compute odds ratios (OR) and 95% confidence intervals (CI) adjusted for confounding variables. RESULTS:... (More)
- BACKGROUND: Insulin-like growth factors (IGFs) and their binding proteins (BPs) regulate cell differentiation, proliferation and apoptosis, and may have a role in the aetiology of various cancers. Information on their role in pancreatic cancer is limited and was examined here in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition. METHODS: Serum concentrations of IGF-I and IGFBP-3 were measured using enzyme-linked immunosorbent assays in 422 cases and 422 controls matched on age, sex, study centre, recruitment date, and time since last meal. Conditional logistic regression was used to compute odds ratios (OR) and 95% confidence intervals (CI) adjusted for confounding variables. RESULTS: Neither circulating levels of IGF-I (OR = 1.21, 95% CI 0.75-1.93 for top vs bottom quartile, P-trend 0.301), IGFBP-3 (OR = 1.00, 95% CI 0.66-1.51, P-trend 0.79), nor the molar IGF-I/IGFBP-3 ratio, an indicator of free IGF-I level (OR = 1.22, 95% CI 0.75-1.97, P-trend 0.27), were statistically significantly associated with the risk of pancreatic cancer. In a cross-classification, however, a high concentration of IGF-I with concurrently low levels of IGFBP-3 was related to an increased risk of pancreatic cancer (OR = 1.72, 95% CI 1.05-2.83; P-interaction = 0.154). CONCLUSION: On the basis of these results, circulating levels of components of the IGF axis do not appear to be the risk factors for pancreatic cancer. However, on the basis of the results of a subanalysis, it cannot be excluded that a relatively large amount of IGF-1 together with very low levels of IGFBP-3 might still be associated with an increase in pancreatic cancer risk. British Journal of Cancer (2012) 106, 1004-1010. doi:10.1038/bjc.2012.19 www.bjcancer.com Published online 7 February 2012 (C) 2012 Cancer Research UK (Less)
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- author
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- cohort study, IGFBP-3, pancreatic cancer, IGF-I
- in
- British Journal of Cancer
- volume
- 106
- issue
- 5
- pages
- 1004 - 1010
- publisher
- Nature Publishing Group
- external identifiers
-
- wos:000300894300030
- scopus:84857787958
- pmid:22315049
- ISSN
- 1532-1827
- DOI
- 10.1038/bjc.2012.19
- language
- English
- LU publication?
- yes
- id
- 383e3c74-dc63-447e-a4f0-eb69ad357de8 (old id 2517281)
- date added to LUP
- 2016-04-01 10:59:12
- date last changed
- 2022-04-28 03:30:56
@article{383e3c74-dc63-447e-a4f0-eb69ad357de8,
abstract = {{BACKGROUND: Insulin-like growth factors (IGFs) and their binding proteins (BPs) regulate cell differentiation, proliferation and apoptosis, and may have a role in the aetiology of various cancers. Information on their role in pancreatic cancer is limited and was examined here in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition. METHODS: Serum concentrations of IGF-I and IGFBP-3 were measured using enzyme-linked immunosorbent assays in 422 cases and 422 controls matched on age, sex, study centre, recruitment date, and time since last meal. Conditional logistic regression was used to compute odds ratios (OR) and 95% confidence intervals (CI) adjusted for confounding variables. RESULTS: Neither circulating levels of IGF-I (OR = 1.21, 95% CI 0.75-1.93 for top vs bottom quartile, P-trend 0.301), IGFBP-3 (OR = 1.00, 95% CI 0.66-1.51, P-trend 0.79), nor the molar IGF-I/IGFBP-3 ratio, an indicator of free IGF-I level (OR = 1.22, 95% CI 0.75-1.97, P-trend 0.27), were statistically significantly associated with the risk of pancreatic cancer. In a cross-classification, however, a high concentration of IGF-I with concurrently low levels of IGFBP-3 was related to an increased risk of pancreatic cancer (OR = 1.72, 95% CI 1.05-2.83; P-interaction = 0.154). CONCLUSION: On the basis of these results, circulating levels of components of the IGF axis do not appear to be the risk factors for pancreatic cancer. However, on the basis of the results of a subanalysis, it cannot be excluded that a relatively large amount of IGF-1 together with very low levels of IGFBP-3 might still be associated with an increase in pancreatic cancer risk. British Journal of Cancer (2012) 106, 1004-1010. doi:10.1038/bjc.2012.19 www.bjcancer.com Published online 7 February 2012 (C) 2012 Cancer Research UK}},
author = {{Rohrmann, S. and Grote, V. A. and Becker, S. and Rinaldi, S. and Tjonneland, A. and Roswall, N. and Gronbaek, H. and Overvad, K. and Boutron-Ruault, M. C. and Clavel-Chapelon, F. and Racine, A. and Teucher, B. and Boeing, H. and Drogan, D. and Dilis, V. and Lagiou, P. and Trichopoulou, A. and Palli, D. and Tagliabue, G. and Tumino, R. and Vineis, P. and Mattiello, A. and Rodriguez, L. and Duell, E. J. and Molina-Montes, E. and Dorronsoro, M. and Huerta, J-M and Ardanaz, E. and Jeurnink, S. and Peeters, P. H. M. and Lindkvist, B. and Johansen, Dorthe and Sund, M. and Ye, W. and Khaw, K-T and Wareham, N. J. and Allen, N. E. and Crowe, F. L. and Fedirko, V. and Jenab, M. and Michaud, D. S. and Norat, T. and Riboli, E. and Bueno-de-Mesquita, H. B. and Kaaks, R.}},
issn = {{1532-1827}},
keywords = {{cohort study; IGFBP-3; pancreatic cancer; IGF-I}},
language = {{eng}},
number = {{5}},
pages = {{1004--1010}},
publisher = {{Nature Publishing Group}},
series = {{British Journal of Cancer}},
title = {{Concentrations of IGF-I and IGFBP-3 and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition}},
url = {{http://dx.doi.org/10.1038/bjc.2012.19}},
doi = {{10.1038/bjc.2012.19}},
volume = {{106}},
year = {{2012}},
}