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Ectopic Ependymal Cells in Striatum Accompany Neurogenesis in a Rat Model of Stroke.

Danilov, Alexandre LU ; Kokaia, Zaal LU and Lindvall, Olle LU (2012) In Neuroscience 214. p.159-170
Abstract
Stroke-induced neurogenesis originates from a neural stem cell (NSC) niche in subventricular zone (SVZ). In mice, NSCs are concentrated in a so-called "neurogenic spot" in the lateral angle area of SVZ. We aimed to identify the "neurogenic spot" in the rat SVZ and to characterize the cellular changes in the ependymal cell compartment in this area at different time points after middle cerebral artery occlusion. The majority of ependymal cells outlining the ventricular wall did not proliferate, and their numbers in the "neurogenic spot" declined at six and sixteen weeks after stroke. Cells with the ultrastructural properties of ependymal cells were detected in the adjacent striatum. The number of these ectopic ependymal cells correlated... (More)
Stroke-induced neurogenesis originates from a neural stem cell (NSC) niche in subventricular zone (SVZ). In mice, NSCs are concentrated in a so-called "neurogenic spot" in the lateral angle area of SVZ. We aimed to identify the "neurogenic spot" in the rat SVZ and to characterize the cellular changes in the ependymal cell compartment in this area at different time points after middle cerebral artery occlusion. The majority of ependymal cells outlining the ventricular wall did not proliferate, and their numbers in the "neurogenic spot" declined at six and sixteen weeks after stroke. Cells with the ultrastructural properties of ependymal cells were detected in the adjacent striatum. The number of these ectopic ependymal cells correlated positively with the magnitude of lateral ventriclar enlargement and negatively with the ependymal cell number in the "neurogenic spot". Ectopic ependymal cells were found along blood vessels, accumulated in the pericyst regions, and participated in scar formation but did not incorporate BrdU. We provide the first evidence for the occurrence of ectopic ependymal cells in the ischemic striatum following stroke. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Neuroscience
volume
214
pages
159 - 170
publisher
Elsevier
external identifiers
  • wos:000305547500014
  • pmid:22531371
  • scopus:84861830466
ISSN
1873-7544
DOI
10.1016/j.neuroscience.2012.03.062
language
English
LU publication?
yes
id
14ff5ae7-64f5-4c8e-82ec-ea90e3bdc180 (old id 2519065)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22531371?dopt=Abstract
date added to LUP
2012-05-07 11:49:38
date last changed
2017-10-22 04:53:24
@article{14ff5ae7-64f5-4c8e-82ec-ea90e3bdc180,
  abstract     = {Stroke-induced neurogenesis originates from a neural stem cell (NSC) niche in subventricular zone (SVZ). In mice, NSCs are concentrated in a so-called "neurogenic spot" in the lateral angle area of SVZ. We aimed to identify the "neurogenic spot" in the rat SVZ and to characterize the cellular changes in the ependymal cell compartment in this area at different time points after middle cerebral artery occlusion. The majority of ependymal cells outlining the ventricular wall did not proliferate, and their numbers in the "neurogenic spot" declined at six and sixteen weeks after stroke. Cells with the ultrastructural properties of ependymal cells were detected in the adjacent striatum. The number of these ectopic ependymal cells correlated positively with the magnitude of lateral ventriclar enlargement and negatively with the ependymal cell number in the "neurogenic spot". Ectopic ependymal cells were found along blood vessels, accumulated in the pericyst regions, and participated in scar formation but did not incorporate BrdU. We provide the first evidence for the occurrence of ectopic ependymal cells in the ischemic striatum following stroke.},
  author       = {Danilov, Alexandre and Kokaia, Zaal and Lindvall, Olle},
  issn         = {1873-7544},
  language     = {eng},
  pages        = {159--170},
  publisher    = {Elsevier},
  series       = {Neuroscience},
  title        = {Ectopic Ependymal Cells in Striatum Accompany Neurogenesis in a Rat Model of Stroke.},
  url          = {http://dx.doi.org/10.1016/j.neuroscience.2012.03.062},
  volume       = {214},
  year         = {2012},
}