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Tumors with non-functional RB1 are killed by reduced gamma-tubulin levels.

Ehlén, Åsa LU ; Rossello Castillo, Catalina Ana LU ; von Stedingk, Kristoffer LU ; Eklund, Greta LU ; Nilsson, Elise LU ; Pettersson, Helen LU ; Jirström, Karin LU and Alvarado-Kristensson, Maria LU (2012) In Journal of Biological Chemistry 287(21). p.17241-17247
Abstract
In various tumors inactivation of growth control is achieved by interfering with the RB1 signaling pathway. Here, we describe that RB1 and γ tubulin proteins moderate each other's expression by binding to their respective gene promoters. Simultaneous reduction of RB1 and γ tubulin protein levels result in an E2F1-dependent upregulation of apoptotic genes such as caspase 3. We report that in various tumors types, there is an inverse correlation between the expression levels of γ tubulin and RB1 and that in tumor cell lines with a non-functioning RB1, reduction of γ tubulin protein levels leads to induction of apoptosis. Thus, the RB1/γ tubulin signal network can be considered as a new target for cancer treatment.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Biological Chemistry
volume
287
issue
21
pages
17241 - 17247
publisher
ASBMB
external identifiers
  • pmid:22493456
  • wos:000306373000024
  • scopus:84861205944
ISSN
1083-351X
DOI
10.1074/jbc.M112.357038
language
English
LU publication?
yes
id
fc9841d0-9d91-4af3-bd7a-5c6e365fd551 (old id 2519610)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22493456?dopt=Abstract
date added to LUP
2012-05-06 14:55:58
date last changed
2017-08-11 13:44:21
@article{fc9841d0-9d91-4af3-bd7a-5c6e365fd551,
  abstract     = {In various tumors inactivation of growth control is achieved by interfering with the RB1 signaling pathway. Here, we describe that RB1 and γ tubulin proteins moderate each other's expression by binding to their respective gene promoters. Simultaneous reduction of RB1 and γ tubulin protein levels result in an E2F1-dependent upregulation of apoptotic genes such as caspase 3. We report that in various tumors types, there is an inverse correlation between the expression levels of γ tubulin and RB1 and that in tumor cell lines with a non-functioning RB1, reduction of γ tubulin protein levels leads to induction of apoptosis. Thus, the RB1/γ tubulin signal network can be considered as a new target for cancer treatment.},
  author       = {Ehlén, Åsa and Rossello Castillo, Catalina Ana and von Stedingk, Kristoffer and Eklund, Greta and Nilsson, Elise and Pettersson, Helen and Jirström, Karin and Alvarado-Kristensson, Maria},
  issn         = {1083-351X},
  language     = {eng},
  number       = {21},
  pages        = {17241--17247},
  publisher    = {ASBMB},
  series       = {Journal of Biological Chemistry},
  title        = {Tumors with non-functional RB1 are killed by reduced gamma-tubulin levels.},
  url          = {http://dx.doi.org/10.1074/jbc.M112.357038},
  volume       = {287},
  year         = {2012},
}