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Improving cerebrovascular function to increase neuronal recovery in neurodegeneration associated to cardiovascular disease

Vanherle, Lotte LU ; Matuskova, Hana LU ; Don-Doncow, Nicholas LU ; Uhl, Franziska LU and Meissner, Anja LU (2020) In Frontiers in cell and developmental biology 8.
Abstract
Mounting evidence indicates that the presence of cardiovascular disease (CVD) and risk factors elevates the incidence of cognitive impairment (CI) and dementia. CVD and associated decline in cardiovascular function can impair cerebral blood flow (CBF) regulation, leading to the disruption of oxygen and nutrient supply in the brain where limited intracellular energy storage capacity critically depends on CBF to sustain proper neuronal functioning. During hypertension and acute as well as chronic CVD, cerebral hypoperfusion and impaired cerebrovascular function are often associated with neurodegeneration and can lead to CI and dementia. Currently, all forms of neurodegeneration associated to CVD lack effective treatments, which highlights... (More)
Mounting evidence indicates that the presence of cardiovascular disease (CVD) and risk factors elevates the incidence of cognitive impairment (CI) and dementia. CVD and associated decline in cardiovascular function can impair cerebral blood flow (CBF) regulation, leading to the disruption of oxygen and nutrient supply in the brain where limited intracellular energy storage capacity critically depends on CBF to sustain proper neuronal functioning. During hypertension and acute as well as chronic CVD, cerebral hypoperfusion and impaired cerebrovascular function are often associated with neurodegeneration and can lead to CI and dementia. Currently, all forms of neurodegeneration associated to CVD lack effective treatments, which highlights the need to better understand specific mechanisms linking cerebrovascular dysfunction and CBF deficits to neurodegeneration. In this review, we discuss vascular targets that have already shown attenuation of neurodegeneration or CI associated to hypertension, heart failure (HF) and stroke by improving cerebrovascular function or CBF deficits. (Less)
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; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Frontiers in cell and developmental biology
volume
8
article number
53
publisher
Frontiers Media S. A.
external identifiers
  • pmid:32117979
  • scopus:85079756257
ISSN
2296-634X
DOI
10.3389/fcell.2020.00053
language
English
LU publication?
yes
id
2540d1f3-bf5d-4bda-b366-4b394cc51138
date added to LUP
2020-02-01 09:58:21
date last changed
2020-03-15 06:07:41
@article{2540d1f3-bf5d-4bda-b366-4b394cc51138,
  abstract     = {Mounting evidence indicates that the presence of cardiovascular disease (CVD) and risk factors elevates the incidence of cognitive impairment (CI) and dementia. CVD and associated decline in cardiovascular function can impair cerebral blood flow (CBF) regulation, leading to the disruption of oxygen and nutrient supply in the brain where limited intracellular energy storage capacity critically depends on CBF to sustain proper neuronal functioning. During hypertension and acute as well as chronic CVD, cerebral hypoperfusion and impaired cerebrovascular function are often associated with neurodegeneration and can lead to CI and dementia. Currently, all forms of neurodegeneration associated to CVD lack effective treatments, which highlights the need to better understand specific mechanisms linking cerebrovascular dysfunction and CBF deficits to neurodegeneration. In this review, we discuss vascular targets that have already shown attenuation of neurodegeneration or CI associated to hypertension, heart failure (HF) and stroke by improving cerebrovascular function or CBF deficits.},
  author       = {Vanherle, Lotte and Matuskova, Hana and Don-Doncow, Nicholas and Uhl, Franziska and Meissner, Anja},
  issn         = {2296-634X},
  language     = {eng},
  month        = {02},
  publisher    = {Frontiers Media S. A.},
  series       = {Frontiers in cell and developmental biology},
  title        = {Improving cerebrovascular function to increase neuronal recovery in neurodegeneration associated to cardiovascular disease},
  url          = {http://dx.doi.org/10.3389/fcell.2020.00053},
  doi          = {10.3389/fcell.2020.00053},
  volume       = {8},
  year         = {2020},
}