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Coffee and tea consumption and the risk of ovarian cancer: a prospective cohort study and updated meta-analysis

Braem, Marieke G. M.; Onland-Moret, N. Charlotte; Schouten, Leo J.; Tjonneland, Anne; Hansen, Louise; Dahm, Christina C.; Overvad, Kim; Lukanova, Annekatrin; Dossus, Laure and Floegel, Anna, et al. (2012) In American Journal of Clinical Nutrition 95(5). p.1172-1181
Abstract
Background: In 2007 the World Cancer Research Fund Report concluded that there was limited and inconsistent evidence for an effect of coffee and tea consumption on the risk of epithelial ovarian cancer (EOC). Objective: In the European Prospective Investigation into Cancer and Nutrition (EPIC), we aimed to investigate whether coffee intakes, tea intakes, or both are associated with the risk of EOC. Design: All women participating in the EPIC (n = 330,849) were included in this study. Data on coffee and tea consumption were collected through validated food-frequency questionnaires at baseline. HRs and 95% CIs were estimated by using Cox proportional hazards models. Furthermore, we performed an updated meta-analysis of all previous... (More)
Background: In 2007 the World Cancer Research Fund Report concluded that there was limited and inconsistent evidence for an effect of coffee and tea consumption on the risk of epithelial ovarian cancer (EOC). Objective: In the European Prospective Investigation into Cancer and Nutrition (EPIC), we aimed to investigate whether coffee intakes, tea intakes, or both are associated with the risk of EOC. Design: All women participating in the EPIC (n = 330,849) were included in this study. Data on coffee and tea consumption were collected through validated food-frequency questionnaires at baseline. HRs and 95% CIs were estimated by using Cox proportional hazards models. Furthermore, we performed an updated meta-analysis of all previous prospective studies until April 2011 by comparing the highest and lowest coffee- and tea-consumption categories as well as by using dose-response random-effects meta-regression analyses. Results: During a median follow-up of 11.7 y, 1244 women developed EOC. No association was observed between the risk of EOC and coffee consumption [HR: 1.05 (95% CI: 0.75, 1.46) for the top quintile compared with no intake] or tea consumption [HR: 1.07 (95% Cl: 0.78, 1.45) for the top quintile compared with no intake]. This lack of association between coffee and tea intake and EOC risk was confirmed by the results of our meta-analysis. Conclusion: Epidemiologic studies do not provide sufficient evidence to support an association between coffee and tea consumption and risk of ovarian cancer. Am J Clin Nutr 2012;95:1172-81. (Less)
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American Journal of Clinical Nutrition
volume
95
issue
5
pages
1172 - 1181
publisher
American Society for Clinical Nutrition
external identifiers
  • wos:000303140700023
  • scopus:84860298595
ISSN
1938-3207
DOI
10.3945/ajcn.111.026393
language
English
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yes
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8ef426b9-75e6-4ef4-913a-5ef354bc9c51 (old id 2563005)
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2012-06-01 08:47:59
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@article{8ef426b9-75e6-4ef4-913a-5ef354bc9c51,
  abstract     = {Background: In 2007 the World Cancer Research Fund Report concluded that there was limited and inconsistent evidence for an effect of coffee and tea consumption on the risk of epithelial ovarian cancer (EOC). Objective: In the European Prospective Investigation into Cancer and Nutrition (EPIC), we aimed to investigate whether coffee intakes, tea intakes, or both are associated with the risk of EOC. Design: All women participating in the EPIC (n = 330,849) were included in this study. Data on coffee and tea consumption were collected through validated food-frequency questionnaires at baseline. HRs and 95% CIs were estimated by using Cox proportional hazards models. Furthermore, we performed an updated meta-analysis of all previous prospective studies until April 2011 by comparing the highest and lowest coffee- and tea-consumption categories as well as by using dose-response random-effects meta-regression analyses. Results: During a median follow-up of 11.7 y, 1244 women developed EOC. No association was observed between the risk of EOC and coffee consumption [HR: 1.05 (95% CI: 0.75, 1.46) for the top quintile compared with no intake] or tea consumption [HR: 1.07 (95% Cl: 0.78, 1.45) for the top quintile compared with no intake]. This lack of association between coffee and tea intake and EOC risk was confirmed by the results of our meta-analysis. Conclusion: Epidemiologic studies do not provide sufficient evidence to support an association between coffee and tea consumption and risk of ovarian cancer. Am J Clin Nutr 2012;95:1172-81.},
  author       = {Braem, Marieke G. M. and Onland-Moret, N. Charlotte and Schouten, Leo J. and Tjonneland, Anne and Hansen, Louise and Dahm, Christina C. and Overvad, Kim and Lukanova, Annekatrin and Dossus, Laure and Floegel, Anna and Boeing, Heiner and Clavel-Chapelon, Francoise and Chabbert-Buffet, Nathalie and Fagherazzi, Guy and Trichopoulou, Antonia and Benetou, Vassiliki and Goufa, Ioulia and Pala, Valeria and Galasso, Rocco and Mattiello, Amalia and Sacerdote, Carlotta and Palli, Domenico and Tumino, Rosario and Gram, Inger T. and Lund, Eiliv and Gavrilyuk, Oxana and Sanchez, Maria-Jose and Quiros, Ramon and Gonzales, Carlos A. and Dorronsoro, Miren and Huerta Castano, Jose M. and Barricarte Gurrea, Aurelio and Idahl, Annika and Ohlson, Nina and Lundin, Eva and Jirström, Karin and Wirfält, Elisabet and Allen, Naomi E. and Tsilidis, Konstantinos K. and Kaw, Kay-Tee and Bueno-de-Mesquita, H. Bas and Dik, Vincent K. and Rinaldi, Sabina and Fedirko, Veronika and Norat, Teresa and Riboli, Elio and Kaaks, Rudolf and Peeters, Petra H. M.},
  issn         = {1938-3207},
  language     = {eng},
  number       = {5},
  pages        = {1172--1181},
  publisher    = {American Society for Clinical Nutrition},
  series       = {American Journal of Clinical Nutrition},
  title        = {Coffee and tea consumption and the risk of ovarian cancer: a prospective cohort study and updated meta-analysis},
  url          = {http://dx.doi.org/10.3945/ajcn.111.026393},
  volume       = {95},
  year         = {2012},
}