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Obstetric outcome in singletons after in vitro fertilization with cryopreserved/thawed embryos

Sazonova, Antonina; Källén, Karin LU ; Thurin-Kjellberg, Ann; Wennerholm, Ulla-Britt and Bergh, Christina (2012) In Human Reproduction 27(5). p.1343-1350
Abstract
There is increasing use of cryopreservation in IVF. This study compared singletons born after cryopreservation with singletons born after fresh IVF cycles and singletons born to women in the general population. Data were collected for Swedish IVF treatments during the years 20022006. All singletons from single embryo transfer (SET) and double embryo transfer (DET) after cryopreserved (n 2348) and fresh cycles (n 8944) were included and cross-linked with the Swedish Medical Birth Registry and compared with all singletons born after spontaneous conception (n 571 914). Main outcomes were preterm and very preterm birth and low and very low birthweight (VLBW). Other outcomes were small for gestational age, large for gestational age (LGA),... (More)
There is increasing use of cryopreservation in IVF. This study compared singletons born after cryopreservation with singletons born after fresh IVF cycles and singletons born to women in the general population. Data were collected for Swedish IVF treatments during the years 20022006. All singletons from single embryo transfer (SET) and double embryo transfer (DET) after cryopreserved (n 2348) and fresh cycles (n 8944) were included and cross-linked with the Swedish Medical Birth Registry and compared with all singletons born after spontaneous conception (n 571 914). Main outcomes were preterm and very preterm birth and low and very low birthweight (VLBW). Other outcomes were small for gestational age, large for gestational age (LGA), perinatal mortality and maternal outcomes. Singletons from cryopreserved SET/DET or cryopreserved SET had increased rates of extreme preterm birth compared with singletons from the general population. A lower rate of LBW was found for cryopreserved SET/DET singletons compared with singletons from fresh cycles; however, a higher rate of perinatal mortality was detected. The rates of LGA and macrosomia were increased for cryopreserved SET/DET singletons when compared with those from fresh cycles and the general population. For maternal outcomes, a higher rate of pre-eclampsia was noted for pregnancies from cryopreserved cycles compared with those from fresh cycles or the general population, but the rate of placenta praevia was lower in pregnancies from cryopreserved cycles compared with those from fresh cycles. The obstetric outcome of singletons after cryopreservation was slightly poorer when compared with the general population. In comparison with fresh cycles, the outcome varied. The finding of an increased rate of LGA after cryopreservation requires further study. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
IVF, singletons, cryopreservation, obstetric outcome
in
Human Reproduction
volume
27
issue
5
pages
1343 - 1350
publisher
Oxford University Press
external identifiers
  • wos:000303161900014
  • scopus:84860129066
ISSN
0268-1161
DOI
10.1093/humrep/des036
language
English
LU publication?
yes
id
99a792a7-96f9-44e5-8a31-d499badb6985 (old id 2563235)
date added to LUP
2012-06-01 08:48:21
date last changed
2017-09-17 04:21:23
@article{99a792a7-96f9-44e5-8a31-d499badb6985,
  abstract     = {There is increasing use of cryopreservation in IVF. This study compared singletons born after cryopreservation with singletons born after fresh IVF cycles and singletons born to women in the general population. Data were collected for Swedish IVF treatments during the years 20022006. All singletons from single embryo transfer (SET) and double embryo transfer (DET) after cryopreserved (n 2348) and fresh cycles (n 8944) were included and cross-linked with the Swedish Medical Birth Registry and compared with all singletons born after spontaneous conception (n 571 914). Main outcomes were preterm and very preterm birth and low and very low birthweight (VLBW). Other outcomes were small for gestational age, large for gestational age (LGA), perinatal mortality and maternal outcomes. Singletons from cryopreserved SET/DET or cryopreserved SET had increased rates of extreme preterm birth compared with singletons from the general population. A lower rate of LBW was found for cryopreserved SET/DET singletons compared with singletons from fresh cycles; however, a higher rate of perinatal mortality was detected. The rates of LGA and macrosomia were increased for cryopreserved SET/DET singletons when compared with those from fresh cycles and the general population. For maternal outcomes, a higher rate of pre-eclampsia was noted for pregnancies from cryopreserved cycles compared with those from fresh cycles or the general population, but the rate of placenta praevia was lower in pregnancies from cryopreserved cycles compared with those from fresh cycles. The obstetric outcome of singletons after cryopreservation was slightly poorer when compared with the general population. In comparison with fresh cycles, the outcome varied. The finding of an increased rate of LGA after cryopreservation requires further study.},
  author       = {Sazonova, Antonina and Källén, Karin and Thurin-Kjellberg, Ann and Wennerholm, Ulla-Britt and Bergh, Christina},
  issn         = {0268-1161},
  keyword      = {IVF,singletons,cryopreservation,obstetric outcome},
  language     = {eng},
  number       = {5},
  pages        = {1343--1350},
  publisher    = {Oxford University Press},
  series       = {Human Reproduction},
  title        = {Obstetric outcome in singletons after in vitro fertilization with cryopreserved/thawed embryos},
  url          = {http://dx.doi.org/10.1093/humrep/des036},
  volume       = {27},
  year         = {2012},
}