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Autoimmune disease and subsequent digestive tract cancer by histology

Hemminki, Kari LU ; Liu, Xiangdong LU ; Ji, Jianguang LU ; Sundquist, Jan LU and Sundquist, Kristina LU (2012) In Annals of Oncology 23(4). p.6-927
Abstract
Background: Dysregulation of the immune function in autoimmune diseases could potentially lead to cancer development and there is definite evidence linking some autoimmune mechanisms with cancer. We analyzed systematically the occurrence of histology-specific digestive tract cancers in patients diagnosed with 33 different autoimmune diseases in order to address the question of shared susceptibility. Patients and methods: Standardized incidence ratios (SIRs) were calculated for subsequent digestive tract cancers up to the year 2008 and in patients hospitalized for autoimmune disease after the year 1964. Results: Myasthenia gravis associated with five different cancers with SIRs ranging from 1.35 to 2.78. Pernicious anemia, Crohn disease,... (More)
Background: Dysregulation of the immune function in autoimmune diseases could potentially lead to cancer development and there is definite evidence linking some autoimmune mechanisms with cancer. We analyzed systematically the occurrence of histology-specific digestive tract cancers in patients diagnosed with 33 different autoimmune diseases in order to address the question of shared susceptibility. Patients and methods: Standardized incidence ratios (SIRs) were calculated for subsequent digestive tract cancers up to the year 2008 and in patients hospitalized for autoimmune disease after the year 1964. Results: Myasthenia gravis associated with five different cancers with SIRs ranging from 1.35 to 2.78. Pernicious anemia, Crohn disease, ulcerative colitis, systemic lupus erythematosis and psoriasis were also associated with cancers at multiple sites. Rheumatoid arthritis associated with no cancer and the standardized incidence ratio was decreased for colon adenocarcinoma, also in ankylosing spondylitis patients. Conclusions: Increased risks of cancer were observed in patients with several autoimmune diseases. Myasthenia gravis and pernicious anemia were associated with many cancers; this is possibly related to immunosuppressant medication in myasthenia gravis. The decreased risks in colon and rectal adenocarcinomas in rheumatoid arthritis and ankylosing spondylitis suggest underlying inflammatory mechanisms as the risks may have been suppressed by the use of anti-inflammatory medication. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cancer, digestive tract, autoimmune disease
in
Annals of Oncology
volume
23
issue
4
pages
6 - 927
publisher
Oxford University Press
external identifiers
  • wos:000302298000017
  • scopus:84859503625
ISSN
1569-8041
DOI
10.1093/annonc/mdr333
language
English
LU publication?
yes
id
65b79d00-cc3e-4407-ac97-bfe58bc0515d (old id 2574820)
date added to LUP
2012-06-01 09:34:48
date last changed
2017-08-27 05:04:09
@article{65b79d00-cc3e-4407-ac97-bfe58bc0515d,
  abstract     = {Background: Dysregulation of the immune function in autoimmune diseases could potentially lead to cancer development and there is definite evidence linking some autoimmune mechanisms with cancer. We analyzed systematically the occurrence of histology-specific digestive tract cancers in patients diagnosed with 33 different autoimmune diseases in order to address the question of shared susceptibility. Patients and methods: Standardized incidence ratios (SIRs) were calculated for subsequent digestive tract cancers up to the year 2008 and in patients hospitalized for autoimmune disease after the year 1964. Results: Myasthenia gravis associated with five different cancers with SIRs ranging from 1.35 to 2.78. Pernicious anemia, Crohn disease, ulcerative colitis, systemic lupus erythematosis and psoriasis were also associated with cancers at multiple sites. Rheumatoid arthritis associated with no cancer and the standardized incidence ratio was decreased for colon adenocarcinoma, also in ankylosing spondylitis patients. Conclusions: Increased risks of cancer were observed in patients with several autoimmune diseases. Myasthenia gravis and pernicious anemia were associated with many cancers; this is possibly related to immunosuppressant medication in myasthenia gravis. The decreased risks in colon and rectal adenocarcinomas in rheumatoid arthritis and ankylosing spondylitis suggest underlying inflammatory mechanisms as the risks may have been suppressed by the use of anti-inflammatory medication.},
  author       = {Hemminki, Kari and Liu, Xiangdong and Ji, Jianguang and Sundquist, Jan and Sundquist, Kristina},
  issn         = {1569-8041},
  keyword      = {cancer,digestive tract,autoimmune disease},
  language     = {eng},
  number       = {4},
  pages        = {6--927},
  publisher    = {Oxford University Press},
  series       = {Annals of Oncology},
  title        = {Autoimmune disease and subsequent digestive tract cancer by histology},
  url          = {http://dx.doi.org/10.1093/annonc/mdr333},
  volume       = {23},
  year         = {2012},
}