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Health benefits of oat (Avena sativa) bioactives. Acute and second-meal effects of oat polar lipids and beta-glucans.

Hossain, Mohammad Mukul LU (2024)
Abstract
The global prevalence of lifestyle-related diseases, including obesity, type 2 diabetes and
cardiovascular diseases, continues to increase. Dietary habits are the most significant contributing
modifiable factor in this context. A healthy diet must thus form part of successful preventive strategies to
combat cardiometabolic diseases.
Oats are a sustainable cereal, rich in potential health-promoting bioactive compounds, such as polar
lipids, soluble dietary fibres like beta-glucans and arabinoxylans, antioxidants and avenanthramides.
The present thesis explores the health potential of oat-derived bioactives, focusing on polar lipids and
beta-glucans. Four intervention studies in healthy young adults were conducted... (More)
The global prevalence of lifestyle-related diseases, including obesity, type 2 diabetes and
cardiovascular diseases, continues to increase. Dietary habits are the most significant contributing
modifiable factor in this context. A healthy diet must thus form part of successful preventive strategies to
combat cardiometabolic diseases.
Oats are a sustainable cereal, rich in potential health-promoting bioactive compounds, such as polar
lipids, soluble dietary fibres like beta-glucans and arabinoxylans, antioxidants and avenanthramides.
The present thesis explores the health potential of oat-derived bioactives, focusing on polar lipids and
beta-glucans. Four intervention studies in healthy young adults were conducted to investigate
postprandial metabolic effects of test foods enriched with oat polar lipids (OPL) or beta-glucans.
Postprandial metabolic regulation, e.g. control of glycemia and triglyceridemia, is an important
determinant of the development of cardiometabolic disorders. In this thesis work, the test products were
consumed at breakfast and cardiometabolic disease-related biomarkers were measured in blood
repeatedly, both after breakfast and after a standardised lunch without the bioactive compounds.
The results indicate that OPL (12–15g) included in a breakfast (liquid or solid meal) beneficially impact
blood glucose regulation and circulating triglyceride (TG) concentrations acutely after the breakfast, but
also after the standardised lunch meal. Furthermore, OPL increase the release of satiety-promoting gut
hormones such as GLP-1 and PYY, and reduce the release of the hunger-inducing hormone ghrelin.
Since GLP-1 analogues are effective drugs against type 2 diabetes and obesity, the effects of OPL on
the release of gut hormones become interesting. It was also shown that a commercially available polar
lipid preparation (sunflower lecithin) exerts similar effects to those of OPL.
This work also demonstrates that consumption of beta-glucans from oats improves postprandial
glycaemic responses and subjective appetite sensations acutely after breakfast and after the subsequent
lunch. Also noteworthy was that 2g oat beta-glucans lower the blood glucose peak after a meal, which is
an appreciably lower dose than the 4g dosage stated in the health claim of the European Food Safety
Authority (EFSA). This finding may facilitate the commercial application of beta-glucans in products for
the dietary management of postprandial glycemia.
In conclusion, the thesis shows that consumption of OPL and beta-glucans included in a meal improves
acute and second-meal postprandial glucose tolerance, reduces circulating TG and enhances secretion
of appetite-regulating hormones in healthy young adults. Another remarkable observation is that
relatively low amounts of beta-glucans may reduce blood glucose peaks, in doses below the EFSA’s
recommended ones. The new knowledge generated in this doctoral thesis can contribute to the
development of innovative food products with preventive potential against cardiometabolic diseases. (Less)
Please use this url to cite or link to this publication:
author
supervisor
opponent
  • Doc. Burén, Jonas, Umeå University, Sweden.
organization
publishing date
type
Thesis
publication status
published
subject
pages
97 pages
publisher
Department of Process and Life Science Engineering, Lund University.
defense location
Lecture Hall KC:A, Kemicentrum, Naturvetarvägen 14, Faculty of Engineering LTH, Lund University, Lund
defense date
2024-06-13 09:00:00
ISBN
978-91-8096-043-4
978-91-8096-042-7
language
English
LU publication?
yes
id
257b1292-c3e1-4ab9-84cb-fed5b2c4f496
date added to LUP
2024-05-17 11:36:57
date last changed
2024-05-21 12:24:50
@phdthesis{257b1292-c3e1-4ab9-84cb-fed5b2c4f496,
  abstract     = {{The global prevalence of lifestyle-related diseases, including obesity, type 2 diabetes and<br/>cardiovascular diseases, continues to increase. Dietary habits are the most significant contributing<br/>modifiable factor in this context. A healthy diet must thus form part of successful preventive strategies to<br/>combat cardiometabolic diseases.<br/>Oats are a sustainable cereal, rich in potential health-promoting bioactive compounds, such as polar<br/>lipids, soluble dietary fibres like beta-glucans and arabinoxylans, antioxidants and avenanthramides.<br/>The present thesis explores the health potential of oat-derived bioactives, focusing on polar lipids and<br/>beta-glucans. Four intervention studies in healthy young adults were conducted to investigate<br/>postprandial metabolic effects of test foods enriched with oat polar lipids (OPL) or beta-glucans.<br/>Postprandial metabolic regulation, e.g. control of glycemia and triglyceridemia, is an important<br/>determinant of the development of cardiometabolic disorders. In this thesis work, the test products were<br/>consumed at breakfast and cardiometabolic disease-related biomarkers were measured in blood<br/>repeatedly, both after breakfast and after a standardised lunch without the bioactive compounds.<br/>The results indicate that OPL (12–15g) included in a breakfast (liquid or solid meal) beneficially impact<br/>blood glucose regulation and circulating triglyceride (TG) concentrations acutely after the breakfast, but<br/>also after the standardised lunch meal. Furthermore, OPL increase the release of satiety-promoting gut<br/>hormones such as GLP-1 and PYY, and reduce the release of the hunger-inducing hormone ghrelin.<br/>Since GLP-1 analogues are effective drugs against type 2 diabetes and obesity, the effects of OPL on<br/>the release of gut hormones become interesting. It was also shown that a commercially available polar<br/>lipid preparation (sunflower lecithin) exerts similar effects to those of OPL.<br/>This work also demonstrates that consumption of beta-glucans from oats improves postprandial<br/>glycaemic responses and subjective appetite sensations acutely after breakfast and after the subsequent<br/>lunch. Also noteworthy was that 2g oat beta-glucans lower the blood glucose peak after a meal, which is<br/>an appreciably lower dose than the 4g dosage stated in the health claim of the European Food Safety<br/>Authority (EFSA). This finding may facilitate the commercial application of beta-glucans in products for<br/>the dietary management of postprandial glycemia.<br/>In conclusion, the thesis shows that consumption of OPL and beta-glucans included in a meal improves<br/>acute and second-meal postprandial glucose tolerance, reduces circulating TG and enhances secretion<br/>of appetite-regulating hormones in healthy young adults. Another remarkable observation is that<br/>relatively low amounts of beta-glucans may reduce blood glucose peaks, in doses below the EFSA’s<br/>recommended ones. The new knowledge generated in this doctoral thesis can contribute to the<br/>development of innovative food products with preventive potential against cardiometabolic diseases.}},
  author       = {{Hossain, Mohammad Mukul}},
  isbn         = {{978-91-8096-043-4}},
  language     = {{eng}},
  publisher    = {{Department of Process and Life Science Engineering, Lund University.}},
  school       = {{Lund University}},
  title        = {{Health benefits of oat (Avena sativa) bioactives. Acute and second-meal effects of oat polar lipids and beta-glucans.}},
  url          = {{https://lup.lub.lu.se/search/files/183664432/e-spik_ex_Mukul.pdf}},
  year         = {{2024}},
}