Circulating endogenous sex steroids and risk of differentiated thyroid carcinoma in men and women
(2024) In International Journal of Cancer- Abstract
Thyroid cancer (TC) is substantially more common in women than in men, pointing to a possible role of sex steroid hormones. We investigated the association between circulating sex steroid hormones, sex hormone binding globulin (SHBG) and the risk of differentiated TC in men and women within the European Prospective Investigation into Cancer and nutrition (EPIC) cohort. During follow-up, we identified 333 first primary incident cases of differentiated TC (152 in pre/peri-menopausal women, 111 in post-menopausal women, and 70 in men) and 706 cancer-free controls. Women taking exogenous hormones at blood donation were excluded. Plasma concentrations of testosterone, androstenedione, dehydroepiandrosterone, estradiol, estrone and... (More)
Thyroid cancer (TC) is substantially more common in women than in men, pointing to a possible role of sex steroid hormones. We investigated the association between circulating sex steroid hormones, sex hormone binding globulin (SHBG) and the risk of differentiated TC in men and women within the European Prospective Investigation into Cancer and nutrition (EPIC) cohort. During follow-up, we identified 333 first primary incident cases of differentiated TC (152 in pre/peri-menopausal women, 111 in post-menopausal women, and 70 in men) and 706 cancer-free controls. Women taking exogenous hormones at blood donation were excluded. Plasma concentrations of testosterone, androstenedione, dehydroepiandrosterone, estradiol, estrone and progesterone (in pre-menopausal women only) were performed using liquid chromatography/mass spectrometry method. SHBG concentrations were measured by immunoassay. Odds ratios (ORs) were estimated using conditional logistic regression models adjusted for possible confounders. No significant associations were observed in men and postmenopausal women, while a borderline significant increase in differentiated TC risk was observed with increasing testosterone (adjusted OR T3 vs T1: 1.68, 95% CI: 0.96–2.92, ptrend =.06) and androstenedione concentrations in pre/perimenopausal women (adjusted OR T3 vs T1: 1.78, 95% CI: 0.96–3.30, ptrend =.06, respectively). A borderline decrease in risk was observed for the highest progesterone/estradiol ratio (adjusted OR T3 vs T1: 0.54, 95% CI: 0.28–1.05, ptrend =.07). Overall, our results do not support a major role of circulating sex steroids in the etiology of differentiated TC in post-menopausal women and men but may suggest an involvement of altered sex steroid production in pre-menopausal women.
(Less)
- author
- organization
- publishing date
- 2024
- type
- Contribution to journal
- publication status
- epub
- subject
- keywords
- differentiated thyroid cancer, prospective study, sex steroids
- in
- International Journal of Cancer
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:38357914
- scopus:85185665624
- ISSN
- 0020-7136
- DOI
- 10.1002/ijc.34872
- language
- English
- LU publication?
- yes
- id
- 2582e2fd-3f38-40c6-a782-2dcc7e86b938
- date added to LUP
- 2024-03-18 14:14:08
- date last changed
- 2024-04-26 12:24:19
@article{2582e2fd-3f38-40c6-a782-2dcc7e86b938,
abstract = {{<p>Thyroid cancer (TC) is substantially more common in women than in men, pointing to a possible role of sex steroid hormones. We investigated the association between circulating sex steroid hormones, sex hormone binding globulin (SHBG) and the risk of differentiated TC in men and women within the European Prospective Investigation into Cancer and nutrition (EPIC) cohort. During follow-up, we identified 333 first primary incident cases of differentiated TC (152 in pre/peri-menopausal women, 111 in post-menopausal women, and 70 in men) and 706 cancer-free controls. Women taking exogenous hormones at blood donation were excluded. Plasma concentrations of testosterone, androstenedione, dehydroepiandrosterone, estradiol, estrone and progesterone (in pre-menopausal women only) were performed using liquid chromatography/mass spectrometry method. SHBG concentrations were measured by immunoassay. Odds ratios (ORs) were estimated using conditional logistic regression models adjusted for possible confounders. No significant associations were observed in men and postmenopausal women, while a borderline significant increase in differentiated TC risk was observed with increasing testosterone (adjusted OR T3 vs T1: 1.68, 95% CI: 0.96–2.92, p<sub>trend</sub> =.06) and androstenedione concentrations in pre/perimenopausal women (adjusted OR T3 vs T1: 1.78, 95% CI: 0.96–3.30, p<sub>trend</sub> =.06, respectively). A borderline decrease in risk was observed for the highest progesterone/estradiol ratio (adjusted OR T3 vs T1: 0.54, 95% CI: 0.28–1.05, p<sub>trend</sub> =.07). Overall, our results do not support a major role of circulating sex steroids in the etiology of differentiated TC in post-menopausal women and men but may suggest an involvement of altered sex steroid production in pre-menopausal women.</p>}},
author = {{Rinaldi, Sabina and Dossus, Laure and Keski-Rahkonen, Pekka and Kiss, Agneta and Navionis, Anne Sophie and Biessy, Carine and Travis, Ruth and Weiderpass, Elisabete and Romieu, Isabelle and Eriksen, Anne Kirstine and Tjonneland, Anne and Kvaskoff, Marina and Canonico, Marianne and Truong, Thérèse and Katzke, Verena and Kaaks, Rudolf and Catalano, Alberto and Panico, Salvatore and Masala, Giovanna and Tumino, Rosario and Lukic, Marko and Olsen, Karina Standahl and Zamora-Ros, Raul and Santiuste, Carmen and Aizpurua Atxega, Amaia and Guevara, Marcela and Rodriguez-Barranco, Miguel and Sandstrom, Maria and Hennings, Joakim and Almquist, Martin and Aglago Kouassivi, Elom and Christakoudi, Sofia and Gunter, Marc and Franceschi, Silvia}},
issn = {{0020-7136}},
keywords = {{differentiated thyroid cancer; prospective study; sex steroids}},
language = {{eng}},
publisher = {{John Wiley & Sons Inc.}},
series = {{International Journal of Cancer}},
title = {{Circulating endogenous sex steroids and risk of differentiated thyroid carcinoma in men and women}},
url = {{http://dx.doi.org/10.1002/ijc.34872}},
doi = {{10.1002/ijc.34872}},
year = {{2024}},
}