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Potato fiber protects the small intestinal wall against the toxic influence of acrylamide

Dobrowolski, Piotr; Huet, Pauline LU ; Karlsson, Patrik; Eriksson, Sune; Tomaszewska, Ewa; Gawron, Antoni and Pierzynowski, Stefan G. (2012) In Nutrition 28(4). p.428-435
Abstract
Objective: Acrylamide is a neurotoxic, genotoxic substance present in many commonly consumed food products and has been shown to have carcinogenic effects in rodents. The protective effects (if any) of potato fiber preparations, composed of cell wall material from potatoes, against the toxic influence of dietary acrylamide on the small intestinal wall were investigated. Methods: Male mice of the BALB/c strain were used in the study. Acrylamide was administered to the mice in their drinking water (0.5 mg/kg of body weight per day) and one of two types of potato fiber preparations (heated or raw potato fiber preparation) was added to their feed (2% addition to their feed). Histomorphometry of the small intestinal wall, hemoglobin adducts of... (More)
Objective: Acrylamide is a neurotoxic, genotoxic substance present in many commonly consumed food products and has been shown to have carcinogenic effects in rodents. The protective effects (if any) of potato fiber preparations, composed of cell wall material from potatoes, against the toxic influence of dietary acrylamide on the small intestinal wall were investigated. Methods: Male mice of the BALB/c strain were used in the study. Acrylamide was administered to the mice in their drinking water (0.5 mg/kg of body weight per day) and one of two types of potato fiber preparations (heated or raw potato fiber preparation) was added to their feed (2% addition to their feed). Histomorphometry of the small intestinal wall, hemoglobin adducts of acrylamide, animal weight, and feed and water consumption analyses were performed. Results: Acrylamide altered the morphology and histology of the small intestinal wall, decreasing proliferation, myenteron and submucosal thicknesses, villus length, fractal dimension, crypt depth, crypt number, and the small intestinal absorptive surface. Conversely, apoptosis, hemoglobin adduct levels, intensity of epithelium staining, enterocyte number, villus epithelial thickness, and crypt width and parameters associated with nerve ganglia were increased. The two potato fiber preparations that were used abolished the negative influences of acrylamide on the small intestinal wall and had no influence on the hemoglobin adduct levels of acrylamide. Conclusion: The negative impact of acrylamide on the histologic structure, regeneration, and innervation of the small intestinal wall and the absorptive function of the small intestinal mucosa can be abolished by dietary potato fiber preparations. (C) 2012 Elsevier Inc. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Potato fiber, Dietary fiber, Acrylamide, Small intestine, Histomorphometry, Mouse
in
Nutrition
volume
28
issue
4
pages
428 - 435
publisher
Elsevier
external identifiers
  • wos:000302395800015
  • scopus:84858174612
ISSN
1873-1244
DOI
10.1016/j.nut.2011.10.002
language
English
LU publication?
yes
id
412fde8d-280a-4f09-9c98-622a1185fc52 (old id 2587809)
date added to LUP
2012-05-29 13:21:16
date last changed
2017-07-02 03:19:15
@article{412fde8d-280a-4f09-9c98-622a1185fc52,
  abstract     = {Objective: Acrylamide is a neurotoxic, genotoxic substance present in many commonly consumed food products and has been shown to have carcinogenic effects in rodents. The protective effects (if any) of potato fiber preparations, composed of cell wall material from potatoes, against the toxic influence of dietary acrylamide on the small intestinal wall were investigated. Methods: Male mice of the BALB/c strain were used in the study. Acrylamide was administered to the mice in their drinking water (0.5 mg/kg of body weight per day) and one of two types of potato fiber preparations (heated or raw potato fiber preparation) was added to their feed (2% addition to their feed). Histomorphometry of the small intestinal wall, hemoglobin adducts of acrylamide, animal weight, and feed and water consumption analyses were performed. Results: Acrylamide altered the morphology and histology of the small intestinal wall, decreasing proliferation, myenteron and submucosal thicknesses, villus length, fractal dimension, crypt depth, crypt number, and the small intestinal absorptive surface. Conversely, apoptosis, hemoglobin adduct levels, intensity of epithelium staining, enterocyte number, villus epithelial thickness, and crypt width and parameters associated with nerve ganglia were increased. The two potato fiber preparations that were used abolished the negative influences of acrylamide on the small intestinal wall and had no influence on the hemoglobin adduct levels of acrylamide. Conclusion: The negative impact of acrylamide on the histologic structure, regeneration, and innervation of the small intestinal wall and the absorptive function of the small intestinal mucosa can be abolished by dietary potato fiber preparations. (C) 2012 Elsevier Inc. All rights reserved.},
  author       = {Dobrowolski, Piotr and Huet, Pauline and Karlsson, Patrik and Eriksson, Sune and Tomaszewska, Ewa and Gawron, Antoni and Pierzynowski, Stefan G.},
  issn         = {1873-1244},
  keyword      = {Potato fiber,Dietary fiber,Acrylamide,Small intestine,Histomorphometry,Mouse},
  language     = {eng},
  number       = {4},
  pages        = {428--435},
  publisher    = {Elsevier},
  series       = {Nutrition},
  title        = {Potato fiber protects the small intestinal wall against the toxic influence of acrylamide},
  url          = {http://dx.doi.org/10.1016/j.nut.2011.10.002},
  volume       = {28},
  year         = {2012},
}