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Etiopathogenesis of insulin autoimmunity.

Kanatsuna, Norio LU ; Papadopoulos, George K; Moustakas, Antonis K and Lenmark, Ake (2012) In Anatomy Research International 2012.
Abstract
Autoimmunity against pancreatic islet beta cells is strongly associated with proinsulin, insulin, or both. The insulin autoreactivity is particularly pronounced in children with young age at onset of type 1 diabetes. Possible mechanisms for (pro)insulin autoimmunity may involve beta-cell destruction resulting in proinsulin peptide presentation on HLA-DR-DQ Class II molecules in pancreatic draining lymphnodes. Recent data on proinsulin peptide binding to type 1 diabetes-associated HLA-DQ2 and -DQ8 is reviewed and illustrated by molecular modeling. The importance of the cellular immune reaction involving cytotoxic CD8-positive T cells to kill beta cells through Class I MHC is discussed along with speculations of the possible role of B... (More)
Autoimmunity against pancreatic islet beta cells is strongly associated with proinsulin, insulin, or both. The insulin autoreactivity is particularly pronounced in children with young age at onset of type 1 diabetes. Possible mechanisms for (pro)insulin autoimmunity may involve beta-cell destruction resulting in proinsulin peptide presentation on HLA-DR-DQ Class II molecules in pancreatic draining lymphnodes. Recent data on proinsulin peptide binding to type 1 diabetes-associated HLA-DQ2 and -DQ8 is reviewed and illustrated by molecular modeling. The importance of the cellular immune reaction involving cytotoxic CD8-positive T cells to kill beta cells through Class I MHC is discussed along with speculations of the possible role of B lymphocytes in presenting the proinsulin autoantigen over and over again through insulin-carrying insulin autoantibodies. In contrast to autoantibodies against other islet autoantigens such as GAD65, IA-2, and ZnT8 transporters, it has not been possible yet to standardize the insulin autoantibody test. As islet autoantibodies predict type 1 diabetes, it is imperative to clarify the mechanisms of insulin autoimmunity. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Anatomy Research International
volume
2012
publisher
Hindawi Publishing Corporation
external identifiers
  • pmid:22567309
ISSN
2090-2751
DOI
10.1155/2012/457546
language
English
LU publication?
yes
id
87262d56-d811-454b-b1eb-387180b5555b (old id 2609015)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22567309?dopt=Abstract
date added to LUP
2012-06-03 13:03:57
date last changed
2016-09-20 05:20:07
@article{87262d56-d811-454b-b1eb-387180b5555b,
  abstract     = {Autoimmunity against pancreatic islet beta cells is strongly associated with proinsulin, insulin, or both. The insulin autoreactivity is particularly pronounced in children with young age at onset of type 1 diabetes. Possible mechanisms for (pro)insulin autoimmunity may involve beta-cell destruction resulting in proinsulin peptide presentation on HLA-DR-DQ Class II molecules in pancreatic draining lymphnodes. Recent data on proinsulin peptide binding to type 1 diabetes-associated HLA-DQ2 and -DQ8 is reviewed and illustrated by molecular modeling. The importance of the cellular immune reaction involving cytotoxic CD8-positive T cells to kill beta cells through Class I MHC is discussed along with speculations of the possible role of B lymphocytes in presenting the proinsulin autoantigen over and over again through insulin-carrying insulin autoantibodies. In contrast to autoantibodies against other islet autoantigens such as GAD65, IA-2, and ZnT8 transporters, it has not been possible yet to standardize the insulin autoantibody test. As islet autoantibodies predict type 1 diabetes, it is imperative to clarify the mechanisms of insulin autoimmunity.},
  articleno    = {457546},
  author       = {Kanatsuna, Norio and Papadopoulos, George K and Moustakas, Antonis K and Lenmark, Ake},
  issn         = {2090-2751},
  language     = {eng},
  publisher    = {Hindawi Publishing Corporation},
  series       = {Anatomy Research International},
  title        = {Etiopathogenesis of insulin autoimmunity.},
  url          = {http://dx.doi.org/10.1155/2012/457546},
  volume       = {2012},
  year         = {2012},
}