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Very high correlations between fresh weight and lipid-adjusted PCB-153 serum concentrations: Irrespective of fasting status, age, body mass index, gender, or exposure distributions.

Rylander, Lars LU ; Björkdahl, Carl-Magnus; Axmon, Anna LU ; Giwercman, Aleksander LU ; Jönsson, Bo A LU ; Lindh, Christian LU and Rignell-Hydbom, Anna LU (2012) In Chemosphere 88(7). p.828-831
Abstract
BACKGROUND AND AIM:

Persistent organochlorine pollutants (POPs) have in epidemiological studies been associated with health hazards. The exposure window might be crucial and it is, accordingly, important to analyze exposure concentrations in samples collected at the window of interest. This makes the use of stored blood samples extremely interesting. However, small blood volumes from stored samples in biobanks means that the researchers in epidemiological studies most often have to select a limited number of biomarkers representing the POP exposure and abstain from analyses of lipid concentrations. This raises the question of the necessity of lipid adjustment. The aim of the present study was to evaluate the correlation between... (More)
BACKGROUND AND AIM:

Persistent organochlorine pollutants (POPs) have in epidemiological studies been associated with health hazards. The exposure window might be crucial and it is, accordingly, important to analyze exposure concentrations in samples collected at the window of interest. This makes the use of stored blood samples extremely interesting. However, small blood volumes from stored samples in biobanks means that the researchers in epidemiological studies most often have to select a limited number of biomarkers representing the POP exposure and abstain from analyses of lipid concentrations. This raises the question of the necessity of lipid adjustment. The aim of the present study was to evaluate the correlation between fresh weight and lipid adjusted concentrations.



METHODS:

We included data from studies were we have used the PCB congener 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153) as a biomarker for POP exposure and where fresh weight as well as lipid adjusted PCB-153 concentrations are known (n=1628). The variety of the cohort members in the different studies gave us the possibility to better understand how well these measures correlate.



RESULTS:

When all individuals were included in the analyses a correlation coefficient of 0.95 between fresh weight and lipid adjusted serum concentrations was obtained. Restricting the analyses to specific subgroups (based on gender, fasting status, age and BMI) gave correlation coefficients between 0.85 and 0.97.



CONCLUSIONS:

This study does strongly support the use of samples from biobanks in epidemiological studies for analyzing PCBs, at least regarding PCB-153, even though it is not possible to lipid adjust the results. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Chemosphere
volume
88
issue
7
pages
828 - 831
publisher
Elsevier
external identifiers
  • wos:000305600500010
  • pmid:22546635
  • scopus:84861709267
ISSN
1879-1298
DOI
10.1016/j.chemosphere.2012.03.089
language
English
LU publication?
yes
id
756ee443-f8bc-4e43-9e46-489af686fe2b (old id 2609310)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22546635?dopt=Abstract
date added to LUP
2012-06-02 15:34:46
date last changed
2017-02-26 04:24:01
@article{756ee443-f8bc-4e43-9e46-489af686fe2b,
  abstract     = {BACKGROUND AND AIM: <br/><br>
Persistent organochlorine pollutants (POPs) have in epidemiological studies been associated with health hazards. The exposure window might be crucial and it is, accordingly, important to analyze exposure concentrations in samples collected at the window of interest. This makes the use of stored blood samples extremely interesting. However, small blood volumes from stored samples in biobanks means that the researchers in epidemiological studies most often have to select a limited number of biomarkers representing the POP exposure and abstain from analyses of lipid concentrations. This raises the question of the necessity of lipid adjustment. The aim of the present study was to evaluate the correlation between fresh weight and lipid adjusted concentrations. <br/><br>
<br/><br>
METHODS: <br/><br>
We included data from studies were we have used the PCB congener 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153) as a biomarker for POP exposure and where fresh weight as well as lipid adjusted PCB-153 concentrations are known (n=1628). The variety of the cohort members in the different studies gave us the possibility to better understand how well these measures correlate. <br/><br>
<br/><br>
RESULTS: <br/><br>
When all individuals were included in the analyses a correlation coefficient of 0.95 between fresh weight and lipid adjusted serum concentrations was obtained. Restricting the analyses to specific subgroups (based on gender, fasting status, age and BMI) gave correlation coefficients between 0.85 and 0.97. <br/><br>
<br/><br>
CONCLUSIONS: <br/><br>
This study does strongly support the use of samples from biobanks in epidemiological studies for analyzing PCBs, at least regarding PCB-153, even though it is not possible to lipid adjust the results.},
  author       = {Rylander, Lars and Björkdahl, Carl-Magnus and Axmon, Anna and Giwercman, Aleksander and Jönsson, Bo A and Lindh, Christian and Rignell-Hydbom, Anna},
  issn         = {1879-1298},
  language     = {eng},
  number       = {7},
  pages        = {828--831},
  publisher    = {Elsevier},
  series       = {Chemosphere},
  title        = {Very high correlations between fresh weight and lipid-adjusted PCB-153 serum concentrations: Irrespective of fasting status, age, body mass index, gender, or exposure distributions.},
  url          = {http://dx.doi.org/10.1016/j.chemosphere.2012.03.089},
  volume       = {88},
  year         = {2012},
}