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Invasive cutaneous malignant melanoma in Sweden, 1990-1999 - A prospective, population-based study of survival and prognostic factors

Lindholm, C; Andersson, R; Dufmats, M; Hansson, J; Ingvar, Christian LU ; Möller, Torgil LU ; Sjodin, H and Stierner, U (2004) In Cancer 101(9). p.2067-2078
Abstract
BACKGROUND. The objective of the current study was to compile prospective, population-based data on cutaneous invasive melanomas in Sweden during the period from 1990 to 1999, to describe and analyze survival data and prognostic factors, and to make comparisons with previously published Swedish and international data. METHODS. Twelve thousand five hundred thirty-three patients, which included 97% of all registered melanomas in Sweden, were included and described. Among these, 9515 patients with clinical Stage I and II melanoma were included in an analysis of survival and in a univariate analysis, and 6191 patients were included in a multivariate analysis of prognostic factors. RESULTS. There was no significant change in melanoma incidence... (More)
BACKGROUND. The objective of the current study was to compile prospective, population-based data on cutaneous invasive melanomas in Sweden during the period from 1990 to 1999, to describe and analyze survival data and prognostic factors, and to make comparisons with previously published Swedish and international data. METHODS. Twelve thousand five hundred thirty-three patients, which included 97% of all registered melanomas in Sweden, were included and described. Among these, 9515 patients with clinical Stage I and II melanoma were included in an analysis of survival and in a univariate analysis, and 6191 patients were included in a multivariate analysis of prognostic factors. RESULTS. There was no significant change in melanoma incidence during 1990-1999. Favorable prognostic factors were found, especially in younger and female patients, resulting in a relative 5-year survival rate of 91.5%. In the multivariate analysis, significant factors that had a negative effect on survival were Clark level of invasion, Breslow thickness, ulceration, older patient age, trunk location, greatest tumor dimension, nodular histogenetic type, and male gender. CONCLUSIONS. During the period from 1990 to 1999, the 5-year survival of patients with malignant melanoma in Sweden was better compared with the previously reported rates in published, population-based studies from Sweden, probably as a result of better secondary prevention due to better knowledge and awareness by both patients and the medical profession. The more favorable prognostic factors and the change in melanoma location found in younger patients, compared with earlier reports, may reflect changes in clothing as well as tanning habits; however, a decrease also was found in Clark Level II and thin melanomas for the same patient group. The authors concluded that further improvements can be achieved with better access to health care and with the use of early melanoma detection campaigns. (C) 2004 American Cancer Society. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
prospective, prognostic factors, cutaneous malignant melanoma, survival, population-based, incidence
in
Cancer
volume
101
issue
9
pages
2067 - 2078
publisher
John Wiley & Sons
external identifiers
  • pmid:15372475
  • wos:000224627100019
  • scopus:7044272563
ISSN
1097-0142
DOI
10.1002/cncr.20602
language
English
LU publication?
yes
id
d3c26db8-9058-4e6f-ae7f-677269bfd85b (old id 262533)
date added to LUP
2007-10-24 19:35:48
date last changed
2017-11-12 03:31:36
@article{d3c26db8-9058-4e6f-ae7f-677269bfd85b,
  abstract     = {BACKGROUND. The objective of the current study was to compile prospective, population-based data on cutaneous invasive melanomas in Sweden during the period from 1990 to 1999, to describe and analyze survival data and prognostic factors, and to make comparisons with previously published Swedish and international data. METHODS. Twelve thousand five hundred thirty-three patients, which included 97% of all registered melanomas in Sweden, were included and described. Among these, 9515 patients with clinical Stage I and II melanoma were included in an analysis of survival and in a univariate analysis, and 6191 patients were included in a multivariate analysis of prognostic factors. RESULTS. There was no significant change in melanoma incidence during 1990-1999. Favorable prognostic factors were found, especially in younger and female patients, resulting in a relative 5-year survival rate of 91.5%. In the multivariate analysis, significant factors that had a negative effect on survival were Clark level of invasion, Breslow thickness, ulceration, older patient age, trunk location, greatest tumor dimension, nodular histogenetic type, and male gender. CONCLUSIONS. During the period from 1990 to 1999, the 5-year survival of patients with malignant melanoma in Sweden was better compared with the previously reported rates in published, population-based studies from Sweden, probably as a result of better secondary prevention due to better knowledge and awareness by both patients and the medical profession. The more favorable prognostic factors and the change in melanoma location found in younger patients, compared with earlier reports, may reflect changes in clothing as well as tanning habits; however, a decrease also was found in Clark Level II and thin melanomas for the same patient group. The authors concluded that further improvements can be achieved with better access to health care and with the use of early melanoma detection campaigns. (C) 2004 American Cancer Society.},
  author       = {Lindholm, C and Andersson, R and Dufmats, M and Hansson, J and Ingvar, Christian and Möller, Torgil and Sjodin, H and Stierner, U},
  issn         = {1097-0142},
  keyword      = {prospective,prognostic factors,cutaneous malignant melanoma,survival,population-based,incidence},
  language     = {eng},
  number       = {9},
  pages        = {2067--2078},
  publisher    = {John Wiley & Sons},
  series       = {Cancer},
  title        = {Invasive cutaneous malignant melanoma in Sweden, 1990-1999 - A prospective, population-based study of survival and prognostic factors},
  url          = {http://dx.doi.org/10.1002/cncr.20602},
  volume       = {101},
  year         = {2004},
}