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Neuropeptide Y and seizures: effects of exogenously applied ligands

Woldbye, DPD and Kokaia, Merab LU (2004) In Neuropeptides 38(4). p.253-260
Abstract
The endogenous NPY system in the brain is centrally involved in seizure regulation. The present paper reviews the evidence that exogenously applied NPY receptor ligands can inhibit epileptic seizures in various rodent in vitro and in vivo models. Agonists at Y2 and/or Y5 receptors and antagonists at Y1 receptors appear to inhibit seizures, depending on the seizure model studied. Although progress has been made, further studies are needed using transgenic animals as well as novel selective agonists and antagonists to firmly identify the NPY receptors mediating antiepileptic effects. This may lead to the development of future antiepileptic drug treatments targeting the NPY system, (C) 2004 Elsevier Ltd. All rights reserved.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
rat, seizure, NPY, epilepsy, mouse
in
Neuropeptides
volume
38
issue
4
pages
253 - 260
publisher
Elsevier
external identifiers
  • pmid:15337377
  • wos:000224172700012
  • scopus:4344616253
ISSN
1532-2785
DOI
10.1016/j.npep.2004.07.001
language
English
LU publication?
yes
id
0b2d5d11-5b7b-4c0b-a278-4846f993b332 (old id 265268)
date added to LUP
2007-11-05 15:50:15
date last changed
2017-07-02 04:24:46
@article{0b2d5d11-5b7b-4c0b-a278-4846f993b332,
  abstract     = {The endogenous NPY system in the brain is centrally involved in seizure regulation. The present paper reviews the evidence that exogenously applied NPY receptor ligands can inhibit epileptic seizures in various rodent in vitro and in vivo models. Agonists at Y2 and/or Y5 receptors and antagonists at Y1 receptors appear to inhibit seizures, depending on the seizure model studied. Although progress has been made, further studies are needed using transgenic animals as well as novel selective agonists and antagonists to firmly identify the NPY receptors mediating antiepileptic effects. This may lead to the development of future antiepileptic drug treatments targeting the NPY system, (C) 2004 Elsevier Ltd. All rights reserved.},
  author       = {Woldbye, DPD and Kokaia, Merab},
  issn         = {1532-2785},
  keyword      = {rat,seizure,NPY,epilepsy,mouse},
  language     = {eng},
  number       = {4},
  pages        = {253--260},
  publisher    = {Elsevier},
  series       = {Neuropeptides},
  title        = {Neuropeptide Y and seizures: effects of exogenously applied ligands},
  url          = {http://dx.doi.org/10.1016/j.npep.2004.07.001},
  volume       = {38},
  year         = {2004},
}