Autonomic cardiovascular responses to tilting in patients with alzheimer's disease and in healthy elderly women
(1992) In Age and Ageing 21(4). p.301-307- Abstract
The cardiovascular responses to tilting and breathing were studied in 24 patients with late-onset Alzheimer's disease (AD) and 54 healthy control women aged between 75 and 96 years in order to study the parasympathetic and sympathetic heart-rate control. The cardiovascular response to tilting and breathing showed no age-associated decrease in the healthy control women. During rest, the AD patients had lower mean systolic and diastolic blood pressure but the same heart rate as the control patients. After tilting, the AD patients had a greater increase in heart rate, and the mean systolic blood pressure fell to 126 mmHg compared with 160 mmHg in the control women (p<0.001). After the initial acceleration, the following deceleration of... (More)
The cardiovascular responses to tilting and breathing were studied in 24 patients with late-onset Alzheimer's disease (AD) and 54 healthy control women aged between 75 and 96 years in order to study the parasympathetic and sympathetic heart-rate control. The cardiovascular response to tilting and breathing showed no age-associated decrease in the healthy control women. During rest, the AD patients had lower mean systolic and diastolic blood pressure but the same heart rate as the control patients. After tilting, the AD patients had a greater increase in heart rate, and the mean systolic blood pressure fell to 126 mmHg compared with 160 mmHg in the control women (p<0.001). After the initial acceleration, the following deceleration of the heart rate, an expression of parasympathetic nervous activity, was lower in the AD patients (p <0.001). The deep-breathing test showed no significant difference between the two groups, but the changes of acceleration and brake indices could indicate a dysfunction of the autonomic nervous system since the AD patients were not recumbent.
(Less)
- author
- Elmståhl, Sölve LU ; Petersson, Marie ; Lilja, Bo ; Samuelsson, Sven Mårten ; Rosén, Ingmar LU and Bjunö, Lillemor
- organization
- publishing date
- 1992-07-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Age and Ageing
- volume
- 21
- issue
- 4
- pages
- 7 pages
- publisher
- Oxford University Press
- external identifiers
-
- scopus:0026634738
- pmid:1514460
- ISSN
- 0002-0729
- DOI
- 10.1093/ageing/21.4.301
- language
- English
- LU publication?
- yes
- id
- 26be9326-da5d-494b-a74f-6dda7edb5708
- date added to LUP
- 2019-06-19 11:56:18
- date last changed
- 2024-01-01 11:30:00
@article{26be9326-da5d-494b-a74f-6dda7edb5708,
abstract = {{<p>The cardiovascular responses to tilting and breathing were studied in 24 patients with late-onset Alzheimer's disease (AD) and 54 healthy control women aged between 75 and 96 years in order to study the parasympathetic and sympathetic heart-rate control. The cardiovascular response to tilting and breathing showed no age-associated decrease in the healthy control women. During rest, the AD patients had lower mean systolic and diastolic blood pressure but the same heart rate as the control patients. After tilting, the AD patients had a greater increase in heart rate, and the mean systolic blood pressure fell to 126 mmHg compared with 160 mmHg in the control women (p<0.001). After the initial acceleration, the following deceleration of the heart rate, an expression of parasympathetic nervous activity, was lower in the AD patients (p <0.001). The deep-breathing test showed no significant difference between the two groups, but the changes of acceleration and brake indices could indicate a dysfunction of the autonomic nervous system since the AD patients were not recumbent.</p>}},
author = {{Elmståhl, Sölve and Petersson, Marie and Lilja, Bo and Samuelsson, Sven Mårten and Rosén, Ingmar and Bjunö, Lillemor}},
issn = {{0002-0729}},
language = {{eng}},
month = {{07}},
number = {{4}},
pages = {{301--307}},
publisher = {{Oxford University Press}},
series = {{Age and Ageing}},
title = {{Autonomic cardiovascular responses to tilting in patients with alzheimer's disease and in healthy elderly women}},
url = {{http://dx.doi.org/10.1093/ageing/21.4.301}},
doi = {{10.1093/ageing/21.4.301}},
volume = {{21}},
year = {{1992}},
}