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Autonomic cardiovascular responses to tilting in patients with alzheimer's disease and in healthy elderly women

Elmståhl, Sölve LU ; Petersson, Marie ; Lilja, Bo ; Samuelsson, Sven Mårten ; Rosén, Ingmar LU and Bjunö, Lillemor (1992) In Age and Ageing 21(4). p.301-307
Abstract

The cardiovascular responses to tilting and breathing were studied in 24 patients with late-onset Alzheimer's disease (AD) and 54 healthy control women aged between 75 and 96 years in order to study the parasympathetic and sympathetic heart-rate control. The cardiovascular response to tilting and breathing showed no age-associated decrease in the healthy control women. During rest, the AD patients had lower mean systolic and diastolic blood pressure but the same heart rate as the control patients. After tilting, the AD patients had a greater increase in heart rate, and the mean systolic blood pressure fell to 126 mmHg compared with 160 mmHg in the control women (p<0.001). After the initial acceleration, the following deceleration of... (More)

The cardiovascular responses to tilting and breathing were studied in 24 patients with late-onset Alzheimer's disease (AD) and 54 healthy control women aged between 75 and 96 years in order to study the parasympathetic and sympathetic heart-rate control. The cardiovascular response to tilting and breathing showed no age-associated decrease in the healthy control women. During rest, the AD patients had lower mean systolic and diastolic blood pressure but the same heart rate as the control patients. After tilting, the AD patients had a greater increase in heart rate, and the mean systolic blood pressure fell to 126 mmHg compared with 160 mmHg in the control women (p<0.001). After the initial acceleration, the following deceleration of the heart rate, an expression of parasympathetic nervous activity, was lower in the AD patients (p <0.001). The deep-breathing test showed no significant difference between the two groups, but the changes of acceleration and brake indices could indicate a dysfunction of the autonomic nervous system since the AD patients were not recumbent.

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type
Contribution to journal
publication status
published
subject
in
Age and Ageing
volume
21
issue
4
pages
7 pages
publisher
Oxford University Press
external identifiers
  • scopus:0026634738
  • pmid:1514460
ISSN
0002-0729
DOI
10.1093/ageing/21.4.301
language
English
LU publication?
yes
id
26be9326-da5d-494b-a74f-6dda7edb5708
date added to LUP
2019-06-19 11:56:18
date last changed
2021-01-03 05:31:45
@article{26be9326-da5d-494b-a74f-6dda7edb5708,
  abstract     = {<p>The cardiovascular responses to tilting and breathing were studied in 24 patients with late-onset Alzheimer's disease (AD) and 54 healthy control women aged between 75 and 96 years in order to study the parasympathetic and sympathetic heart-rate control. The cardiovascular response to tilting and breathing showed no age-associated decrease in the healthy control women. During rest, the AD patients had lower mean systolic and diastolic blood pressure but the same heart rate as the control patients. After tilting, the AD patients had a greater increase in heart rate, and the mean systolic blood pressure fell to 126 mmHg compared with 160 mmHg in the control women (p&lt;0.001). After the initial acceleration, the following deceleration of the heart rate, an expression of parasympathetic nervous activity, was lower in the AD patients (p &lt;0.001). The deep-breathing test showed no significant difference between the two groups, but the changes of acceleration and brake indices could indicate a dysfunction of the autonomic nervous system since the AD patients were not recumbent.</p>},
  author       = {Elmståhl, Sölve and Petersson, Marie and Lilja, Bo and Samuelsson, Sven Mårten and Rosén, Ingmar and Bjunö, Lillemor},
  issn         = {0002-0729},
  language     = {eng},
  month        = {07},
  number       = {4},
  pages        = {301--307},
  publisher    = {Oxford University Press},
  series       = {Age and Ageing},
  title        = {Autonomic cardiovascular responses to tilting in patients with alzheimer's disease and in healthy elderly women},
  url          = {http://dx.doi.org/10.1093/ageing/21.4.301},
  doi          = {10.1093/ageing/21.4.301},
  volume       = {21},
  year         = {1992},
}