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Mediterranean diet and colorectal cancer risk: results from a European cohort

Bamia, Christina; Lagiou, Pagona; Buckland, Genevieve; Grioni, Sara; Agnoli, Claudia; Taylor, Aliki J.; Dahm, Christina C.; Overvad, Kim; Olsen, Anja and Tjonneland, Anne, et al. (2013) In European Journal of Epidemiology 28(4). p.317-328
Abstract
The authors investigated the association of adherence to Mediterranean diet with colorectal cancer (CRC) risk in the European Prospective Investigation into Cancer and nutrition study. Adherence to Mediterranean diet was expressed through two 10-unit scales, the Modified Mediterranean diet score (MMDS) and the Centre-Specific MMDS (CSMMDS). Both scales share the same dietary components but differ in the cut-off values that were used for these components in the construction of the scales. Adjusted hazard ratios (HR) for the associations of these scales with CRC incidence were estimated. After 5,296,617 person-years of follow-up, 4,355 incident CRC cases were identified. A decreased risk of CRC, of 8 and 11 % was estimated when comparing the... (More)
The authors investigated the association of adherence to Mediterranean diet with colorectal cancer (CRC) risk in the European Prospective Investigation into Cancer and nutrition study. Adherence to Mediterranean diet was expressed through two 10-unit scales, the Modified Mediterranean diet score (MMDS) and the Centre-Specific MMDS (CSMMDS). Both scales share the same dietary components but differ in the cut-off values that were used for these components in the construction of the scales. Adjusted hazard ratios (HR) for the associations of these scales with CRC incidence were estimated. After 5,296,617 person-years of follow-up, 4,355 incident CRC cases were identified. A decreased risk of CRC, of 8 and 11 % was estimated when comparing the highest (scores 6-9) with the lowest (scores 0-3) adherence to CSMMDS and MMDS respectively. For MMDS the HR was 0.89 (95 % confidence interval (CI): 0.80, 0.99). A 2-unit increment in either Mediterranean scale was associated with a borderline statistically significant 3 to 4 % reduction in CRC risk (HR for MMDS: 0.96; 95 % CI: 0.92, 1.00). These associations were somewhat more evident, among women, were mainly manifested for colon cancer risk and their magnitude was not altered when alcohol was excluded from MMDS. These findings suggest that following a Mediterranean diet may have a modest beneficial effect on CRC risk. (Less)
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Contribution to journal
publication status
published
subject
keywords
Mediterranean diet, Colorectal cancer, Cohort study
in
European Journal of Epidemiology
volume
28
issue
4
pages
317 - 328
publisher
Springer
external identifiers
  • wos:000318896000005
  • scopus:84878019908
ISSN
1573-7284
DOI
10.1007/s10654-013-9795-x
language
English
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yes
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26beb7f9-ff4e-4da1-a809-0152168a3ba2 (old id 3935587)
date added to LUP
2013-07-15 10:31:33
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2019-06-09 03:09:57
@article{26beb7f9-ff4e-4da1-a809-0152168a3ba2,
  abstract     = {The authors investigated the association of adherence to Mediterranean diet with colorectal cancer (CRC) risk in the European Prospective Investigation into Cancer and nutrition study. Adherence to Mediterranean diet was expressed through two 10-unit scales, the Modified Mediterranean diet score (MMDS) and the Centre-Specific MMDS (CSMMDS). Both scales share the same dietary components but differ in the cut-off values that were used for these components in the construction of the scales. Adjusted hazard ratios (HR) for the associations of these scales with CRC incidence were estimated. After 5,296,617 person-years of follow-up, 4,355 incident CRC cases were identified. A decreased risk of CRC, of 8 and 11 % was estimated when comparing the highest (scores 6-9) with the lowest (scores 0-3) adherence to CSMMDS and MMDS respectively. For MMDS the HR was 0.89 (95 % confidence interval (CI): 0.80, 0.99). A 2-unit increment in either Mediterranean scale was associated with a borderline statistically significant 3 to 4 % reduction in CRC risk (HR for MMDS: 0.96; 95 % CI: 0.92, 1.00). These associations were somewhat more evident, among women, were mainly manifested for colon cancer risk and their magnitude was not altered when alcohol was excluded from MMDS. These findings suggest that following a Mediterranean diet may have a modest beneficial effect on CRC risk.},
  author       = {Bamia, Christina and Lagiou, Pagona and Buckland, Genevieve and Grioni, Sara and Agnoli, Claudia and Taylor, Aliki J. and Dahm, Christina C. and Overvad, Kim and Olsen, Anja and Tjonneland, Anne and Cottet, Vanessa and Boutron-Ruault, Marie-Christine and Morois, Sophie and Grote, Verena and Teucher, Birgit and Boeing, Heiner and Buijsse, Brian and Trichopoulos, Dimitrios and Adarakis, George and Tumino, Rosario and Naccarati, Alessio and Panico, Salvatore and Palli, Domenico and Bueno-de-Mesquita, H. Bas and van Duijnhoven, Fraenzel J. B. and Peeters, Petra H. M. and Engeset, Dagrun and Skeie, Guri and Lund, Eiliv and Sanchez, Maria-Jose and Barricarte, Aurelio and Huerta, Jose-Maria and Ramon Quiros, J. and Dorronsoro, Miren and Ljuslinder, Ingrid and Palmqvist, Richard and Drake, Isabel and Key, Timothy J. and Khaw, Kay-Tee and Wareham, Nick and Romieu, Isabelle and Fedirko, Veronika and Jenab, Mazda and Romaguera, Dora and Norat, Teresa and Trichopoulou, Antonia},
  issn         = {1573-7284},
  keyword      = {Mediterranean diet,Colorectal cancer,Cohort study},
  language     = {eng},
  number       = {4},
  pages        = {317--328},
  publisher    = {Springer},
  series       = {European Journal of Epidemiology},
  title        = {Mediterranean diet and colorectal cancer risk: results from a European cohort},
  url          = {http://dx.doi.org/10.1007/s10654-013-9795-x},
  volume       = {28},
  year         = {2013},
}