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Stem cell therapy for human neurodegenerative disorders-how to make it work

Lindvall, Olle LU ; Kokaia, Zaal LU and Martinez-Serrano, A (2004) In Nature Reviews Neuroscience 10(Suppl.). p.42-50
Abstract
Recent progress shows that neurons suitable for transplantation can be generated from stem cells in culture, and that the adult brain produces new neurons from its own stem cells in response to injury. These findings raise hope for the development of stem cell therapies in human neurodegenerative disorders. Before clinical trials are initiated, we need to know much more about how to control stem cell proliferation and differentiation into specific phenotypes, induce their integration into existing neural and synaptic circuits, and optimize functional recovery in animal models closely resembling the human disease.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nature Reviews Neuroscience
volume
10
issue
Suppl.
pages
42 - 50
publisher
Nature Publishing Group
external identifiers
  • wos:000223202200007
  • wos:000223202100007
  • scopus:3142521479
ISSN
1471-003X
DOI
10.1038/nm1064
language
English
LU publication?
yes
id
b0f56740-b745-49a9-9a55-c002bc4a7f67 (old id 270728)
date added to LUP
2007-10-24 19:56:38
date last changed
2017-11-19 04:15:10
@article{b0f56740-b745-49a9-9a55-c002bc4a7f67,
  abstract     = {Recent progress shows that neurons suitable for transplantation can be generated from stem cells in culture, and that the adult brain produces new neurons from its own stem cells in response to injury. These findings raise hope for the development of stem cell therapies in human neurodegenerative disorders. Before clinical trials are initiated, we need to know much more about how to control stem cell proliferation and differentiation into specific phenotypes, induce their integration into existing neural and synaptic circuits, and optimize functional recovery in animal models closely resembling the human disease.},
  author       = {Lindvall, Olle and Kokaia, Zaal and Martinez-Serrano, A},
  issn         = {1471-003X},
  language     = {eng},
  number       = {Suppl.},
  pages        = {42--50},
  publisher    = {Nature Publishing Group},
  series       = {Nature Reviews Neuroscience},
  title        = {Stem cell therapy for human neurodegenerative disorders-how to make it work},
  url          = {http://dx.doi.org/10.1038/nm1064},
  volume       = {10},
  year         = {2004},
}