Advanced

Epithelial–mesenchymal transition, a spectrum of states : Role in lung development, homeostasis, and disease

Jolly, Mohit Kumar ; Ward, Chris ; Eapen, Mathew Suji ; Myers, Stephen ; Hallgren, Oskar LU ; Levine, Herbert and Sohal, Sukhwinder Singh (2018) In Developmental Dynamics 247(3). p.346-358
Abstract

Epithelial–mesenchymal transition (EMT) plays key roles during lung development and many lung diseases such as chronic obstructive pulmonary disease (COPD), lung cancer, and pulmonary fibrosis. Here, integrating morphological observations with underlying molecular mechanisms, we highlight the functional role of EMT in lung development and injury repair, and discuss how it can contribute to pathogenesis of chronic lung disease. We discuss the evidence of manifestation of EMT and its potential driving role in COPD, idiopathic pulmonary fibrosis (IPF), bronchiolitis obliterans syndrome (BOS), and lung cancer, while noting that all cells need not display a full EMT in any of these contexts, i.e., often cells co-express epithelial and... (More)

Epithelial–mesenchymal transition (EMT) plays key roles during lung development and many lung diseases such as chronic obstructive pulmonary disease (COPD), lung cancer, and pulmonary fibrosis. Here, integrating morphological observations with underlying molecular mechanisms, we highlight the functional role of EMT in lung development and injury repair, and discuss how it can contribute to pathogenesis of chronic lung disease. We discuss the evidence of manifestation of EMT and its potential driving role in COPD, idiopathic pulmonary fibrosis (IPF), bronchiolitis obliterans syndrome (BOS), and lung cancer, while noting that all cells need not display a full EMT in any of these contexts, i.e., often cells co-express epithelial and mesenchymal markers but do not fully convert to extracellular matrix (ECM) -producing fibroblasts. Finally, we discuss recent therapeutic attempts to restrict EMT in chronic lung disease. Developmental Dynamics 247:346–358, 2018.

(Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
chronic pulmonary obstructive disease (COPD), epithelial–mesenchymal transition (EMT), hybrid epithelial/mesenchymal, idiopathic pulmonary fibrosis (IPF), lung cancer
in
Developmental Dynamics
volume
247
issue
3
pages
346 - 358
publisher
John Wiley and Sons Inc.
external identifiers
  • pmid:28646553
  • scopus:85028985989
ISSN
1058-8388
DOI
10.1002/dvdy.24541
language
English
LU publication?
yes
id
27544c38-ff51-4b63-b42b-91f8a3047a3a
date added to LUP
2019-05-24 09:25:23
date last changed
2020-07-08 04:53:21
@article{27544c38-ff51-4b63-b42b-91f8a3047a3a,
  abstract     = {<p>Epithelial–mesenchymal transition (EMT) plays key roles during lung development and many lung diseases such as chronic obstructive pulmonary disease (COPD), lung cancer, and pulmonary fibrosis. Here, integrating morphological observations with underlying molecular mechanisms, we highlight the functional role of EMT in lung development and injury repair, and discuss how it can contribute to pathogenesis of chronic lung disease. We discuss the evidence of manifestation of EMT and its potential driving role in COPD, idiopathic pulmonary fibrosis (IPF), bronchiolitis obliterans syndrome (BOS), and lung cancer, while noting that all cells need not display a full EMT in any of these contexts, i.e., often cells co-express epithelial and mesenchymal markers but do not fully convert to extracellular matrix (ECM) -producing fibroblasts. Finally, we discuss recent therapeutic attempts to restrict EMT in chronic lung disease. Developmental Dynamics 247:346–358, 2018.</p>},
  author       = {Jolly, Mohit Kumar and Ward, Chris and Eapen, Mathew Suji and Myers, Stephen and Hallgren, Oskar and Levine, Herbert and Sohal, Sukhwinder Singh},
  issn         = {1058-8388},
  language     = {eng},
  month        = {03},
  number       = {3},
  pages        = {346--358},
  publisher    = {John Wiley and Sons Inc.},
  series       = {Developmental Dynamics},
  title        = {Epithelial–mesenchymal transition, a spectrum of states : Role in lung development, homeostasis, and disease},
  url          = {http://dx.doi.org/10.1002/dvdy.24541},
  doi          = {10.1002/dvdy.24541},
  volume       = {247},
  year         = {2018},
}