Effects on brain edema of crystalloid and albumin fluid resuscitation after brain trauma and hemorrhage in the rat.
(2010) In Anesthesiology 112(5). p.1194-1203- Abstract
- BACKGROUND: It has been hypothesized that resuscitation with crystalloids after brain trauma increases brain edema compared with colloids, but previous studies on the subject have been inconclusive. To test this hypothesis, the authors compared groups resuscitated with either colloid or crystalloid. METHODS: After fluid percussion injury, rats were subjected to a controlled hemorrhage of 20 ml/kg and were randomized to 5% albumin at 20 ml/kg (A20), isotonic Ringer's acetate at 50 ml/kg (C50), or 90 ml/kg (C90). After 3 or 24 h, water content in the injured cortex was determined using a wet/dry weight method. Blood volume was calculated from plasma volume, measured by 125I-albumin dilution, and hematocrit. Oncotic pressure and osmolality... (More)
- BACKGROUND: It has been hypothesized that resuscitation with crystalloids after brain trauma increases brain edema compared with colloids, but previous studies on the subject have been inconclusive. To test this hypothesis, the authors compared groups resuscitated with either colloid or crystalloid. METHODS: After fluid percussion injury, rats were subjected to a controlled hemorrhage of 20 ml/kg and were randomized to 5% albumin at 20 ml/kg (A20), isotonic Ringer's acetate at 50 ml/kg (C50), or 90 ml/kg (C90). After 3 or 24 h, water content in the injured cortex was determined using a wet/dry weight method. Blood volume was calculated from plasma volume, measured by 125I-albumin dilution, and hematocrit. Oncotic pressure and osmolality were measured with osmometers. RESULTS: At 3 h, blood volume was equal in the A20 and C90 groups and lower in the C50 group. Oncotic pressure was reduced by 35-40% in the crystalloid groups and unchanged in the albumin group. Cortical water content in the A20 group was lower than in the C90 group (81.3 +/- 0.5% vs. 82.1 +/- 1.1%, P < 0.05), but it was not different from the C50 group (81.8 +/- 1.1%). At 24 h, oncotic pressure and blood volume were normalized in all groups, and cortical water content was significantly lower in the albumin group than in the crystalloid groups. Osmolality and arterial pressure were equal in all groups throughout the experiment. CONCLUSIONS: When given to the same intravascular volume expansion, isotonic crystalloids caused greater posttraumatic brain edema than 5% albumin at 3 and 24 h after trauma. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1595199
- author
- Jungner, Mårten LU ; Grände, Per-Olof LU ; Mattiasson, Gustav LU and Bentzer, Peter LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Anesthesiology
- volume
- 112
- issue
- 5
- pages
- 1194 - 1203
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- wos:000277284800024
- pmid:20395822
- scopus:77951667504
- pmid:20395822
- ISSN
- 1528-1175
- DOI
- 10.1097/ALN.0b013e3181d94d6e
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Anaesthesiology and Intensive Care (013230022), Laboratory for Experimental Brain Research (013041000)
- id
- 275928dc-dbff-46c7-b773-794d707281be (old id 1595199)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/20395822?dopt=Abstract
- date added to LUP
- 2016-04-04 07:40:33
- date last changed
- 2022-04-07 22:57:16
@article{275928dc-dbff-46c7-b773-794d707281be, abstract = {{BACKGROUND: It has been hypothesized that resuscitation with crystalloids after brain trauma increases brain edema compared with colloids, but previous studies on the subject have been inconclusive. To test this hypothesis, the authors compared groups resuscitated with either colloid or crystalloid. METHODS: After fluid percussion injury, rats were subjected to a controlled hemorrhage of 20 ml/kg and were randomized to 5% albumin at 20 ml/kg (A20), isotonic Ringer's acetate at 50 ml/kg (C50), or 90 ml/kg (C90). After 3 or 24 h, water content in the injured cortex was determined using a wet/dry weight method. Blood volume was calculated from plasma volume, measured by 125I-albumin dilution, and hematocrit. Oncotic pressure and osmolality were measured with osmometers. RESULTS: At 3 h, blood volume was equal in the A20 and C90 groups and lower in the C50 group. Oncotic pressure was reduced by 35-40% in the crystalloid groups and unchanged in the albumin group. Cortical water content in the A20 group was lower than in the C90 group (81.3 +/- 0.5% vs. 82.1 +/- 1.1%, P < 0.05), but it was not different from the C50 group (81.8 +/- 1.1%). At 24 h, oncotic pressure and blood volume were normalized in all groups, and cortical water content was significantly lower in the albumin group than in the crystalloid groups. Osmolality and arterial pressure were equal in all groups throughout the experiment. CONCLUSIONS: When given to the same intravascular volume expansion, isotonic crystalloids caused greater posttraumatic brain edema than 5% albumin at 3 and 24 h after trauma.}}, author = {{Jungner, Mårten and Grände, Per-Olof and Mattiasson, Gustav and Bentzer, Peter}}, issn = {{1528-1175}}, language = {{eng}}, number = {{5}}, pages = {{1194--1203}}, publisher = {{Lippincott Williams & Wilkins}}, series = {{Anesthesiology}}, title = {{Effects on brain edema of crystalloid and albumin fluid resuscitation after brain trauma and hemorrhage in the rat.}}, url = {{http://dx.doi.org/10.1097/ALN.0b013e3181d94d6e}}, doi = {{10.1097/ALN.0b013e3181d94d6e}}, volume = {{112}}, year = {{2010}}, }