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Estimated intake of milk fat is negatively associated with cardiovascular risk factors and does not increase the risk of a first acute myocardial infarction. A prospective case-control study

Warensjo, E; Jansson, JH; Berglund, L; Boman, K; Ahrén, Bo LU ; Weinehall, L; Lindahl, B; Hallmans, G and Vessby, B (2004) In British Journal of Nutrition 91(4). p.635-642
Abstract
Milk fat is high in saturated fatty acids (SFA) and high intakes of SFA are associated with cardiovascular diseases. The aim of the present study was to prospectively evaluate the potential risk of a first-ever acute myocardial infarction (AMI) in relation to the estimated milk-fat intake, reflected as the proportions of pentadecanoic acid (15: 0) and heptadecanoic acid (17: 0) in serum lipid esters. This was evaluated in a study population selected within the Vasterbotten Intervention Program and the northern Sweden 'Monitoring of Trends and Determinants in Cardiovascular disease' survey populations. A prospective case-control design was used. The proportions of the biomarkers were lower in the cases (n 78) than in the controls (n 156),... (More)
Milk fat is high in saturated fatty acids (SFA) and high intakes of SFA are associated with cardiovascular diseases. The aim of the present study was to prospectively evaluate the potential risk of a first-ever acute myocardial infarction (AMI) in relation to the estimated milk-fat intake, reflected as the proportions of pentadecanoic acid (15: 0) and heptadecanoic acid (17: 0) in serum lipid esters. This was evaluated in a study population selected within the Vasterbotten Intervention Program and the northern Sweden 'Monitoring of Trends and Determinants in Cardiovascular disease' survey populations. A prospective case-control design was used. The proportions of the biomarkers were lower in the cases (n 78) than in the controls (n 156), who were matched for age, sex, sampling time and geographical region. The standardised odds ratios of becoming an AMI case were between 0.7 and 0.8 for the biomarkers. The proportions of 15: 0 and 17: 0 in serum phospholipids were significantly and negatively correlated to serum concentrations of plasminogen activator inhibitor-1, tissue-type plasminogen activator, triacylglycerols, insulin, specific insulin, pro-insulin and leptin (all P<0.0001), suggesting a negative relationship to the insulin-resistance syndrome and the risk of CHD. Adjustment for BMI did not materially change the relationships. Although there seems to be a negative association between milk-fat intake as mirrored by the proportions of 15: 0 and 17: 0 in serum lipid esters and a first-ever AMI, adjustment for clinical risk factors removed this relationship. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
milk fat, pentadecanoic acid, heptadecanoic acid, infarction, acute myocardial
in
British Journal of Nutrition
volume
91
issue
4
pages
635 - 642
publisher
Cambridge University Press
external identifiers
  • pmid:15035691
  • wos:000221224300015
  • scopus:2342453941
ISSN
1475-2662
DOI
10.1079/BJN20041080
language
English
LU publication?
yes
id
bee48b4a-1d48-4394-b6c4-9e0b04c60816 (old id 279955)
date added to LUP
2007-11-05 10:44:01
date last changed
2017-12-10 03:51:02
@article{bee48b4a-1d48-4394-b6c4-9e0b04c60816,
  abstract     = {Milk fat is high in saturated fatty acids (SFA) and high intakes of SFA are associated with cardiovascular diseases. The aim of the present study was to prospectively evaluate the potential risk of a first-ever acute myocardial infarction (AMI) in relation to the estimated milk-fat intake, reflected as the proportions of pentadecanoic acid (15: 0) and heptadecanoic acid (17: 0) in serum lipid esters. This was evaluated in a study population selected within the Vasterbotten Intervention Program and the northern Sweden 'Monitoring of Trends and Determinants in Cardiovascular disease' survey populations. A prospective case-control design was used. The proportions of the biomarkers were lower in the cases (n 78) than in the controls (n 156), who were matched for age, sex, sampling time and geographical region. The standardised odds ratios of becoming an AMI case were between 0.7 and 0.8 for the biomarkers. The proportions of 15: 0 and 17: 0 in serum phospholipids were significantly and negatively correlated to serum concentrations of plasminogen activator inhibitor-1, tissue-type plasminogen activator, triacylglycerols, insulin, specific insulin, pro-insulin and leptin (all P&lt;0.0001), suggesting a negative relationship to the insulin-resistance syndrome and the risk of CHD. Adjustment for BMI did not materially change the relationships. Although there seems to be a negative association between milk-fat intake as mirrored by the proportions of 15: 0 and 17: 0 in serum lipid esters and a first-ever AMI, adjustment for clinical risk factors removed this relationship.},
  author       = {Warensjo, E and Jansson, JH and Berglund, L and Boman, K and Ahrén, Bo and Weinehall, L and Lindahl, B and Hallmans, G and Vessby, B},
  issn         = {1475-2662},
  keyword      = {milk fat,pentadecanoic acid,heptadecanoic acid,infarction,acute myocardial},
  language     = {eng},
  number       = {4},
  pages        = {635--642},
  publisher    = {Cambridge University Press},
  series       = {British Journal of Nutrition},
  title        = {Estimated intake of milk fat is negatively associated with cardiovascular risk factors and does not increase the risk of a first acute myocardial infarction. A prospective case-control study},
  url          = {http://dx.doi.org/10.1079/BJN20041080},
  volume       = {91},
  year         = {2004},
}