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Neural Stem Cell-Based Therapy for Ischemic Stroke

Kokaia, Zaal LU and Darsalia, Vladimer LU (2011) In Translational Stroke Research 2(3). p.272-278
Abstract
Stem cell-based approaches for the treatment of stroke have been the subject of intensive research over the past decade. Based on accumulated experimental evidence, stem cell-based therapy is a very promising prospect for the development of a novel treatment to restore stroke-damaged brain and impaired neurological function. Studies performed on experimental animal models of stroke employed a variety of stem cell types from diverse sources and have demonstrated their ability to replace lost neurons and functionally integrate into the brain, modulate inflammation, and stimulate angiogenesis and neurogenesis from an endogenous stem cell pool, most likely through trophic actions. A few clinical trials in stroke patients using stem cell... (More)
Stem cell-based approaches for the treatment of stroke have been the subject of intensive research over the past decade. Based on accumulated experimental evidence, stem cell-based therapy is a very promising prospect for the development of a novel treatment to restore stroke-damaged brain and impaired neurological function. Studies performed on experimental animal models of stroke employed a variety of stem cell types from diverse sources and have demonstrated their ability to replace lost neurons and functionally integrate into the brain, modulate inflammation, and stimulate angiogenesis and neurogenesis from an endogenous stem cell pool, most likely through trophic actions. A few clinical trials in stroke patients using stem cell transplantation have been completed or are on-going but the results have not yet proven the effectiveness of the stem cell-based approaches. A joint effort of stroke researchers and clinicians is needed to further optimize treatment protocols using safe and reproducible stem cell sources tested in relevant animal models of stroke and showing substantial neurological recovery of stroke-impaired function. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Stroke, Stem cells, Neurogenesis, Transplantation, Neuroregeneration, Clinical translation
in
Translational Stroke Research
volume
2
issue
3
pages
272 - 278
publisher
Springer
external identifiers
  • wos:000304163500007
ISSN
1868-4483
DOI
10.1007/s12975-011-0100-6
language
English
LU publication?
yes
id
0541f5cf-50b1-4399-863f-98f85b5dc528 (old id 2812827)
date added to LUP
2012-07-03 10:24:18
date last changed
2016-04-15 18:05:13
@article{0541f5cf-50b1-4399-863f-98f85b5dc528,
  abstract     = {Stem cell-based approaches for the treatment of stroke have been the subject of intensive research over the past decade. Based on accumulated experimental evidence, stem cell-based therapy is a very promising prospect for the development of a novel treatment to restore stroke-damaged brain and impaired neurological function. Studies performed on experimental animal models of stroke employed a variety of stem cell types from diverse sources and have demonstrated their ability to replace lost neurons and functionally integrate into the brain, modulate inflammation, and stimulate angiogenesis and neurogenesis from an endogenous stem cell pool, most likely through trophic actions. A few clinical trials in stroke patients using stem cell transplantation have been completed or are on-going but the results have not yet proven the effectiveness of the stem cell-based approaches. A joint effort of stroke researchers and clinicians is needed to further optimize treatment protocols using safe and reproducible stem cell sources tested in relevant animal models of stroke and showing substantial neurological recovery of stroke-impaired function.},
  author       = {Kokaia, Zaal and Darsalia, Vladimer},
  issn         = {1868-4483},
  keyword      = {Stroke,Stem cells,Neurogenesis,Transplantation,Neuroregeneration,Clinical translation},
  language     = {eng},
  number       = {3},
  pages        = {272--278},
  publisher    = {Springer},
  series       = {Translational Stroke Research},
  title        = {Neural Stem Cell-Based Therapy for Ischemic Stroke},
  url          = {http://dx.doi.org/10.1007/s12975-011-0100-6},
  volume       = {2},
  year         = {2011},
}