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Effects of microwaves from GSM mobile phones on the blood-brain barrier and neurons in rat brain

Persson, Bertil R.R. LU ; Eberhardt, Jacob LU ; Malmgren, Lars LU ; Persson, Mikael B. ; Brun, Arne LU and Salford, Leif G. LU (2005) Progress in Electromagnetics Research Symposium, PIERS 2005 In PIERS 2005 - Progress in Electromagnetics Research Symposium, Proceedings p.638-641
Abstract

Our group has since 1988 studied the effects of different intensities and modulations of 915MHz RF in a rat model where the exposure takes place in a TEM-cell during various time periods and post exposure recovery times. The power fed into TEM-cells was 0.125, 1.25, 12.5 or 125mW corresponding to whole body SAR (determined experimentally): 0.2, 2, 20 or 200mW/kg. The rats were awake and not restrained during exposure and after the recovery period the animals were anaesthetized and sacrificed by perfusion-fixation with 4% formaldehyde. Paraffin embedded 5 μm. thick brain slices were stained for albumin by applying albumin antibodies (Dakopatts), by which albumin is revealed as brownish discolorations. Dark neurons were revealed by... (More)

Our group has since 1988 studied the effects of different intensities and modulations of 915MHz RF in a rat model where the exposure takes place in a TEM-cell during various time periods and post exposure recovery times. The power fed into TEM-cells was 0.125, 1.25, 12.5 or 125mW corresponding to whole body SAR (determined experimentally): 0.2, 2, 20 or 200mW/kg. The rats were awake and not restrained during exposure and after the recovery period the animals were anaesthetized and sacrificed by perfusion-fixation with 4% formaldehyde. Paraffin embedded 5 μm. thick brain slices were stained for albumin by applying albumin antibodies (Dakopatts), by which albumin is revealed as brownish discolorations. Dark neurons were revealed by staining for RNA/DNA with cresyl violet. In series of more than 1800 Fisher rats, we have proven that sub thermal power levels from both pulse-modulated and continuous RF fields - including those from real GSM mobile phones - have the potency to significantly open the BBB for the animals' own albumin (but not fibrinogen) to pass out into the brain and to accumulate in the neurons and glial cells surrounding the capillaries. Albumin extravasations are most prominent at the lower SAR values. This dose-response behaviour suggests some kind of energy or electromagnetic field strength windowing effect. A linear dose-response relationship for dark neurons was found at 50 days after exposure, with most prominent occurrence at SAR 200mW/kg.

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organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
host publication
PIERS 2005 - Progress in Electromagnetics Research Symposium, Proceedings
series title
PIERS 2005 - Progress in Electromagnetics Research Symposium, Proceedings
pages
4 pages
publisher
Electromagnetics Academy
conference name
Progress in Electromagnetics Research Symposium, PIERS 2005
conference location
Hangzhou, China
conference dates
2005-08-22 - 2005-08-26
external identifiers
  • scopus:45749090289
ISBN
1933077077
9781933077079
language
English
LU publication?
yes
id
2835f6b7-826d-4d0b-add6-aaf4b434608d
date added to LUP
2020-05-07 20:59:17
date last changed
2021-01-04 14:44:43
@inproceedings{2835f6b7-826d-4d0b-add6-aaf4b434608d,
  abstract     = {<p>Our group has since 1988 studied the effects of different intensities and modulations of 915MHz RF in a rat model where the exposure takes place in a TEM-cell during various time periods and post exposure recovery times. The power fed into TEM-cells was 0.125, 1.25, 12.5 or 125mW corresponding to whole body SAR (determined experimentally): 0.2, 2, 20 or 200mW/kg. The rats were awake and not restrained during exposure and after the recovery period the animals were anaesthetized and sacrificed by perfusion-fixation with 4% formaldehyde. Paraffin embedded 5 μm. thick brain slices were stained for albumin by applying albumin antibodies (Dakopatts), by which albumin is revealed as brownish discolorations. Dark neurons were revealed by staining for RNA/DNA with cresyl violet. In series of more than 1800 Fisher rats, we have proven that sub thermal power levels from both pulse-modulated and continuous RF fields - including those from real GSM mobile phones - have the potency to significantly open the BBB for the animals' own albumin (but not fibrinogen) to pass out into the brain and to accumulate in the neurons and glial cells surrounding the capillaries. Albumin extravasations are most prominent at the lower SAR values. This dose-response behaviour suggests some kind of energy or electromagnetic field strength windowing effect. A linear dose-response relationship for dark neurons was found at 50 days after exposure, with most prominent occurrence at SAR 200mW/kg.</p>},
  author       = {Persson, Bertil R.R. and Eberhardt, Jacob and Malmgren, Lars and Persson, Mikael B. and Brun, Arne and Salford, Leif G.},
  booktitle    = {PIERS 2005 - Progress in Electromagnetics Research Symposium, Proceedings},
  isbn         = {1933077077},
  language     = {eng},
  month        = {12},
  pages        = {638--641},
  publisher    = {Electromagnetics Academy},
  series       = {PIERS 2005 - Progress in Electromagnetics Research Symposium, Proceedings},
  title        = {Effects of microwaves from GSM mobile phones on the blood-brain barrier and neurons in rat brain},
  year         = {2005},
}