Advanced

CSF Biomarkers Correlate with Cerebral Blood Flow on SPECT in Healthy Elderly.

Stomrud, Erik LU ; Forsberg, Karl-Anton; Hägerström, Douglas LU ; Ryding, Erik; Blennow, Kaj; Zetterberg, Henrik; Minthon, Lennart LU ; Hansson, Oskar LU and Londos, Elisabet LU (2012) In Dementia and Geriatric Cognitive Disorders 33(2-3). p.156-163
Abstract
Background:

The preclinical patterns of biological markers for Alzheimer's disease (AD) in vivo need further exploration. The aim of this study was therefore to investigate CSF biomarkers, regional cerebral blood flow (rCBF) and cognitive performance in cognitively healthy older individuals.



Method:

Within a 2-week period, 32 cognitively healthy older individuals underwent CSF analysis, rCBF measurement and cognitive testing. The CSF was analysed for β-amyloid(1-42) (Aβ42), total tau protein (T-tau) and hyperphosphorylated tau protein (P-tau). The rCBF results were analysed with statistical parametric mapping to investigate rCBF covariance with the other measurements.



Results:... (More)
Background:

The preclinical patterns of biological markers for Alzheimer's disease (AD) in vivo need further exploration. The aim of this study was therefore to investigate CSF biomarkers, regional cerebral blood flow (rCBF) and cognitive performance in cognitively healthy older individuals.



Method:

Within a 2-week period, 32 cognitively healthy older individuals underwent CSF analysis, rCBF measurement and cognitive testing. The CSF was analysed for β-amyloid(1-42) (Aβ42), total tau protein (T-tau) and hyperphosphorylated tau protein (P-tau). The rCBF results were analysed with statistical parametric mapping to investigate rCBF covariance with the other measurements.



Results:

High CSF P-tau and T-tau levels correlated with decreased rCBF in the right superior posterior medial frontal lobe whereas high CSF P-tau levels also correlated with increased rCBF in the left fronto-temporal border zone area. No significant covariance was seen between rCBF and CSF Aβ42. Neither CSF P-tau and T-tau levels nor rCBF in the current right frontal and left posterior locations were associated with cognitive performance.



Conclusions:

Our findings suggest a possible correlation between tau pathology and blood flow abnormalities in individuals without any overt cognitive symptoms. An association with AD development is possible but other explanatory mechanisms cannot be excluded. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Dementia and Geriatric Cognitive Disorders
volume
33
issue
2-3
pages
156 - 163
publisher
Karger
external identifiers
  • wos:000305654800012
  • pmid:22722670
  • scopus:84862842616
ISSN
1420-8008
DOI
10.1159/000338185
language
English
LU publication?
yes
id
73750883-fb3c-48e3-99f1-778321289cb5 (old id 2859136)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22722670?dopt=Abstract
date added to LUP
2012-07-04 19:30:54
date last changed
2017-01-01 03:12:43
@article{73750883-fb3c-48e3-99f1-778321289cb5,
  abstract     = {Background: <br/><br>
The preclinical patterns of biological markers for Alzheimer's disease (AD) in vivo need further exploration. The aim of this study was therefore to investigate CSF biomarkers, regional cerebral blood flow (rCBF) and cognitive performance in cognitively healthy older individuals. <br/><br>
<br/><br>
Method: <br/><br>
Within a 2-week period, 32 cognitively healthy older individuals underwent CSF analysis, rCBF measurement and cognitive testing. The CSF was analysed for β-amyloid(1-42) (Aβ42), total tau protein (T-tau) and hyperphosphorylated tau protein (P-tau). The rCBF results were analysed with statistical parametric mapping to investigate rCBF covariance with the other measurements. <br/><br>
<br/><br>
Results: <br/><br>
High CSF P-tau and T-tau levels correlated with decreased rCBF in the right superior posterior medial frontal lobe whereas high CSF P-tau levels also correlated with increased rCBF in the left fronto-temporal border zone area. No significant covariance was seen between rCBF and CSF Aβ42. Neither CSF P-tau and T-tau levels nor rCBF in the current right frontal and left posterior locations were associated with cognitive performance. <br/><br>
<br/><br>
Conclusions: <br/><br>
Our findings suggest a possible correlation between tau pathology and blood flow abnormalities in individuals without any overt cognitive symptoms. An association with AD development is possible but other explanatory mechanisms cannot be excluded.},
  author       = {Stomrud, Erik and Forsberg, Karl-Anton and Hägerström, Douglas and Ryding, Erik and Blennow, Kaj and Zetterberg, Henrik and Minthon, Lennart and Hansson, Oskar and Londos, Elisabet},
  issn         = {1420-8008},
  language     = {eng},
  number       = {2-3},
  pages        = {156--163},
  publisher    = {Karger},
  series       = {Dementia and Geriatric Cognitive Disorders},
  title        = {CSF Biomarkers Correlate with Cerebral Blood Flow on SPECT in Healthy Elderly.},
  url          = {http://dx.doi.org/10.1159/000338185},
  volume       = {33},
  year         = {2012},
}