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Complement in the immunopathogenesis of rheumatic disease.

Sturfelt, Gunnar LU and Truedsson, Lennart LU (2012) In Nature Reviews Rheumatology 8(8). p.458-468
Abstract
The complement system has vital protective functions as a humoral component of the innate immune system and also through interactions with the adaptive immune system; however, when inappropriately activated or regulated, complement can cause inflammation and organ damage, and such processes are involved in the pathogenesis of many inflammatory conditions, not least rheumatic diseases. Furthermore, states of complement deficiency can predispose not only to infections, but also to autoimmune disorders, including rheumatic diseases such as systemic lupus erythematosus. In this Review, the mechanisms behind the pathogenic activities of complement in rheumatic diseases are discussed. Potential approaches to therapeutic intervention that focus... (More)
The complement system has vital protective functions as a humoral component of the innate immune system and also through interactions with the adaptive immune system; however, when inappropriately activated or regulated, complement can cause inflammation and organ damage, and such processes are involved in the pathogenesis of many inflammatory conditions, not least rheumatic diseases. Furthermore, states of complement deficiency can predispose not only to infections, but also to autoimmune disorders, including rheumatic diseases such as systemic lupus erythematosus. In this Review, the mechanisms behind the pathogenic activities of complement in rheumatic diseases are discussed. Potential approaches to therapeutic intervention that focus on regulating complement activities in these disorders are also considered. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nature Reviews Rheumatology
volume
8
issue
8
pages
458 - 468
publisher
Nature Publishing Group
external identifiers
  • wos:000307098000006
  • pmid:22664835
  • scopus:84864580509
ISSN
1759-4804
DOI
10.1038/nrrheum.2012.75
language
English
LU publication?
yes
id
d9b9cdda-3940-46ad-8b91-95dd28ebfa42 (old id 2859813)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22664835?dopt=Abstract
date added to LUP
2012-07-04 12:08:02
date last changed
2017-09-03 04:47:34
@article{d9b9cdda-3940-46ad-8b91-95dd28ebfa42,
  abstract     = {The complement system has vital protective functions as a humoral component of the innate immune system and also through interactions with the adaptive immune system; however, when inappropriately activated or regulated, complement can cause inflammation and organ damage, and such processes are involved in the pathogenesis of many inflammatory conditions, not least rheumatic diseases. Furthermore, states of complement deficiency can predispose not only to infections, but also to autoimmune disorders, including rheumatic diseases such as systemic lupus erythematosus. In this Review, the mechanisms behind the pathogenic activities of complement in rheumatic diseases are discussed. Potential approaches to therapeutic intervention that focus on regulating complement activities in these disorders are also considered.},
  author       = {Sturfelt, Gunnar and Truedsson, Lennart},
  issn         = {1759-4804},
  language     = {eng},
  number       = {8},
  pages        = {458--468},
  publisher    = {Nature Publishing Group},
  series       = {Nature Reviews Rheumatology},
  title        = {Complement in the immunopathogenesis of rheumatic disease.},
  url          = {http://dx.doi.org/10.1038/nrrheum.2012.75},
  volume       = {8},
  year         = {2012},
}