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Is concordance with World Cancer Research Fund/American Institute for Cancer Research guidelines for cancer prevention related to subsequent risk of cancer? Results from the EPIC study

Romaguera, Dora; Vergnaud, Anne-Claire; Peeters, Petra H.; van Gils, Carla H.; Chan, Doris S. M.; Ferrari, Pietro; Romieu, Isabelle; Jenab, Mazda; Slimani, Nadia and Clavel-Chapelon, Francoise, et al. (2012) In American Journal of Clinical Nutrition 96(1). p.150-163
Abstract
Background: In 2007 the World Cancer Research Fund (WCRF) and the American Institute of Cancer Research (AICR) issued 8 recommendations (plus 2 special recommendations) on diet, physical activity, and weight management for cancer prevention on the basis of the most comprehensive collection of available evidence. Objective: We aimed to investigate whether concordance with the WCRF/AICR recommendations was related to cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Design: The present study included 386,355 EPIC participants from 9 European countries. At recruitment, dietary, anthropometric, and lifestyle information was collected. A score was constructed based on the WCRF/AICR recommendations on... (More)
Background: In 2007 the World Cancer Research Fund (WCRF) and the American Institute of Cancer Research (AICR) issued 8 recommendations (plus 2 special recommendations) on diet, physical activity, and weight management for cancer prevention on the basis of the most comprehensive collection of available evidence. Objective: We aimed to investigate whether concordance with the WCRF/AICR recommendations was related to cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Design: The present study included 386,355 EPIC participants from 9 European countries. At recruitment, dietary, anthropometric, and lifestyle information was collected. A score was constructed based on the WCRF/AICR recommendations on weight management, physical activity, foods and drinks that promote weight gain, plant foods, animal foods, alcoholic drinks, and breastfeeding for women; the score range was 0-6 for men and 0-7 for women. Higher scores indicated greater concordance with WCRF/AICR recommendations. The association between the score and cancer risk was estimated by using multivariable Cox regression models. Results: Concordance with the score was significantly associated with decreased risk of cancer. A 1-point increment in the score was associated with a risk reduction of 5% (95% Cl: 3%, 7%) for total cancer, 12% (95% CI: 9%, 16%) for colorectal cancer, and 16% (95% CI: 9%, 22%) for stomach cancer. Significant associations were also observed for cancers of the breast, endometrium, lung, kidney, upper aerodigestive tract, liver, and esophagus but not for prostate, ovarian, pancreatic, and bladder cancers. Conclusion: Adherence to the WCRF/AICR recommendations for cancer prevention may lower the risk of developing most types of cancer. Am J Clin Nutr 2012;96:150-63. (Less)
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American Journal of Clinical Nutrition
volume
96
issue
1
pages
150 - 163
publisher
American Society for Clinical Nutrition
external identifiers
  • wos:000305670100020
  • scopus:84863604928
ISSN
1938-3207
DOI
10.3945/ajcn.111.031674
language
English
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yes
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df796acd-00a1-4081-880c-3e4b624c1183 (old id 2863609)
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2012-08-01 09:43:10
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2017-09-24 04:06:47
@article{df796acd-00a1-4081-880c-3e4b624c1183,
  abstract     = {Background: In 2007 the World Cancer Research Fund (WCRF) and the American Institute of Cancer Research (AICR) issued 8 recommendations (plus 2 special recommendations) on diet, physical activity, and weight management for cancer prevention on the basis of the most comprehensive collection of available evidence. Objective: We aimed to investigate whether concordance with the WCRF/AICR recommendations was related to cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Design: The present study included 386,355 EPIC participants from 9 European countries. At recruitment, dietary, anthropometric, and lifestyle information was collected. A score was constructed based on the WCRF/AICR recommendations on weight management, physical activity, foods and drinks that promote weight gain, plant foods, animal foods, alcoholic drinks, and breastfeeding for women; the score range was 0-6 for men and 0-7 for women. Higher scores indicated greater concordance with WCRF/AICR recommendations. The association between the score and cancer risk was estimated by using multivariable Cox regression models. Results: Concordance with the score was significantly associated with decreased risk of cancer. A 1-point increment in the score was associated with a risk reduction of 5% (95% Cl: 3%, 7%) for total cancer, 12% (95% CI: 9%, 16%) for colorectal cancer, and 16% (95% CI: 9%, 22%) for stomach cancer. Significant associations were also observed for cancers of the breast, endometrium, lung, kidney, upper aerodigestive tract, liver, and esophagus but not for prostate, ovarian, pancreatic, and bladder cancers. Conclusion: Adherence to the WCRF/AICR recommendations for cancer prevention may lower the risk of developing most types of cancer. Am J Clin Nutr 2012;96:150-63.},
  author       = {Romaguera, Dora and Vergnaud, Anne-Claire and Peeters, Petra H. and van Gils, Carla H. and Chan, Doris S. M. and Ferrari, Pietro and Romieu, Isabelle and Jenab, Mazda and Slimani, Nadia and Clavel-Chapelon, Francoise and Fagherazzi, Guy and Perquier, Florence and Kaaks, Rudolf and Teucher, Birgit and Boeing, Heiner and von Ruesten, Anne and Tjonneland, Anne and Olsen, Anja and Dahm, Christina C. and Overvad, Kim and Ramon Quiros, Jose and Gonzalez, Carlos A. and Jose Sanchez, Maria and Navarro, Carmen and Barricarte, Aurelio and Dorronsoro, Miren and Khaw, Kay-Tee and Wareham, Nicholas J. and Crowe, Francesca L. and Key, Timothy J. and Trichopoulou, Antonia and Lagiou, Pagona and Bamia, Christina and Masala, Giovanna and Vineis, Paolo and Tumino, Rosario and Sieri, Sabina and Panico, Salvatore and May, Anne M. and Bueno-de-Mesquita, H. Bas and Buechner, Frederike L. and Wirfält, Elisabet and Manjer, Jonas and Johansson, Ingegerd and Hallmans, Goeran and Skeie, Guri and Benjaminsen Borch, Kristin and Parr, Christine L. and Riboli, Elio and Norat, Teresa},
  issn         = {1938-3207},
  language     = {eng},
  number       = {1},
  pages        = {150--163},
  publisher    = {American Society for Clinical Nutrition},
  series       = {American Journal of Clinical Nutrition},
  title        = {Is concordance with World Cancer Research Fund/American Institute for Cancer Research guidelines for cancer prevention related to subsequent risk of cancer? Results from the EPIC study},
  url          = {http://dx.doi.org/10.3945/ajcn.111.031674},
  volume       = {96},
  year         = {2012},
}