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Addition of cultured Schwann cells to tendon autografts and freeze-thawed muscle grafts improves peripheral nerve regeneration

Nishiura, Y; Brandt, Jerker LU ; Nilsson, Anna LU ; Kanje, Martin LU and Dahlin, Lars LU (2004) In Tissue Engineering 10(1-2). p.157-164
Abstract
The effects of addition of Schwann cells on peripheral nerve regeneration through a novel graft material-the tendon autograft-and a conventional freeze-thawed muscle graft, were studied in the rat sciatic nerve. Adult Schwann cell cultures were established from predegenerated nerves. The Schwann cells were added to the autologous grafts by coculture (tendon autograft) or injection (freeze-thawed muscle graft). Both graft types supported adherence of the added Schwann cells. Addition of cultured Schwann cells to the two different graft models improved regeneration by increasing the rate of axonal outgrowth as compared with similar grafts without added cells.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Tissue Engineering
volume
10
issue
1-2
pages
157 - 164
publisher
Mary Ann Liebert, Inc.
external identifiers
  • wos:000189028600017
  • scopus:1042266505
ISSN
1076-3279
language
English
LU publication?
yes
id
ef609c67-1412-45e8-b270-14db425fc21c (old id 286870)
date added to LUP
2007-08-03 16:11:29
date last changed
2017-11-05 04:28:47
@article{ef609c67-1412-45e8-b270-14db425fc21c,
  abstract     = {The effects of addition of Schwann cells on peripheral nerve regeneration through a novel graft material-the tendon autograft-and a conventional freeze-thawed muscle graft, were studied in the rat sciatic nerve. Adult Schwann cell cultures were established from predegenerated nerves. The Schwann cells were added to the autologous grafts by coculture (tendon autograft) or injection (freeze-thawed muscle graft). Both graft types supported adherence of the added Schwann cells. Addition of cultured Schwann cells to the two different graft models improved regeneration by increasing the rate of axonal outgrowth as compared with similar grafts without added cells.},
  author       = {Nishiura, Y and Brandt, Jerker and Nilsson, Anna and Kanje, Martin and Dahlin, Lars},
  issn         = {1076-3279},
  language     = {eng},
  number       = {1-2},
  pages        = {157--164},
  publisher    = {Mary Ann Liebert, Inc.},
  series       = {Tissue Engineering},
  title        = {Addition of cultured Schwann cells to tendon autografts and freeze-thawed muscle grafts improves peripheral nerve regeneration},
  volume       = {10},
  year         = {2004},
}