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Genes in the HLA class I region may contribute to the HLA class II-associated genetic susceptibility to multiple sclerosis

Harbo, HF; Lie, BA; Sawcer, S; Celius, EG; Dai, KZ; Oturai, A; Hillert, J; Lorentzen, AR; Laaksonen, M and Myhr, KM, et al. (2004) In Tissue Antigens 63(3). p.237-247
Abstract
In order to analyze whether loci in the human leukocyte antigen (HLA) class I region may contribute to the HLA class II-associated genetic susceptibility to multiple sclerosis (MS), we examined selected microsatellite markers in 177 Nordic sib-pair families, 222 British sib-pair families, 323 sporadic Norwegian MS patients and 386 Norwegian controls. All samples were, in addition, genotyped for the HLA-DR DQ haplotype, and the Norwegian case-control samples were also typed for HLA-A and -B loci. In the Norwegian sporadic MS patients association was seen with HLA-A, HLA-B, and with the D6S265 marker, located 100 kb centromeric to HLA-A. Associations with HLA-A and D6S265 loci were also suggested when restricting the analysis to HLA-DR15... (More)
In order to analyze whether loci in the human leukocyte antigen (HLA) class I region may contribute to the HLA class II-associated genetic susceptibility to multiple sclerosis (MS), we examined selected microsatellite markers in 177 Nordic sib-pair families, 222 British sib-pair families, 323 sporadic Norwegian MS patients and 386 Norwegian controls. All samples were, in addition, genotyped for the HLA-DR DQ haplotype, and the Norwegian case-control samples were also typed for HLA-A and -B loci. In the Norwegian sporadic MS patients association was seen with HLA-A, HLA-B, and with the D6S265 marker, located 100 kb centromeric to HLA-A. Associations with HLA-A and D6S265 loci were also suggested when restricting the analysis to HLA-DR15 haplotypes. In the sib-pair data a similar trend was seen with marker D6S265. Higher genotypic relative risk (GRR) was found for individuals who carry both HLA-DR15 and -A3 (GRR = 15), compared to those who carry only HLA-DR15 (GRR = 7), only HLA-A3 (GRR = 3) or none of these alleles (GRR = 1). The highest risk was conferred by a combination of HLA-DR15 and -A3 (odds ratio (OR) = 5.2). These results suggest that HLA-A or a gene in linkage disequilibrium with it may contribute to the HLA class II-associated genetic susceptibility to MS. (Less)
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Contribution to journal
publication status
published
subject
keywords
sclerosis, multiple, HLA-DR15, HLA-B7, HLA-A3, D6S265, genetic susceptibility
in
Tissue Antigens
volume
63
issue
3
pages
237 - 247
publisher
Wiley-Blackwell
external identifiers
  • wos:000188992000006
  • pmid:14989713
  • scopus:10744231677
ISSN
0001-2815
DOI
10.1111/j.0001-2815.2004.00173.x
language
English
LU publication?
yes
id
6426c0a7-9a89-4d71-b88c-4e9bf9bde907 (old id 286876)
date added to LUP
2007-10-22 14:32:39
date last changed
2017-11-15 14:17:21
@article{6426c0a7-9a89-4d71-b88c-4e9bf9bde907,
  abstract     = {In order to analyze whether loci in the human leukocyte antigen (HLA) class I region may contribute to the HLA class II-associated genetic susceptibility to multiple sclerosis (MS), we examined selected microsatellite markers in 177 Nordic sib-pair families, 222 British sib-pair families, 323 sporadic Norwegian MS patients and 386 Norwegian controls. All samples were, in addition, genotyped for the HLA-DR DQ haplotype, and the Norwegian case-control samples were also typed for HLA-A and -B loci. In the Norwegian sporadic MS patients association was seen with HLA-A, HLA-B, and with the D6S265 marker, located 100 kb centromeric to HLA-A. Associations with HLA-A and D6S265 loci were also suggested when restricting the analysis to HLA-DR15 haplotypes. In the sib-pair data a similar trend was seen with marker D6S265. Higher genotypic relative risk (GRR) was found for individuals who carry both HLA-DR15 and -A3 (GRR = 15), compared to those who carry only HLA-DR15 (GRR = 7), only HLA-A3 (GRR = 3) or none of these alleles (GRR = 1). The highest risk was conferred by a combination of HLA-DR15 and -A3 (odds ratio (OR) = 5.2). These results suggest that HLA-A or a gene in linkage disequilibrium with it may contribute to the HLA class II-associated genetic susceptibility to MS.},
  author       = {Harbo, HF and Lie, BA and Sawcer, S and Celius, EG and Dai, KZ and Oturai, A and Hillert, J and Lorentzen, AR and Laaksonen, M and Myhr, KM and Ryder, LP and Fredrikson, S and Nyland, H and Sorensen, PS and Sandberg Wollheim, Magnhild and Andersen, O and Svejgaard, A and Edland, A and Mellgren, SI and Compston, A and Vartdal, F and Spurkland, A},
  issn         = {0001-2815},
  keyword      = {sclerosis,multiple,HLA-DR15,HLA-B7,HLA-A3,D6S265,genetic susceptibility},
  language     = {eng},
  number       = {3},
  pages        = {237--247},
  publisher    = {Wiley-Blackwell},
  series       = {Tissue Antigens},
  title        = {Genes in the HLA class I region may contribute to the HLA class II-associated genetic susceptibility to multiple sclerosis},
  url          = {http://dx.doi.org/10.1111/j.0001-2815.2004.00173.x},
  volume       = {63},
  year         = {2004},
}