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Tea Consumption and Incidence of Type 2 Diabetes in Europe: The EPIC-InterAct Case-Cohort Study

van Woudenbergh, Geertruida J.; Kuijsten, Anneleen; Drogan, Dagmar; van der A, Daphne L.; Romaguera, Dora; Ardanaz, Eva; Amiano, Pilar; Barricarte, Aurelio; Beulens, Joline W. J. and Boeing, Heiner, et al. (2012) In PLoS ONE 7(5).
Abstract
Background: In previous meta-analyses, tea consumption has been associated with lower incidence of type 2 diabetes. It is unclear, however, if tea is associated inversely over the entire range of intake. Therefore, we investigated the association between tea consumption and incidence of type 2 diabetes in a European population. Methodology/Principal Findings: The EPIC-InterAct case-cohort study was conducted in 26 centers in 8 European countries and consists of a total of 12,403 incident type 2 diabetes cases and a stratified subcohort of 16,835 individuals from a total cohort of 340,234 participants with 3.99 million person-years of follow-up. Country-specific Hazard Ratios (HR) for incidence of type 2 diabetes were obtained after... (More)
Background: In previous meta-analyses, tea consumption has been associated with lower incidence of type 2 diabetes. It is unclear, however, if tea is associated inversely over the entire range of intake. Therefore, we investigated the association between tea consumption and incidence of type 2 diabetes in a European population. Methodology/Principal Findings: The EPIC-InterAct case-cohort study was conducted in 26 centers in 8 European countries and consists of a total of 12,403 incident type 2 diabetes cases and a stratified subcohort of 16,835 individuals from a total cohort of 340,234 participants with 3.99 million person-years of follow-up. Country-specific Hazard Ratios (HR) for incidence of type 2 diabetes were obtained after adjustment for lifestyle and dietary factors using a Cox regression adapted for a case-cohort design. Subsequently, country-specific HR were combined using a random effects meta-analysis. Tea consumption was studied as categorical variable (0, >0-<1, 1-<4, >= 4 cups/day). The dose-response of the association was further explored by restricted cubic spline regression. Country specific medians of tea consumption ranged from 0 cups/day in Spain to 4 cups/day in United Kingdom. Tea consumption was associated inversely with incidence of type 2 diabetes; the HR was 0.84 [95% CI 0.71, 1.00] when participants who drank >= 4 cups of tea per day were compared with non-drinkers (p(linear) (trend) = 0.04). Incidence of type 2 diabetes already tended to be lower with tea consumption of 1-<4 cups/day (HR = 0.93 [95% CI 0.81, 1.05]). Spline regression did not suggest a non-linear association (p(non-linearity) = 0.20). Conclusions/Significance: A linear inverse association was observed between tea consumption and incidence of type 2 diabetes. People who drink at least 4 cups of tea per day may have a 16% lower risk of developing type 2 diabetes than non-tea drinkers. (Less)
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PLoS ONE
volume
7
issue
5
publisher
Public Library of Science
external identifiers
  • wos:000305353400016
  • scopus:84867919618
ISSN
1932-6203
DOI
10.1371/journal.pone.0036910
language
English
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yes
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c67c28d8-e170-4809-b860-615beac3e68b (old id 2890638)
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2012-08-01 08:56:06
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2017-09-03 04:09:40
@article{c67c28d8-e170-4809-b860-615beac3e68b,
  abstract     = {Background: In previous meta-analyses, tea consumption has been associated with lower incidence of type 2 diabetes. It is unclear, however, if tea is associated inversely over the entire range of intake. Therefore, we investigated the association between tea consumption and incidence of type 2 diabetes in a European population. Methodology/Principal Findings: The EPIC-InterAct case-cohort study was conducted in 26 centers in 8 European countries and consists of a total of 12,403 incident type 2 diabetes cases and a stratified subcohort of 16,835 individuals from a total cohort of 340,234 participants with 3.99 million person-years of follow-up. Country-specific Hazard Ratios (HR) for incidence of type 2 diabetes were obtained after adjustment for lifestyle and dietary factors using a Cox regression adapted for a case-cohort design. Subsequently, country-specific HR were combined using a random effects meta-analysis. Tea consumption was studied as categorical variable (0, &gt;0-&lt;1, 1-&lt;4, &gt;= 4 cups/day). The dose-response of the association was further explored by restricted cubic spline regression. Country specific medians of tea consumption ranged from 0 cups/day in Spain to 4 cups/day in United Kingdom. Tea consumption was associated inversely with incidence of type 2 diabetes; the HR was 0.84 [95% CI 0.71, 1.00] when participants who drank &gt;= 4 cups of tea per day were compared with non-drinkers (p(linear) (trend) = 0.04). Incidence of type 2 diabetes already tended to be lower with tea consumption of 1-&lt;4 cups/day (HR = 0.93 [95% CI 0.81, 1.05]). Spline regression did not suggest a non-linear association (p(non-linearity) = 0.20). Conclusions/Significance: A linear inverse association was observed between tea consumption and incidence of type 2 diabetes. People who drink at least 4 cups of tea per day may have a 16% lower risk of developing type 2 diabetes than non-tea drinkers.},
  author       = {van Woudenbergh, Geertruida J. and Kuijsten, Anneleen and Drogan, Dagmar and van der A, Daphne L. and Romaguera, Dora and Ardanaz, Eva and Amiano, Pilar and Barricarte, Aurelio and Beulens, Joline W. J. and Boeing, Heiner and Bueno-de-Mesquita, H. Bas and Dahm, Christina C. and Chirlaque, M-Doleres and Clavel, Fran-coise and Crowe, Francesca L. and Eomois, Piia-Piret and Fagher-azzi, Guy and Franks, Paul and Halkjaer, Jytte and Khaw, Kay T. and Masala, Giovanna and Mattiello, Amalia and Nilsson, Peter and Overvad, Kim and Quiros, J. Ramon and Rolandsson, Olov and Romieu, Isabelle and Sacerdote, Carlotta and Sanchez, Maria-Jose and Schulze, Matthias B. and Slimani, Nadia and Sluijs, Ivonne and Spijkerman, Annemieke M. W. and Tagliabue, Giovanna and Teucher, Birgit and Tjonneland, Anne and Tumino, Rosario and Forouhi, Nita G. and Sharp, Stephen and Langenberg, Claudia and Feskens, Edith J. M. and Riboli, Elio and Wareham, Nicholas J.},
  issn         = {1932-6203},
  language     = {eng},
  number       = {5},
  publisher    = {Public Library of Science},
  series       = {PLoS ONE},
  title        = {Tea Consumption and Incidence of Type 2 Diabetes in Europe: The EPIC-InterAct Case-Cohort Study},
  url          = {http://dx.doi.org/10.1371/journal.pone.0036910},
  volume       = {7},
  year         = {2012},
}