Advanced

Biliodigestive shunt evokes hyperCCKemia and trophic effects in the rat pancreas, but not in the liver or gastrointestinal tract

Ohlsson, Bodil LU ; Axelson, Jan LU ; Hjalmarsson, Claes LU ; Rehfeld, Jens F and Ihse, Ingemar LU (1997) In Pancreas 14(3). p.255-261
Abstract
The influence of bile on the release of cholecystokinin (CCK) and, thereby, on the regulation of exocrine pancreatic function and growth is unsettled. The aim of this study was to elucidate the effect of long-term diversion of bile from the upper small intestine on CCK release and on the pancreas, liver, and gastrointestinal tract. A surgical biliodigestive shunt was performed in rats, diverting the bile flow directly to the middle of the small intestine. The animals were killed after 4 or 12 weeks. Plasma CCK and trophic effects on the pancreas, liver, and gastrointestinal tract were determined, as were the trypsin and chymotrypsin contents in the intestine. The CCK concentration in plasma increased 10-fold at both time points studied.... (More)
The influence of bile on the release of cholecystokinin (CCK) and, thereby, on the regulation of exocrine pancreatic function and growth is unsettled. The aim of this study was to elucidate the effect of long-term diversion of bile from the upper small intestine on CCK release and on the pancreas, liver, and gastrointestinal tract. A surgical biliodigestive shunt was performed in rats, diverting the bile flow directly to the middle of the small intestine. The animals were killed after 4 or 12 weeks. Plasma CCK and trophic effects on the pancreas, liver, and gastrointestinal tract were determined, as were the trypsin and chymotrypsin contents in the intestine. The CCK concentration in plasma increased 10-fold at both time points studied. The pancreas doubled its weight from 4 weeks onward. Also, pancreatic protein, DNA, and amylase contents were increased throughout the study. The liver and gastrointestinal tract were unaffected. Intraluminal bile plays a role in the feedback regulation of CCK release and is involved in this way in the control of pancreatic growth but has no similar effects on the liver or gastrointestinal tract. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
gastrointestinal tract, biliodigestive, liver
in
Pancreas
volume
14
issue
3
pages
255 - 261
publisher
Lippincott Williams & Wilkins
external identifiers
  • scopus:0030965548
ISSN
0885-3177
language
English
LU publication?
yes
id
b7d8996f-f8f2-4bb6-aa42-7dc33baa050e (old id 28920)
date added to LUP
2007-06-15 15:52:19
date last changed
2017-01-01 04:41:08
@article{b7d8996f-f8f2-4bb6-aa42-7dc33baa050e,
  abstract     = {The influence of bile on the release of cholecystokinin (CCK) and, thereby, on the regulation of exocrine pancreatic function and growth is unsettled. The aim of this study was to elucidate the effect of long-term diversion of bile from the upper small intestine on CCK release and on the pancreas, liver, and gastrointestinal tract. A surgical biliodigestive shunt was performed in rats, diverting the bile flow directly to the middle of the small intestine. The animals were killed after 4 or 12 weeks. Plasma CCK and trophic effects on the pancreas, liver, and gastrointestinal tract were determined, as were the trypsin and chymotrypsin contents in the intestine. The CCK concentration in plasma increased 10-fold at both time points studied. The pancreas doubled its weight from 4 weeks onward. Also, pancreatic protein, DNA, and amylase contents were increased throughout the study. The liver and gastrointestinal tract were unaffected. Intraluminal bile plays a role in the feedback regulation of CCK release and is involved in this way in the control of pancreatic growth but has no similar effects on the liver or gastrointestinal tract.},
  author       = {Ohlsson, Bodil and Axelson, Jan and Hjalmarsson, Claes and Rehfeld, Jens F and Ihse, Ingemar},
  issn         = {0885-3177},
  keyword      = {gastrointestinal tract,biliodigestive,liver},
  language     = {eng},
  number       = {3},
  pages        = {255--261},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Pancreas},
  title        = {Biliodigestive shunt evokes hyperCCKemia and trophic effects in the rat pancreas, but not in the liver or gastrointestinal tract},
  volume       = {14},
  year         = {1997},
}