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The SLC6A14 gene shows evidence of association with obesity

Suviolahti, E; Oksanen, LJ; Ohman, M; Cantor, RM; Ridderstråle, Martin LU ; Tuomi, T; Kaprio, J; Rissanen, A; Mustajoki, P and Jousilahti, P, et al. (2003) In Journal of Clinical Investigation 112(11). p.1762-1772
Abstract
In our previous genome-wide scan of Finnish nuclear families, obesity was linked to chromosome Xq24. Here we analyzed this 15-Mb region by genotyping 9 microsatellite markers and 36 single nucleotide polyp morphisms (SNPs) for 11 positional and functional candidate genes in an extended sample of 218 obese Finnish sibling pairs (sibpairs) (BMI > 30 kg/m(2)). Evidence of linkage emerged mainly from the obese male sibpairs, suggesting a gender-specific effect for the underlying gene. By constructing haplotypes among the obese male sibpairs, we restricted the region from 15 Mb to 4 Mb, between markers DXS8088 and DXS8067. Regional functional candidate genes were tested for association in an initial sample of 117 cases and 182 controls.... (More)
In our previous genome-wide scan of Finnish nuclear families, obesity was linked to chromosome Xq24. Here we analyzed this 15-Mb region by genotyping 9 microsatellite markers and 36 single nucleotide polyp morphisms (SNPs) for 11 positional and functional candidate genes in an extended sample of 218 obese Finnish sibling pairs (sibpairs) (BMI > 30 kg/m(2)). Evidence of linkage emerged mainly from the obese male sibpairs, suggesting a gender-specific effect for the underlying gene. By constructing haplotypes among the obese male sibpairs, we restricted the region from 15 Mb to 4 Mb, between markers DXS8088 and DXS8067. Regional functional candidate genes were tested for association in an initial sample of 117 cases and 182 controls. Significant evidence was observed for association for an SNP in the 3'-untranslated region of the solute carrier family 6 member 14 (SLC6A14) gene (P = 0.0002) and for SNP haplotypes of the SLC6A14 gene (P = 0.0007-0.006). Furthermore, an independent replication study sample of 837 cases and 968 controls from Finland and Sweden also showed significant differences in allele frequencies between obese and non-obese individuals (P = 0.003). The SLC6A14 gene is an interesting novel candidate for obesity because it encodes an amino acid transporter, which potentially regulates tryptophan availability for serotonin synthesis and thus possibly affects appetite control. (Less)
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Journal of Clinical Investigation
volume
112
issue
11
pages
1762 - 1772
publisher
The Journal of Clinical Investigation
external identifiers
  • wos:000187111800021
  • pmid:14660752
  • scopus:0347354997
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0021-9738
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English
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yes
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f0dffb42-5559-436f-ac24-fc7abd8d9498 (old id 293133)
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2007-09-22 13:53:45
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2018-05-29 09:43:40
@article{f0dffb42-5559-436f-ac24-fc7abd8d9498,
  abstract     = {In our previous genome-wide scan of Finnish nuclear families, obesity was linked to chromosome Xq24. Here we analyzed this 15-Mb region by genotyping 9 microsatellite markers and 36 single nucleotide polyp morphisms (SNPs) for 11 positional and functional candidate genes in an extended sample of 218 obese Finnish sibling pairs (sibpairs) (BMI > 30 kg/m(2)). Evidence of linkage emerged mainly from the obese male sibpairs, suggesting a gender-specific effect for the underlying gene. By constructing haplotypes among the obese male sibpairs, we restricted the region from 15 Mb to 4 Mb, between markers DXS8088 and DXS8067. Regional functional candidate genes were tested for association in an initial sample of 117 cases and 182 controls. Significant evidence was observed for association for an SNP in the 3'-untranslated region of the solute carrier family 6 member 14 (SLC6A14) gene (P = 0.0002) and for SNP haplotypes of the SLC6A14 gene (P = 0.0007-0.006). Furthermore, an independent replication study sample of 837 cases and 968 controls from Finland and Sweden also showed significant differences in allele frequencies between obese and non-obese individuals (P = 0.003). The SLC6A14 gene is an interesting novel candidate for obesity because it encodes an amino acid transporter, which potentially regulates tryptophan availability for serotonin synthesis and thus possibly affects appetite control.},
  author       = {Suviolahti, E and Oksanen, LJ and Ohman, M and Cantor, RM and Ridderstråle, Martin and Tuomi, T and Kaprio, J and Rissanen, A and Mustajoki, P and Jousilahti, P and Vartiainen, E and Silander, K and Kilpikari, R and Salomaa, V and Groop, Leif and Kontula, K and Peltonen, L and Pajukanta, P},
  issn         = {0021-9738},
  language     = {eng},
  number       = {11},
  pages        = {1762--1772},
  publisher    = {The Journal of Clinical Investigation},
  series       = {Journal of Clinical Investigation},
  title        = {The SLC6A14 gene shows evidence of association with obesity},
  url          = {http://dx.doi.org/},
  volume       = {112},
  year         = {2003},
}