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Radiation dose as a risk factor for malignant melanoma following childhood cancer

Guerin, S; Dupuy, A; Anderson, Harald LU ; Shamsaldin, A; Svahn-Tapper, Gudrun LU ; Moller, T; Quiniou, E; Garwicz, Stanislaw LU ; Hawkins, M and Avril, MF, et al. (2003) In European Journal of Cancer 39(16). p.2379-2386
Abstract
The aim of this study was to determine therapy-related risk factors for the development of melanoma after childhood cancer. Among 4401 3-year survivors of a childhood cancer in eight French and British centres and 25 120 patients younger than 20 years old at first malignant neoplasm (FMN) extracted from the Nordic Cancer Registries, 16 patients developed a melanoma as a second malignant neoplasm (SMN). A cohort study of the French and British cohorts was performed. In a nested case-control study, the 16 patients who developed a melanoma as a SMN (cases) were matched with 3-5 controls in their respective cohort according to gender, age at the first cancer, the calendar year of occurrence of the first cancer and follow-up. Radiotherapy... (More)
The aim of this study was to determine therapy-related risk factors for the development of melanoma after childhood cancer. Among 4401 3-year survivors of a childhood cancer in eight French and British centres and 25 120 patients younger than 20 years old at first malignant neoplasm (FMN) extracted from the Nordic Cancer Registries, 16 patients developed a melanoma as a second malignant neoplasm (SMN). A cohort study of the French and British cohorts was performed. In a nested case-control study, the 16 patients who developed a melanoma as a SMN (cases) were matched with 3-5 controls in their respective cohort according to gender, age at the first cancer, the calendar year of occurrence of the first cancer and follow-up. Radiotherapy appeared to increase the risk of melanoma for local doses > 15 Gy, Odds Ratio (OR)= 13 (95% Confidence Interval (CI): 0.94-174). Regarding chemotherapy, we observed an increased OR for both alkylating agents and spindle inhibitors, OR 2.7 (95% CI: 0.5-14). Children treated for a gonadal tumour as a FMN were found to be at a higher risk of melanoma, OR 8.7 (95% CI: 0.9-86). The adjusted OR for the local radiation dose was 1.07 (95% CI: 1.00-1.15). In conclusion, radiotherapy may contribute to an increased risk of melanoma as a SMN, but only at very high doses of low linear energy transfer radiation. Common genetic origins between gonadal tumours and malignant melanomas are likely. (C) 2003 Elsevier Ltd. All rights reserved. (Less)
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European Journal of Cancer
volume
39
issue
16
pages
2379 - 2386
publisher
IFAC & Elsevier Ltd.
external identifiers
  • wos:000186452000027
  • pmid:14556931
  • scopus:17444448286
ISSN
1879-0852
DOI
language
English
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yes
id
8914e32c-237e-4b68-a142-f8d04c1010be (old id 296132)
date added to LUP
2007-09-03 12:21:58
date last changed
2018-05-29 11:48:49
@article{8914e32c-237e-4b68-a142-f8d04c1010be,
  abstract     = {The aim of this study was to determine therapy-related risk factors for the development of melanoma after childhood cancer. Among 4401 3-year survivors of a childhood cancer in eight French and British centres and 25 120 patients younger than 20 years old at first malignant neoplasm (FMN) extracted from the Nordic Cancer Registries, 16 patients developed a melanoma as a second malignant neoplasm (SMN). A cohort study of the French and British cohorts was performed. In a nested case-control study, the 16 patients who developed a melanoma as a SMN (cases) were matched with 3-5 controls in their respective cohort according to gender, age at the first cancer, the calendar year of occurrence of the first cancer and follow-up. Radiotherapy appeared to increase the risk of melanoma for local doses > 15 Gy, Odds Ratio (OR)= 13 (95% Confidence Interval (CI): 0.94-174). Regarding chemotherapy, we observed an increased OR for both alkylating agents and spindle inhibitors, OR 2.7 (95% CI: 0.5-14). Children treated for a gonadal tumour as a FMN were found to be at a higher risk of melanoma, OR 8.7 (95% CI: 0.9-86). The adjusted OR for the local radiation dose was 1.07 (95% CI: 1.00-1.15). In conclusion, radiotherapy may contribute to an increased risk of melanoma as a SMN, but only at very high doses of low linear energy transfer radiation. Common genetic origins between gonadal tumours and malignant melanomas are likely. (C) 2003 Elsevier Ltd. All rights reserved.},
  author       = {Guerin, S and Dupuy, A and Anderson, Harald and Shamsaldin, A and Svahn-Tapper, Gudrun and Moller, T and Quiniou, E and Garwicz, Stanislaw and Hawkins, M and Avril, MF and Oberlin, O and Chavaudra, J and de Vathaire, F},
  issn         = {1879-0852},
  language     = {eng},
  number       = {16},
  pages        = {2379--2386},
  publisher    = {IFAC & Elsevier Ltd.},
  series       = {European Journal of Cancer},
  title        = {Radiation dose as a risk factor for malignant melanoma following childhood cancer},
  url          = {http://dx.doi.org/},
  volume       = {39},
  year         = {2003},
}