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Diagnostic delay and prognosis in invasive bladder cancer

Liedberg, Fredrik LU ; Anderson, Harald LU ; Mansson, A and Månsson, Wiking LU (2003) In Scandinavian Journal of Urology and Nephrology1967-01-01+01:002013-01-01+01:00 37(5). p.396-400
Abstract
Objectives: To study diagnostic delay in invasive bladder cancer in a population-based material with long-term follow-up, and to evaluate whether delay in diagnosis affects the risk of bladder cancer death. Material and Methods: In a previous study, 177 patients with invasive bladder cancer (T1-T4) diagnosed in 1988 were investigated with regard to diagnostic delay. A review of all available clinical records was performed. In the present study, causes of death for these patients were registered over a 12-year follow-up period, and the impact of diagnostic delay on bladder cancer death was studied by means of survival analysis. Results: The median diagnostic delay in the material was 144 days. When the patients were stratified into groups... (More)
Objectives: To study diagnostic delay in invasive bladder cancer in a population-based material with long-term follow-up, and to evaluate whether delay in diagnosis affects the risk of bladder cancer death. Material and Methods: In a previous study, 177 patients with invasive bladder cancer (T1-T4) diagnosed in 1988 were investigated with regard to diagnostic delay. A review of all available clinical records was performed. In the present study, causes of death for these patients were registered over a 12-year follow-up period, and the impact of diagnostic delay on bladder cancer death was studied by means of survival analysis. Results: The median diagnostic delay in the material was 144 days. When the patients were stratified into groups with diagnostic delays of 0-3, 3-6, 6-12 and >12 months, those with T1 tumours in the two groups with a diagnostic delay of <6 months showed a trend towards a decreased risk of bladder cancer death. In contrast, in patients with muscle-invasive disease, a significantly increased risk of bladder cancer death was noted for those with a diagnostic delay of <6 months. Conclusion: A trend towards better prognosis was found for patients with T1 tumours with a shorter diagnostic delay. The poor prognosis of patients with muscle-invasive disease and a short diagnostic delay suggests aggressive behaviour of the tumour and may explain the worse prognosis in these patients. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
bladder cancer, diagnostic delay, prognosis
in
Scandinavian Journal of Urology and Nephrology1967-01-01+01:002013-01-01+01:00
volume
37
issue
5
pages
396 - 400
publisher
Taylor & Francis
external identifiers
  • wos:000186295000006
  • pmid:14594688
  • scopus:0345304834
ISSN
0036-5599
DOI
10.1080/00365590310006246
language
English
LU publication?
yes
id
30f714b0-c444-4f7e-a227-440ad0d9c8ae (old id 296387)
date added to LUP
2007-09-16 12:25:11
date last changed
2017-02-22 11:44:30
@article{30f714b0-c444-4f7e-a227-440ad0d9c8ae,
  abstract     = {Objectives: To study diagnostic delay in invasive bladder cancer in a population-based material with long-term follow-up, and to evaluate whether delay in diagnosis affects the risk of bladder cancer death. Material and Methods: In a previous study, 177 patients with invasive bladder cancer (T1-T4) diagnosed in 1988 were investigated with regard to diagnostic delay. A review of all available clinical records was performed. In the present study, causes of death for these patients were registered over a 12-year follow-up period, and the impact of diagnostic delay on bladder cancer death was studied by means of survival analysis. Results: The median diagnostic delay in the material was 144 days. When the patients were stratified into groups with diagnostic delays of 0-3, 3-6, 6-12 and &gt;12 months, those with T1 tumours in the two groups with a diagnostic delay of &lt;6 months showed a trend towards a decreased risk of bladder cancer death. In contrast, in patients with muscle-invasive disease, a significantly increased risk of bladder cancer death was noted for those with a diagnostic delay of &lt;6 months. Conclusion: A trend towards better prognosis was found for patients with T1 tumours with a shorter diagnostic delay. The poor prognosis of patients with muscle-invasive disease and a short diagnostic delay suggests aggressive behaviour of the tumour and may explain the worse prognosis in these patients.},
  author       = {Liedberg, Fredrik and Anderson, Harald and Mansson, A and Månsson, Wiking},
  issn         = {0036-5599},
  keyword      = {bladder cancer,diagnostic delay,prognosis},
  language     = {eng},
  number       = {5},
  pages        = {396--400},
  publisher    = {Taylor & Francis},
  series       = {Scandinavian Journal of Urology and Nephrology1967-01-01+01:002013-01-01+01:00},
  title        = {Diagnostic delay and prognosis in invasive bladder cancer},
  url          = {http://dx.doi.org/10.1080/00365590310006246},
  volume       = {37},
  year         = {2003},
}