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Vaccination against encapsulated bacteria in hereditary C2 deficiency results in antibody response and opsonization due to antibody-dependent complement activation.

Jönsson, Göran LU ; Lood, Christian LU ; Gullstrand, Birgitta LU ; Holmström, Eva M LU ; Selander, Barbro; Braconier, Jean Henrik LU ; Sturfelt, Gunnar LU ; Bengtsson, Anders LU and Truedsson, Lennart LU (2012) In Clinical Immunology 144(3). p.214-227
Abstract
Hereditary C2 deficiency (C2D) is an important susceptibility factor for invasive infections caused by encapsulated bacteria such as pneumococci and Haemophilus influenzae type b. The infections are mostly seen in childhood indicating that antibody-mediated acquired immunity is affected. C2D persons and healthy controls were vaccinated with ActHIB® and Pneumo23®. Analysis of specific antibodies to pneumococci serotype 6B, 7F, and 23F, and Hib was performed. Post-vaccination IgG antibodies against pneumococci serotype 6B and 23F at a concentration ≥1.0mg/L was found in similar frequency in C2D persons and controls. Post-vaccination sera from C2D persons showed poor complement-mediated opsonization and phagocytosis of pneumococci by... (More)
Hereditary C2 deficiency (C2D) is an important susceptibility factor for invasive infections caused by encapsulated bacteria such as pneumococci and Haemophilus influenzae type b. The infections are mostly seen in childhood indicating that antibody-mediated acquired immunity is affected. C2D persons and healthy controls were vaccinated with ActHIB® and Pneumo23®. Analysis of specific antibodies to pneumococci serotype 6B, 7F, and 23F, and Hib was performed. Post-vaccination IgG antibodies against pneumococci serotype 6B and 23F at a concentration ≥1.0mg/L was found in similar frequency in C2D persons and controls. Post-vaccination sera from C2D persons showed poor complement-mediated opsonization and phagocytosis of pneumococci by granulocytes when depending on classical and lectin pathway activation only, but increased (p=0.007) and equaled that of the normal controls when also alternative pathway activation was allowed due to antibody-dependent C2 bypass activation. In conclusion, the C2D persons benefited from the vaccination and achieve an increased phagocytic capacity. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
Clinical Immunology
volume
144
issue
3
pages
214 - 227
publisher
Elsevier
external identifiers
  • wos:000308049100004
  • pmid:22842196
  • scopus:84864141220
ISSN
1521-6616
DOI
10.1016/j.clim.2012.06.008
language
English
LU publication?
yes
id
76487451-3bff-45fc-b21d-29cc481a827c (old id 2966429)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22842196?dopt=Abstract
date added to LUP
2012-08-10 09:09:25
date last changed
2017-08-27 03:19:51
@article{76487451-3bff-45fc-b21d-29cc481a827c,
  abstract     = {Hereditary C2 deficiency (C2D) is an important susceptibility factor for invasive infections caused by encapsulated bacteria such as pneumococci and Haemophilus influenzae type b. The infections are mostly seen in childhood indicating that antibody-mediated acquired immunity is affected. C2D persons and healthy controls were vaccinated with ActHIB® and Pneumo23®. Analysis of specific antibodies to pneumococci serotype 6B, 7F, and 23F, and Hib was performed. Post-vaccination IgG antibodies against pneumococci serotype 6B and 23F at a concentration ≥1.0mg/L was found in similar frequency in C2D persons and controls. Post-vaccination sera from C2D persons showed poor complement-mediated opsonization and phagocytosis of pneumococci by granulocytes when depending on classical and lectin pathway activation only, but increased (p=0.007) and equaled that of the normal controls when also alternative pathway activation was allowed due to antibody-dependent C2 bypass activation. In conclusion, the C2D persons benefited from the vaccination and achieve an increased phagocytic capacity.},
  author       = {Jönsson, Göran and Lood, Christian and Gullstrand, Birgitta and Holmström, Eva M and Selander, Barbro and Braconier, Jean Henrik and Sturfelt, Gunnar and Bengtsson, Anders and Truedsson, Lennart},
  issn         = {1521-6616},
  language     = {eng},
  number       = {3},
  pages        = {214--227},
  publisher    = {Elsevier},
  series       = {Clinical Immunology},
  title        = {Vaccination against encapsulated bacteria in hereditary C2 deficiency results in antibody response and opsonization due to antibody-dependent complement activation.},
  url          = {http://dx.doi.org/10.1016/j.clim.2012.06.008},
  volume       = {144},
  year         = {2012},
}