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Cross-talk between neural stem cells and immune cells: the key to better brain repair?

Kokaia, Zaal LU ; Martino, Gianvito; Schwartz, Michal and Lindvall, Olle LU (2012) In Nature Neuroscience 15(8). p.1078-1087
Abstract
Systemic or intracerebral delivery of neural stem and progenitor cells (NSPCs) and activation of endogenous NSPCs hold much promise as potential treatments for diseases in the human CNS. Recent studies have shed new light on the interaction between the NSPCs and cells belonging to the innate and adaptive arms of the immune system. According to these studies, the immune cells can be both beneficial and detrimental for cell genesis from grafted and endogenous NSPCs in the CNS, and the NSPCs exert their beneficial effects not only by cell replacement but also by immunomodulation and trophic support. The cross-talk between immune cells and NSPCs and their progeny seems to determine both the efficacy of endogenous regenerative responses and the... (More)
Systemic or intracerebral delivery of neural stem and progenitor cells (NSPCs) and activation of endogenous NSPCs hold much promise as potential treatments for diseases in the human CNS. Recent studies have shed new light on the interaction between the NSPCs and cells belonging to the innate and adaptive arms of the immune system. According to these studies, the immune cells can be both beneficial and detrimental for cell genesis from grafted and endogenous NSPCs in the CNS, and the NSPCs exert their beneficial effects not only by cell replacement but also by immunomodulation and trophic support. The cross-talk between immune cells and NSPCs and their progeny seems to determine both the efficacy of endogenous regenerative responses and the mechanism of action as well as the fate and functional integration of grafted NSPCs. Better understanding of the dialog between NSPCs and innate and adaptive immune cells is crucial for further development of effective strategies for CNS repair. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nature Neuroscience
volume
15
issue
8
pages
1078 - 1087
publisher
Nature Publishing Group
external identifiers
  • wos:000306844500009
  • pmid:22837038
  • scopus:84864449051
ISSN
1546-1726
DOI
10.1038/nn.3163
language
English
LU publication?
yes
id
2816c672-2a0e-49f2-8286-3e4f4b30d4f2 (old id 2966478)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22837038?dopt=Abstract
date added to LUP
2012-08-10 09:22:38
date last changed
2017-04-23 04:40:46
@article{2816c672-2a0e-49f2-8286-3e4f4b30d4f2,
  abstract     = {Systemic or intracerebral delivery of neural stem and progenitor cells (NSPCs) and activation of endogenous NSPCs hold much promise as potential treatments for diseases in the human CNS. Recent studies have shed new light on the interaction between the NSPCs and cells belonging to the innate and adaptive arms of the immune system. According to these studies, the immune cells can be both beneficial and detrimental for cell genesis from grafted and endogenous NSPCs in the CNS, and the NSPCs exert their beneficial effects not only by cell replacement but also by immunomodulation and trophic support. The cross-talk between immune cells and NSPCs and their progeny seems to determine both the efficacy of endogenous regenerative responses and the mechanism of action as well as the fate and functional integration of grafted NSPCs. Better understanding of the dialog between NSPCs and innate and adaptive immune cells is crucial for further development of effective strategies for CNS repair.},
  author       = {Kokaia, Zaal and Martino, Gianvito and Schwartz, Michal and Lindvall, Olle},
  issn         = {1546-1726},
  language     = {eng},
  number       = {8},
  pages        = {1078--1087},
  publisher    = {Nature Publishing Group},
  series       = {Nature Neuroscience},
  title        = {Cross-talk between neural stem cells and immune cells: the key to better brain repair?},
  url          = {http://dx.doi.org/10.1038/nn.3163},
  volume       = {15},
  year         = {2012},
}