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Sex differences in coeliac disease risk: A Swedish sibling design study.

Wingren, Carl Johan LU ; Agardh, Daniel LU and Merlo, Juan LU (2012) In Digestive and Liver Disease 44(11). p.909-913
Abstract
BACKGROUND:

For unknown reasons girls are at an increased risk of coeliac disease compared to boys. However, the observed association might be confounded, since maternal coeliac disease is associated with both an increased risk of the disease in first-degree relatives as well as an increased ratio of girls to boys in offspring.



AIMS:

We investigate the effect of sex on the risk of coeliac disease before the age of two years using sibling design.



METHODS:

We identified all singleton children (n=792,401) born between 1987 and 1993 in Sweden using the Swedish Medical Birth Registry. Coeliac disease cases (2264) were identified using the Swedish National Inpatient Registry.... (More)
BACKGROUND:

For unknown reasons girls are at an increased risk of coeliac disease compared to boys. However, the observed association might be confounded, since maternal coeliac disease is associated with both an increased risk of the disease in first-degree relatives as well as an increased ratio of girls to boys in offspring.



AIMS:

We investigate the effect of sex on the risk of coeliac disease before the age of two years using sibling design.



METHODS:

We identified all singleton children (n=792,401) born between 1987 and 1993 in Sweden using the Swedish Medical Birth Registry. Coeliac disease cases (2264) were identified using the Swedish National Inpatient Registry. We applied both conventional population-based Cox regression models and sibling designs modelling the association in sex discordant siblings.



RESULTS:

We observed a conclusively increased risk of coeliac disease in girls compared to boys, using both sibling design (hazard ratio 1.67, 95% confidence interval 1.44-1.93) and conventional Cox regression analysis (hazard ratio 1.75, 95% confidence interval 1.61-1.91) that could not be explained by perinatal factors previously associated with the disease.



CONCLUSIONS:

We confirm that female sex is causally associated with childhood coeliac disease, but the reasons remains unknown. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Digestive and Liver Disease
volume
44
issue
11
pages
909 - 913
publisher
Elsevier
external identifiers
  • wos:000311016500006
  • pmid:22824835
  • scopus:84866975617
ISSN
1590-8658
DOI
10.1016/j.dld.2012.06.016
language
English
LU publication?
yes
id
6e77da5d-3582-46a6-83de-2991f9a6d3f4 (old id 2966737)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22824835?dopt=Abstract
date added to LUP
2012-08-09 21:08:33
date last changed
2017-08-20 04:37:56
@article{6e77da5d-3582-46a6-83de-2991f9a6d3f4,
  abstract     = {BACKGROUND: <br/><br>
For unknown reasons girls are at an increased risk of coeliac disease compared to boys. However, the observed association might be confounded, since maternal coeliac disease is associated with both an increased risk of the disease in first-degree relatives as well as an increased ratio of girls to boys in offspring. <br/><br>
<br/><br>
AIMS: <br/><br>
We investigate the effect of sex on the risk of coeliac disease before the age of two years using sibling design. <br/><br>
<br/><br>
METHODS: <br/><br>
We identified all singleton children (n=792,401) born between 1987 and 1993 in Sweden using the Swedish Medical Birth Registry. Coeliac disease cases (2264) were identified using the Swedish National Inpatient Registry. We applied both conventional population-based Cox regression models and sibling designs modelling the association in sex discordant siblings. <br/><br>
<br/><br>
RESULTS: <br/><br>
We observed a conclusively increased risk of coeliac disease in girls compared to boys, using both sibling design (hazard ratio 1.67, 95% confidence interval 1.44-1.93) and conventional Cox regression analysis (hazard ratio 1.75, 95% confidence interval 1.61-1.91) that could not be explained by perinatal factors previously associated with the disease. <br/><br>
<br/><br>
CONCLUSIONS: <br/><br>
We confirm that female sex is causally associated with childhood coeliac disease, but the reasons remains unknown.},
  author       = {Wingren, Carl Johan and Agardh, Daniel and Merlo, Juan},
  issn         = {1590-8658},
  language     = {eng},
  number       = {11},
  pages        = {909--913},
  publisher    = {Elsevier},
  series       = {Digestive and Liver Disease},
  title        = {Sex differences in coeliac disease risk: A Swedish sibling design study.},
  url          = {http://dx.doi.org/10.1016/j.dld.2012.06.016},
  volume       = {44},
  year         = {2012},
}