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Carotid Velocities Determine Cerebral Blood Flow Deficits in Elderly Men with Carotid Stenosis

Siennicki-Lantz, Arkadiusz LU ; Wollmer, Per LU and Elmståhl, Sölve LU (2012) In International Journal of Vascular Medicine 2012.
Abstract
To examine if mild carotid stenosis correlates with silent vascular brain changes, we studied a prospective population-based cohort "Men born in 1914." Data from followups at ages 68 and 81, have been used. Carotid ultrasound was performed at age 81, and cerebral blood flow (CBF) was measured with SPECT at age 82. Out of 123 stroke-free patients, carotid stenosis <50% was observed in 94% in the right and 89% in the left internal carotid arteries (ICAs). In these subjects, Peak Systolic Velocities in ICA correlated negatively with CBF in a majority of several brain areas, especially in mesial temporal area. Results were limited to normotensive until their seventies, who developed late-onset hypertension with a subsequent blood pressure,... (More)
To examine if mild carotid stenosis correlates with silent vascular brain changes, we studied a prospective population-based cohort "Men born in 1914." Data from followups at ages 68 and 81, have been used. Carotid ultrasound was performed at age 81, and cerebral blood flow (CBF) was measured with SPECT at age 82. Out of 123 stroke-free patients, carotid stenosis <50% was observed in 94% in the right and 89% in the left internal carotid arteries (ICAs). In these subjects, Peak Systolic Velocities in ICA correlated negatively with CBF in a majority of several brain areas, especially in mesial temporal area. Results were limited to normotensive until their seventies, who developed late-onset hypertension with a subsequent blood pressure, pulse pressure, and ankle-brachial index growth. Elderly with asymptomatic carotid stenosis <50% and peak systolic velocities in ICA 0.7-1.3 m/s, should be offered an intensified pharmacotherapy to prevent stroke or silent cerebrovascular events. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
International Journal of Vascular Medicine
volume
2012
publisher
Hindawi Publishing Corporation
external identifiers
  • pmid:22778963
  • scopus:84866153005
ISSN
2090-2824
DOI
10.1155/2012/579531
language
English
LU publication?
yes
id
b3add78a-7938-4c10-8712-ed40f8fa7161 (old id 2967315)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22778963?dopt=Abstract
date added to LUP
2012-08-09 17:59:24
date last changed
2017-01-15 03:14:47
@article{b3add78a-7938-4c10-8712-ed40f8fa7161,
  abstract     = {To examine if mild carotid stenosis correlates with silent vascular brain changes, we studied a prospective population-based cohort "Men born in 1914." Data from followups at ages 68 and 81, have been used. Carotid ultrasound was performed at age 81, and cerebral blood flow (CBF) was measured with SPECT at age 82. Out of 123 stroke-free patients, carotid stenosis &lt;50% was observed in 94% in the right and 89% in the left internal carotid arteries (ICAs). In these subjects, Peak Systolic Velocities in ICA correlated negatively with CBF in a majority of several brain areas, especially in mesial temporal area. Results were limited to normotensive until their seventies, who developed late-onset hypertension with a subsequent blood pressure, pulse pressure, and ankle-brachial index growth. Elderly with asymptomatic carotid stenosis &lt;50% and peak systolic velocities in ICA 0.7-1.3 m/s, should be offered an intensified pharmacotherapy to prevent stroke or silent cerebrovascular events.},
  articleno    = {579531},
  author       = {Siennicki-Lantz, Arkadiusz and Wollmer, Per and Elmståhl, Sölve},
  issn         = {2090-2824},
  language     = {eng},
  publisher    = {Hindawi Publishing Corporation},
  series       = {International Journal of Vascular Medicine},
  title        = {Carotid Velocities Determine Cerebral Blood Flow Deficits in Elderly Men with Carotid Stenosis},
  url          = {http://dx.doi.org/10.1155/2012/579531},
  volume       = {2012},
  year         = {2012},
}