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Acute lung injury in acute pancreatitis - Awaiting the big leap.

Akbarshahi, Hamid LU ; Rosendahl, Ann LU ; Westergren-Thorsson, Gunilla LU and Andersson, Roland LU (2012) In Respiratory Medicine 106(9). p.1199-1210
Abstract
Acute lung injury is a severe complication to acute pancreatitis and a significant health problem associated with a considerable mortality. Underlying mechanisms are complex and poorly understood, although recent insights have identified several inflammatory profiles and cellular components involved to varying degrees during different phases of pancreatitis exacerbation and acute lung injury. This review aims to highlight the current understanding of the inflammatory and cellular components involved in and responsible for the associations of acute pancreatitis and acute lung injury, with the hope of thereby providing an increased understanding of the underlying mechanisms. In addition, novel experimental models of modulating the... (More)
Acute lung injury is a severe complication to acute pancreatitis and a significant health problem associated with a considerable mortality. Underlying mechanisms are complex and poorly understood, although recent insights have identified several inflammatory profiles and cellular components involved to varying degrees during different phases of pancreatitis exacerbation and acute lung injury. This review aims to highlight the current understanding of the inflammatory and cellular components involved in and responsible for the associations of acute pancreatitis and acute lung injury, with the hope of thereby providing an increased understanding of the underlying mechanisms. In addition, novel experimental models of modulating the pancreatitis-associated acute lung injury are presented, interventions that may be of potential future clinical value. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Respiratory Medicine
volume
106
issue
9
pages
1199 - 1210
publisher
Elsevier
external identifiers
  • wos:000308768300001
  • pmid:22749752
  • scopus:84864603666
ISSN
1532-3064
DOI
10.1016/j.rmed.2012.06.003
language
English
LU publication?
yes
id
4469ffc2-4063-4df2-ad54-361a27f0546e (old id 2967618)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22749752?dopt=Abstract
date added to LUP
2012-08-09 14:25:43
date last changed
2017-05-07 04:30:23
@article{4469ffc2-4063-4df2-ad54-361a27f0546e,
  abstract     = {Acute lung injury is a severe complication to acute pancreatitis and a significant health problem associated with a considerable mortality. Underlying mechanisms are complex and poorly understood, although recent insights have identified several inflammatory profiles and cellular components involved to varying degrees during different phases of pancreatitis exacerbation and acute lung injury. This review aims to highlight the current understanding of the inflammatory and cellular components involved in and responsible for the associations of acute pancreatitis and acute lung injury, with the hope of thereby providing an increased understanding of the underlying mechanisms. In addition, novel experimental models of modulating the pancreatitis-associated acute lung injury are presented, interventions that may be of potential future clinical value.},
  author       = {Akbarshahi, Hamid and Rosendahl, Ann and Westergren-Thorsson, Gunilla and Andersson, Roland},
  issn         = {1532-3064},
  language     = {eng},
  number       = {9},
  pages        = {1199--1210},
  publisher    = {Elsevier},
  series       = {Respiratory Medicine},
  title        = {Acute lung injury in acute pancreatitis - Awaiting the big leap.},
  url          = {http://dx.doi.org/10.1016/j.rmed.2012.06.003},
  volume       = {106},
  year         = {2012},
}