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Seroconversion to Islet Autoantibodies After Enterovirus Infection in Early Pregnancy.

Rešić Lindehammer, Sabina; Honkanen, Hanna; Nix, William Allan; Oikarinen, Maarit; Lynch, Kristian LU ; Jönsson, Ida LU ; Marsal, Karel LU ; Oberste, Steven; Hyöty, Heikki and Lernmark, Åke LU (2012) In Viral Immunology 25(4). p.254-261
Abstract
Gestational enterovirus (EV) infections have been associated with an increased risk for type 1 diabetes in the offspring. We therefore analyzed non-diabetic mothers for EV exposure in early pregnancy in relation to type 1 diabetes HLA-DQ risk genotypes and seroconversion to islet autoantibodies during pregnancy. Non-diabetic mothers who had islet autoantibodies (n=365) against glutamic acid decarboxylase (GADA), islet antigen-2 autoantibodies (IA-2A), or insulin autoantibodies (IAA), in early pregnancy and at delivery were compared to islet autoantibody-negative mothers (n=1457) matched for age and sampling date. Mothers were genotyped for HLA-DQ and analyzed for both EV-RNA and EV-IgM. EV-IgM, but not EV-RNA, was detected during early... (More)
Gestational enterovirus (EV) infections have been associated with an increased risk for type 1 diabetes in the offspring. We therefore analyzed non-diabetic mothers for EV exposure in early pregnancy in relation to type 1 diabetes HLA-DQ risk genotypes and seroconversion to islet autoantibodies during pregnancy. Non-diabetic mothers who had islet autoantibodies (n=365) against glutamic acid decarboxylase (GADA), islet antigen-2 autoantibodies (IA-2A), or insulin autoantibodies (IAA), in early pregnancy and at delivery were compared to islet autoantibody-negative mothers (n=1457) matched for age and sampling date. Mothers were genotyped for HLA-DQ and analyzed for both EV-RNA and EV-IgM. EV-IgM, but not EV-RNA, was detected during early pregnancy in 12% of islet autoantibody-positive mothers compared to 11% of the controls. In early pregnancy, mothers with HLA-DQ 2/2 or 2/X genotypes showed an increased risk for islet autoantibodies at delivery (OR 1.85; p=0.001). After adjusting for parity, maternal age, year of birth, and season of early pregnancy, early pregnancy EV-IgM combined with DQ2/2 or 2/X increased the risk for islet autoantibodies (OR 3.10; 95% CI 1; p=0.008). EV-IgM in early pregnancy increased the risk for islet autoantibodies at delivery in non-diabetic mothers with HLA-DQ 2/2 or 2/X type 1 diabetes risk genotypes. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Viral Immunology
volume
25
issue
4
pages
254 - 261
publisher
Mary Ann Liebert, Inc.
external identifiers
  • wos:000307729400004
  • pmid:22746839
  • scopus:84865010272
ISSN
0882-8245
DOI
10.1089/vim.2012.0022
language
English
LU publication?
yes
id
a35515ee-b787-4b0a-99f8-d0fea176e48f (old id 2967697)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22746839?dopt=Abstract
date added to LUP
2012-08-09 15:02:38
date last changed
2017-11-19 03:44:10
@article{a35515ee-b787-4b0a-99f8-d0fea176e48f,
  abstract     = {Gestational enterovirus (EV) infections have been associated with an increased risk for type 1 diabetes in the offspring. We therefore analyzed non-diabetic mothers for EV exposure in early pregnancy in relation to type 1 diabetes HLA-DQ risk genotypes and seroconversion to islet autoantibodies during pregnancy. Non-diabetic mothers who had islet autoantibodies (n=365) against glutamic acid decarboxylase (GADA), islet antigen-2 autoantibodies (IA-2A), or insulin autoantibodies (IAA), in early pregnancy and at delivery were compared to islet autoantibody-negative mothers (n=1457) matched for age and sampling date. Mothers were genotyped for HLA-DQ and analyzed for both EV-RNA and EV-IgM. EV-IgM, but not EV-RNA, was detected during early pregnancy in 12% of islet autoantibody-positive mothers compared to 11% of the controls. In early pregnancy, mothers with HLA-DQ 2/2 or 2/X genotypes showed an increased risk for islet autoantibodies at delivery (OR 1.85; p=0.001). After adjusting for parity, maternal age, year of birth, and season of early pregnancy, early pregnancy EV-IgM combined with DQ2/2 or 2/X increased the risk for islet autoantibodies (OR 3.10; 95% CI 1; p=0.008). EV-IgM in early pregnancy increased the risk for islet autoantibodies at delivery in non-diabetic mothers with HLA-DQ 2/2 or 2/X type 1 diabetes risk genotypes.},
  author       = {Rešić Lindehammer, Sabina and Honkanen, Hanna and Nix, William Allan and Oikarinen, Maarit and Lynch, Kristian and Jönsson, Ida and Marsal, Karel and Oberste, Steven and Hyöty, Heikki and Lernmark, Åke},
  issn         = {0882-8245},
  language     = {eng},
  number       = {4},
  pages        = {254--261},
  publisher    = {Mary Ann Liebert, Inc.},
  series       = {Viral Immunology},
  title        = {Seroconversion to Islet Autoantibodies After Enterovirus Infection in Early Pregnancy.},
  url          = {http://dx.doi.org/10.1089/vim.2012.0022},
  volume       = {25},
  year         = {2012},
}