Respiratory and allergic outcomes among 5-year-old children exposed to pesticides
Islam, Jessica Y. ; Hoppin, Jane ; Mora, Ana M. ; Soto-Martinez, Manuel E. ; Gamboa, Leonel Córdoba ; Castañeda, Jorge Ernesto Peñaloza ; Reich, Brian ; Lindh, Christian LU
and Van Wendel De Joode, Berna
(2023)
In Thorax
78(1).
p.41-49
- Abstract
Background: Little is known about the effects of pesticides on children's respiratory and allergic outcomes.We evaluated associations of prenatal and current pesticide exposures with respiratory and allergic outcomes in children from the Infants' Environmental Health Study in Costa Rica.Methods: Among 5-year-old children (n=303), we measured prenatal and current specific gravity-corrected urinary metabolite concentrations of insecticides (chlorpyrifos, pyrethroids), fungicides (mancozeb, pyrimethanil, thiabendazole) and 2,4-D.We collected information from caregivers on respiratory (ever doctor-diagnosed asthma and lower respiratory tract infections (LRTI), wheeze and cough during last 12 months) and allergic (nasal allergies, itchy... (More)
Background: Little is known about the effects of pesticides on children's respiratory and allergic outcomes.We evaluated associations of prenatal and current pesticide exposures with respiratory and allergic outcomes in children from the Infants' Environmental Health Study in Costa Rica.Methods: Among 5-year-old children (n=303), we measured prenatal and current specific gravity-corrected urinary metabolite concentrations of insecticides (chlorpyrifos, pyrethroids), fungicides (mancozeb, pyrimethanil, thiabendazole) and 2,4-D.We collected information from caregivers on respiratory (ever doctor-diagnosed asthma and lower respiratory tract infections (LRTI), wheeze and cough during last 12 months) and allergic (nasal allergies, itchy rash, ever eczema) outcomes.We fitted separate multivariable logistic regression models for high (≥75th percentile (P75)) vs low (<P75) metabolite concentrations with respiratory and allergic outcomes.We also ran models including metabolite concentrations as continuous exposure variables.Results: Children's respiratory outcomes were common (39% cough, 20% wheeze, 12% asthma, 5% LRTI).High current pyrethroid metabolite concentrations ( 'pyrethroids) were associated with wheeze (OR=2.37, 95% CI 1.28 to 4.34), itchy rash (OR=2.74, 95% CI 1.33 to 5.60), doctor-diagnosed asthma and LRTI.High current ethylene thiourea (ETU) (specific metabolite of mancozeb) was somewhat associated with LRTI (OR=2.09, 95% CI 0.68 to 6.02).We obtained similar results when modelling 'pyrethroids and ETU as continuous variables.We saw inconsistent or null associations for other pesticide exposures and health outcomes.Conclusions: Current pyrethroid exposure may affect children's respiratory and allergic health at 5 years of age.Current mancozeb exposure might contribute to LRTI.These findings are important as pyrethroids are broadly used in home environments and agriculture and mancozeb in agriculture.
(Less)
- author
- Islam, Jessica Y.
; Hoppin, Jane
; Mora, Ana M.
; Soto-Martinez, Manuel E.
; Gamboa, Leonel Córdoba
; Castañeda, Jorge Ernesto Peñaloza
; Reich, Brian
; Lindh, Christian
LU
and Van Wendel De Joode, Berna
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- asthma epidemiology, paediatric asthma, respiratory infection
- in
- Thorax
- volume
- 78
- issue
- 1
- pages
- 41 - 49
- publisher
- BMJ Publishing Group
- external identifiers
-
- pmid:35210357
- scopus:85142527489
- ISSN
- 0040-6376
- DOI
- 10.1136/thoraxjnl-2021-218068
- language
- English
- LU publication?
- yes
- id
- 29eee799-56ec-47b4-a37c-611a6de9282e
- date added to LUP
- 2023-01-26 11:49:50
- date last changed
- 2024-04-18 11:17:06
@article{29eee799-56ec-47b4-a37c-611a6de9282e,
abstract = {{<p>Background: Little is known about the effects of pesticides on children's respiratory and allergic outcomes.We evaluated associations of prenatal and current pesticide exposures with respiratory and allergic outcomes in children from the Infants' Environmental Health Study in Costa Rica.Methods: Among 5-year-old children (n=303), we measured prenatal and current specific gravity-corrected urinary metabolite concentrations of insecticides (chlorpyrifos, pyrethroids), fungicides (mancozeb, pyrimethanil, thiabendazole) and 2,4-D.We collected information from caregivers on respiratory (ever doctor-diagnosed asthma and lower respiratory tract infections (LRTI), wheeze and cough during last 12 months) and allergic (nasal allergies, itchy rash, ever eczema) outcomes.We fitted separate multivariable logistic regression models for high (≥75th percentile (P75)) vs low (<P75) metabolite concentrations with respiratory and allergic outcomes.We also ran models including metabolite concentrations as continuous exposure variables.Results: Children's respiratory outcomes were common (39% cough, 20% wheeze, 12% asthma, 5% LRTI).High current pyrethroid metabolite concentrations ( 'pyrethroids) were associated with wheeze (OR=2.37, 95% CI 1.28 to 4.34), itchy rash (OR=2.74, 95% CI 1.33 to 5.60), doctor-diagnosed asthma and LRTI.High current ethylene thiourea (ETU) (specific metabolite of mancozeb) was somewhat associated with LRTI (OR=2.09, 95% CI 0.68 to 6.02).We obtained similar results when modelling 'pyrethroids and ETU as continuous variables.We saw inconsistent or null associations for other pesticide exposures and health outcomes.Conclusions: Current pyrethroid exposure may affect children's respiratory and allergic health at 5 years of age.Current mancozeb exposure might contribute to LRTI.These findings are important as pyrethroids are broadly used in home environments and agriculture and mancozeb in agriculture.</p>}},
author = {{Islam, Jessica Y. and Hoppin, Jane and Mora, Ana M. and Soto-Martinez, Manuel E. and Gamboa, Leonel Córdoba and Castañeda, Jorge Ernesto Peñaloza and Reich, Brian and Lindh, Christian and Van Wendel De Joode, Berna}},
issn = {{0040-6376}},
keywords = {{asthma epidemiology; paediatric asthma; respiratory infection}},
language = {{eng}},
number = {{1}},
pages = {{41--49}},
publisher = {{BMJ Publishing Group}},
series = {{Thorax}},
title = {{Respiratory and allergic outcomes among 5-year-old children exposed to pesticides}},
url = {{http://dx.doi.org/10.1136/thoraxjnl-2021-218068}},
doi = {{10.1136/thoraxjnl-2021-218068}},
volume = {{78}},
year = {{2023}},
}